1 results about "Sensitivity drugs" patented technology

The application discloses a kind of butyrolactone compound in preparation treatment renal clear cell carcinoma drug purposes, characteristic is the compound structural formula as shown in I, the purposes of the compound in preparation anti renal clear cell carcinoma tumor drug and in preparation promote renal clear cell carcinoma sorafenib treatment sensitivity drug, its preparation method is by carrying out fermentation culture to marine fungus, obtains fermentation, then the fermentation is soaked with ethyl acetate and is extracted to obtain crude extract, again the crude extract is sequentially separated by normal phase medium pressure column chromatography, reversed phase medium pressure column chromatography and semi-preparative reversed phase high performance liquid chromatography separation and purification is obtained, advantage is that renal clear cell carcinoma can be significantly enhanced to sorafenib treatment sensitivity, can effectively inhibit tumor growth and delay the emergence of drug resistance.