4results about How to "Easy to clear" patented technology

This invention relates to a method for constructing a polycystic kidney disease (PCD) model and its applications. The method involves overexpressing the MYCN gene in a target animal to obtain a PCD model that leads to PCD-related phenotypes. The method includes the following steps: obtaining a first strain of mice with Rosa26 knock-in overexpressing the CAG-LSL-HA tag-MYCN-IRES-BFP-Wpre-polyA gene; obtaining a second strain of mice by inserting Cre-WPRE-polyA into the start codon of the Pax8 gene; and crossing the first and second strains of mice to obtain a MYCN-overexpressing PCD model. This invention employs various experimental methods for validation, including histopathological analysis, immunohistochemical staining, and Western blotting. The model provided by this invention overcomes the limitations of existing in vitro cell models, organoids, and existing animal models in terms of limited phenotypes. The established MYCN-overexpressing PCD animal model exhibits stable disease progression and a short disease cycle, which not only helps to elucidate the disease mechanism but also serves as an ideal platform for drug screening and efficacy evaluation.

The utility model discloses an inflow garbage filtering device for a sewage treatment plant, which relates to the technical field of sewage treatment and particularly comprises a box body, a guide rail is fixedly connected to one side of the box body, a fixing frame is slidably connected to one side of the guide rail, a first motor is fixedly connected to one side of the box body, and a second motor is fixedly connected to the other side of the box body. An output shaft of the first motor is fixedly connected with a threaded rod, a fixing block is arranged on the outer surface of the threaded rod, and one side of the fixing block is fixedly connected with one side of a fixing frame. According to the inlet water garbage filtering device for the sewage treatment plant, through cooperative arrangement of the fixing frame, the first motor, the threaded rod, the fixing block, an electric push rod, a connecting block, a second spring, an adjusting block, a push plate, a flow guide plate, a fixing cylinder, a first spring, a connecting rod and an extrusion plate, cleaned garbage can be extruded in the using process; therefore, the effect of reducing the water content in the garbage is achieved, and the purpose of conveniently clearing and transporting the garbage is achieved.

This utility model discloses a car wash pool that is easy to clean, belonging to the field of car wash pool cleaning technology. It includes a car wash pool with multiple equally spaced grooves at the bottom and a frame installed on the top. The frame is equipped with cleaning components for treating mud and sand in the grooves. A collection pool is installed on the outer wall of the car wash pool, and the collection pool and the car wash pool are connected by a rectangular hole. A lifting frame is installed inside the collection pool, and the lifting frame is equipped with a lifting and cleaning component. Therefore, by setting trapezoidal sand-pushing blocks adapted to the shape of the trapezoidal grooves, with each sand-pushing block corresponding to a groove, the sand-pushing blocks can closely fit the inner wall of the grooves during movement, thoroughly scraping away and pushing the mud and sand attached to the bottom and side walls of the grooves into the collection pool, effectively solving the problems of mud and sand accumulation and incomplete cleaning in traditional trenches.

The invention discloses an accounting bill processing device for financial accounting, and particularly relates to the field of bill smashing devices. Comprising a crushing box; the batch conveying assembly is used for conveying the bills into the crushing box in batches; the guide plate is arranged in the crushing box; the two first rotating shafts are rotationally connected to the inner wall of the crushing box; the first crushing cutter head and the second crushing cutter head are respectively arranged on the two first rotating shafts; the driving motor is coaxially connected with the first rotating shaft; the gear set is composed of two gears which are meshed with each other; and the collecting box is connected into the crushing box in a sliding manner. By the adoption of the technical scheme, the problem that an existing bill processing device cannot process thick bills is solved, and the continuity and reliability of bill processing can be guaranteed.