The invention discloses a preparation method of a 
drug-loaded 
wound dressing. The method mainly comprises the following steps: adding 
polyurethane hydrogel particles, 
thermoplastic polyurethane particles and a 
solvent into a reactor, heating and stirring to fully dissolve the 
polyurethane hydrogel particles and the 
thermoplastic polyurethane particles in the 
solvent, and cooling to obtain a polyurethane solution; adding 
Yunnan Baiyao powder, stirring evenly to obtain a 
solid-liquid mixture, and defoaming under reduced pressure; uniformly applying the 
solid-liquid mixture to release paper, andimmersing the release paper in deionized water; after the 
solid-liquid mixture is completely cured for formation of a film, placing the film in a 
dry box at 50 DEG C; after cooling, removing the release paper to obtain a 
Yunnan Baiyao-immobilizing film; soaking the 
Yunnan Baiyao-immobilizing film in 
Callicarpa macrophylla Vahl extract for 3 hours, and freeze-
drying under vacuum to obtain a double-
drug-loading film; according to the actual application requirements, 
cutting the double-
drug-loading film into an appropriate size, and pasting the 
cut double-drug-loading film onto medical non-wovengauze to obtain the product. The raw materials of the drug-loaded 
wound dressing are easy to obtain, the equipment is simple, and the product can stop bleeding, disperse 
blood stasis, relieve swellingand relieve pain, and has the effect of antisepsis and anti-
inflammation.