The invention belongs to a traditional Chinese medicine preparation, in particular relates to a Shenkang injection compound preparation for treating chronic renal failure. The Shenkang injection compound preparation for treating chronic renal failure is prepared from the following bulk pharmaceutical chemicals: 1500g of rheum officinale, 1500g of roots of the red-rooted salvia, 4500g of Astragalus mongholicus and 1500g of red flower. The preparation method comprises the following steps of: after the bulk pharmaceutical chemicals of the rheum officinale and the roots of red-rooted salvia are extracted in the ratio in the formula, carrying out primary ethanol precipitation, removing tan, carrying out secondary ethanol precipitation and water precipitation, carrying out third ethanol precipitation, and carrying out secondary water precipitation to remove pyrogen and sterilize; then, extracting the red flower and the Astragalus mongholicus in the ratio in the formula, carrying out primary ethanol precipitation and water precipitation, and carrying out secondary ethanol precipitation and water precipitation to remove pyrogen and sterilize; and finally, combining the two groups of liquid medicine, diluting, carrying out ultrafiltration and fine filtering, and sterilizing to obtain the Shenkang injection compound preparation. The Shenkang injection compound preparation has the advantages of precision in regulating the original ratio, high effectiveness, smaller side effect, high acting speed and high bioavailability. In addition, the product quality and the production efficiency are further improved, and energy consumption is reduced.