Production of 2,6-diamino-pyridine

A technology of diaminopyridine and pyridine, applied in 2 fields, can solve the problems of difficult control of reaction process, low reaction yield and many side reactions, and achieves the effects of moderate reaction temperature, high reaction yield and short reaction time

Inactive Publication Date: 2007-09-05
ZHEJIANG CHARIOTEER PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In summary, from the perspective of the reaction yield, the (3) process route seems to be the best, but the preparation process of its 3-hydroxyglutaronitrile needs to use highly toxic cyanide as a raw material, the price is high and the supply is few , so it is not suitable for industrial production; although the reaction yields of the other two process routes are similar, considering various factors such as raw material source, price and complexity of the process, the pyridine amination method is more competitive
However, the process still has many side reactions, low reaction yield, and difficult control of the reaction process.

Method used

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  • Production of 2,6-diamino-pyridine

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Embodiment 3

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Abstract

A 2.6-diaminopyridine is prepared through heating amino sodium, organic solvent and phase-transfer catalyst at 140-220 deg.C for 0.5-3 hr, dripping pyridine, Chichibabin reaction, cooling, adding water, hydrolysis reaction, cooling, crystallizing and filtering.

Description

(1) Technical field The invention relates to a method for preparing 2,6-diaminopyridine, in particular to a method for preparing 2,6-diaminopyridine based on Chichibabin reaction. (2) Background technology 2,6-Diaminopyridine is one of the intermediates of medicine, pesticide and dyestuff. According to the U.S. Patent US1680108 report, the phenazopyridine hydrochloride produced as a raw material with this intermediate is an important drug for the treatment of urinary system diseases; Lightfastness is significantly improved. There are three main processes for the synthesis of 2,6-diaminopyridine: (1) Ammonolysis of 2,6-dihalopyridine Fischer and Chur [J Prakt.Chem. (2) 84,439 (1911)] first reacted with 2-chloropyridine and liquid ammonia, synthesized 2-aminopyridine, on this basis, people such as Steinhauser [J.Prakt. Chem.(2) 93,387(1916)] by 2,6-dibromopyridine and liquefied ammonia react under high temperature and high pressure, obtain 2,6-diaminopyridine, Den.Herto...

Claims

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Application Information

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IPC IPC(8): C07D213/73
Inventor曾作祥陈旭辉蒲通王乃星杨益富范一陈恬薛为岚袁雄军
OwnerZHEJIANG CHARIOTEER PHARMA