36 results about "Diamidopyridine" patented technology

The invention relates to the technical field of marine antifouling materials, in particular to a modified polyurethane marine antifouling coating based on a metal pyridine structure and a preparation method. According to the modified polyurethane marine antifouling paint based on the metal pyridine structure, polyhydric alcohols and diisocyanate monomers with different molecular weights are subjected to condensation polymerization to obtain a polyurethane prepolymer; then reacting a diaminopyridine monomer or a dihydroxypyridine monomer with a metal ion compound to obtain a chain extender with a metal pyridine structure; finally, the marine antifouling paint is prepared through the reaction between the terminal amino or hydroxyl of the metal pyridine structure chain extender and the terminal isocyanate group of the polyurethane prepolymer, the metal pyridine structure is introduced into polyurethane, the mechanical performance of the marine antifouling paint is enhanced, the marine antifouling paint is endowed with the antibacterial effect through metal ion release, and the service life of the marine antifouling paint is prolonged. Adhesion and growth of marine fouling organisms can be effectively inhibited, and an efficient and durable solution is provided for development of a polyurethane marine antifouling coating.

The invention discloses a preparation method of a polyurea elastomer containing multiple hydrogen bonds and metal coordination bonds, aiming at the problem of poor repeated processability of a single dynamic bond and a cross-linked polyurea elastomer, the multiple hydrogen bonds are introduced through dihydrazide chain extension, and network toughness integration is realized through coordination of pyridine and metal ions, so that the toughness of the polyurea elastomer is improved. A polyurea elastomer containing multiple hydrogen bonds and metal coordination bonds is developed. The specific method comprises the following steps: firstly, preparing an isocyanate-terminated prepolymer A, secondly, quantitatively adding the isocyanate-terminated prepolymer A, 2, 6-diaminopyridine, dihydrazide, metal chloride and a catalyst into a solvent according to a certain sequence, stirring and reacting to obtain the double dynamic network polyurea elastomer, and finally forming a product by adopting a polymer secondary processing mode. The raw materials are cheap and easy to obtain, and the preparation process is simple and efficient and suitable for batch production.

The invention relates to the field of solid electrolyte preparation, and particularly discloses a solid electrolyte preparation method, a solid electrolyte and a battery, and the solid electrolyte preparation method comprises the following steps: step 1, synthesis of a pyridyl covalent organic framework (PCOF): dissolving 1, 3, 5-triformyl benzene and 2, 6-diaminopyridine pyridyl amine monomers in a mixed solvent of m-trimethylbenzene and 1, 4-dioxane, and stirring to obtain a solid electrolyte solution; the preparation method comprises the following steps: adding an acetic acid catalyst under the protection of argon, reacting at 100-130 DEG C for 48-96 hours, and then carrying out centrifugal separation, cleaning, neutralization, secondary cleaning and drying to obtain PCOF powder; by introducing the flexible diethylene glycol (DEG) group with relatively high polarity, the interface contact between the DEG-PMCOF and the lithium metal electrode is tighter, the interface impedance is effectively reduced, the overall performance of the battery is improved, meanwhile, the overall toughness of the material is remarkably enhanced through the flexible characteristic of the DEG, the problems of crack generation and layering in the cycle process of the battery are reduced, and the service life of the battery is prolonged. The mechanical property and the long-term stability of the material are improved.

The present disclosure relates generally to toll like receptor modulator compounds, such as diamino pyrido[3,2 D] pyrimidine compounds and pharmaceutical compositions which, among other things, modulate toll-like receptors (e.g. TLR-8), and methods of making and using them.

The invention provides a method for preparing 2, 6-diamino-3, 5-dinitropyridine, which comprises the following steps: (1) reacting 2, 6-diaminopyridine with an amino protection reagent to obtain an intermediate A; (2) in the presence of a dehydrating agent, carrying out double nitration reaction on the intermediate A and a nitration reagent to generate an intermediate B; (3) 2, 6-diamino-3, 5-dinitropyridine is obtained after the intermediate B is subjected to deprotection, and an amino protection reagent is selected from one or more of acetic anhydride, trifluoroacetic anhydride, di-tert-butyl dicarbonate, benzyl chloroformate and concentrated sulfuric acid; wherein the molar ratio of the amino protection reagent to the 2, 6-diaminopyridine is (2: 1)-(30: 1) by mole; and preferably, the ratio is 2: 1-12: 1.

The invention discloses a preparation method and application of a poly (2, 6-diaminopyridine) nanosheet with directional self-assembly of single micelle and controllable synthesis of mesopores. The preparation method comprises the following steps: respectively taking 2, 6-diaminopyridine, ammonium persulfate, a block copolymer polyethylene oxide-polystyrene copolymer and graphene oxide as raw materials, taking water, ethanol and tetrahydrofuran as self-assembly dispersing agents, and stirring at a constant speed at normal temperature to prepare the poly (2, 6-diaminopyridine) mesoporous nanosheet. The composite material has a nitrogen-doped carbon chain with a high specific surface area and regular mesopores capable of being used for diffusion, and can be used for storing zinc ions in a negative electrode of a zinc ion battery. The preparation method of the material is simple, low in preparation cost, green, environment-friendly and suitable for large-scale production.

The application belongs to the technical field of ship coating, and particularly relates to a self-repairing ship antifouling coating and a preparation method thereof. 2+ The preparation steps comprise the following steps: polyether amine and 1-pyrene butyric acid are reacted in an ethanol and water mixed solvent to obtain pyrene-based hyperbranched polyether amine; the pyrene-based hyperbranched polyether amine is reacted with p-phthalaldehyde modified by 2,6-diaminopyridine to form a dynamic polymer; a complex solution of ethylenediaminetetraacetic acid and Mg 2+ is added to the dynamic polymer to perform coordination complexation, and then a mixed solution is obtained; then, zinc oxide, BYK-333, Optifilm-400 and fumed silica are sequentially added to the mixed solution to obtain a multi-component mixed solution; after the multi-component mixed solution is dispersed, vacuum concentration is performed to obtain a self-repairing ship antifouling coating with a solid content of 45±5 wt%. The coating prepared by the method has good self-repairing and antifouling properties.

The present invention relates to a porous terephthalaldehyde-aminopyridine polymer and its preparation method and application. The preparation method comprises the following steps: 1) dispersing 2,6-diaminopyridine in a solution containing a surfactant and an alkali, and performing a polymerization reaction with terephthalaldehyde to obtain a terephthalaldehyde-aminopyridine condensation precursor, wherein the surfactant comprises F127 and sodium dodecylbenzenesulfonate; 2) calcining the terephthalaldehyde-aminopyridine condensation precursor to obtain a porous terephthalaldehyde-aminopyridine polymer. The porous terephthalaldehyde-aminopyridine polymer prepared using the surfactant is used as a catalyst for photocatalytic aquatic production of H2O2. Compared with the prior art, the polymer prepared by the present invention can regulate the band gap structure by adjusting the pore structure, thereby enabling efficient and clean production of H2O2 in pure water without sacrificial agents and under visible light in situ. It has the advantages of simple preparation method and simple equipment, and has good industrial application prospects.

This invention discloses a supported bifunctional catalyst for the synthesis of CO2-based polycarbonate polyols and its preparation method. First, N-methylimidazolium tert-butylsalicylaldehyde is reacted with 3,4-diaminopyridine to obtain a Schiff base ligand, which is then coordinated with cobalt to obtain a Schiff base metal cobalt complex. Finally, this complex is reacted with chloromethyl polystyrene resin to generate a supported bifunctional Schiff base metal catalyst. When this catalyst is used for the thermocatalytic polymerization of CO2-based polycarbonate polyols, the reaction requires no co-catalyst, the polymerization reaction is relatively mild, carbon dioxide utilization is high, and the generated carbonate fragments reach over 94%; simultaneously, there is no catalyst residue, and the polymerization product is essentially colorless.

The invention relates to the technical field of medicines, in particular to a 2, 4-diaminopyridine compound as well as a preparation method and application thereof. The compound is shown in the following formula, can achieve strong inhibition on ULK1 enzyme activity, has good inhibition activity on ULK1 and ULK2 kinase, and has good treatment activity on at least one kind of cancer.

The present invention discloses a continuous process for amination of aminopyridines. Particularly, the invention provides a two-step or multi-step process comprising a first continuous nitration step followed by a continuous hydrogenation step to introduce an amino group to an 2-aminopyridine in meta position. Such diaminopyridine compounds are valuable starting materials in the manufacture of active pharmaceutical ingredients.

The application discloses a synthesis method of porous silica colloidal spheres, and relates to the technical field of biological medicines. The method comprises the following steps: 2,6-diaminopyridine is dissolved in a mixed solvent and dissolved by stirring; sodium hydroxide aqueous solution and ethylenediamine are added into the mixed solution, and tetraethyl orthosilicate and glyoxal are sequentially added into the mixed solution; the solution is transferred into a centrifugal tube, supernatant is poured away, the solid at the bottom of the centrifugal tube is reserved, and the solid is dispersed again by using ethanol; the obtained solid is dried in an oven, etching is carried out by using hydrofluoric acid, and porous silica colloidal spheres are obtained after centrifugal drying. In the application, a brand-new synthesis idea is designed by copolymerization of 2,6-diaminopyridine, ethylenediamine, glyoxal and tetraethyl orthosilicate, and by coating of an alkaline polymer, controllable etching of silicon is realized, and uniform porous silica colloidal spheres and silica colloidal spheres with a loose porous eggshell structure and a compact solid yolk structure are obtained.

The present disclosure relates to an isobenzofuran-1(3H)-one derivative, which is a kinase inhibitor, and a use thereof and, more specifically, to an isobenzofuran-1(3H)-one derivative having HPK1 inhibitory activity and MLK3 inhibitory activity and a pharmaceutical composition containing same for preventing or treating cancer, virus infectious diseases, Parkinson's disease, non-alcoholic steatohepatitis, or tuberculosis. In addition, the compound can be advantageously used as a composition for prevention or treatment of cancer as it is administered in combination with an anticancer agent or a cell therapy product.

The invention provides a reactive heterocyclic aromatic polyamide polymer, an aramid fiber, a preparation method and application. The reactive heterocyclic aromatic polyamide polymer is mainly formed by carrying out copolycondensation on p-phenylenediamine, 2, 5-diaminopyridine, terephthaloyl chloride and acyl chloride A containing a halogenated group in a solvent; the preparation method of the polymer comprises the following steps: mixing and dissolving the cosolvent and the solvent; adding p-phenylenediamine and 2, 5-diaminopyridine, and cooling to-20 to 0 DEG C; and adding terephthaloyl chloride and acyl chloride A containing a halogenated group, and neutralizing a byproduct generated by the polymerization reaction by using an acid-binding agent to obtain a reactive heterocyclic aromatic polyamide polymer solution. And preparing the reactive heterocyclic polyamide polymer solution into the reactive heterocyclic aramid fiber through a dry-jet wet spinning process. A heterocyclic ring structure and a halogenated aromatic ring structure are introduced into a main chain of the prepared reactive heterocyclic aramid fiber, so that reaction conditions are provided for subsequent functional modification, and the application field is expanded.

The invention provides a preparation method of a self-repairing polyurethane material based on multiple hydrogen-bond interaction. The preparation method comprises the following steps: firstly, synthesizing acryloyl chloride and glycinamide hydrochloride to obtain acryloyl glycinamide with a bisamide structure; a novel T-shaped chain extender glycyl dihydroxy amine (OH-NAGA-OH) carrying multiple hydrogen bond groups on a side chain is synthesized through the reaction of acryloyl glycyl amide and diethanol amine. The preparation method comprises the following steps: taking polytetrahydrofuran glycol (PTMG) and polydimethylsiloxane (PDMS) as flexible chain segments, taking the flexible chain segments as soft segments of polyurethane, taking isophorone diisocyanate as a hard segment, taking glycyl dihydroxylamine (OH-NAGA-OH) and 2, 6-diaminopyridine (DAP) as chain extenders, and carrying out polymerization reaction according to a molar ratio of PTMG to PDMS to OH-NAGA-OH to DAP of 1: 1: 2: 2, so as to obtain the self-repairing polyurethane material with multiple hydrogen-bond interaction. The polymer has excellent mechanical and self-healing capabilities, and provides more possibilities for application in materials of protective coatings, wearable electronics, flexible electronics, high-end equipment and the like.

A substance, in particular a functionalized oligomer or polymer, wherein the substance contains oligomeric or polymeric chains to which perfluoroaromatic compounds are coupled or which contain perfluoroaromatic compounds, wherein several, in particular two, three, four or five fluorine atoms of the perfluoroaromatic compound are each nucleophilically substituted by a functional group, characterized in that a functional group is coupled to the perfluoroaromatic compound such that a fluorine atom is substituted by a sulfur atom, wherein the functional group comprises a linear and / or branched saturated or unsaturated C n -body, especially a C2, C3, C6, C8, C 10 -, C 12 -, C 14 -, C 16 - or a C 18 -body having at one end the sulfur atom which substitutes a fluorine atom of the perfluoroaromatic compound, wherein at the other end of the Cn - body a quinuclidinium group or another quaternary N-group, in particular an ammonium, imidazolium, benzimidazolium, piperidinium, piperazinium, guanidinium, pyridinium group, preferably with counterions, in particular with a bis(trifluoromethylsulfonyl)amide anion or a mineral acid anion, in particular a halide (F - , Cl - , Br - , I - ) or SO4 2- , HSO 4- , PO4 3- , HPO4 2- , H2PO 4- , SO3 2- , SO3H - , Phosphonate R-PO3H - , Carbonate CO3 2- , HCO 3- , or with an organic carboxylic acid anion, in particular CH3COO - , HCOO - , is coupled, and / or that a functional group SO3 is coupled to a countercation, in particular to a metal countercation or an ammonium countercation in the form NR4 +containing R = H, alkyl, aryl or another N-basic cation, in particular imidazolium, benzimidazolium, guanidinium, which is coupled to a sulfur atom substituting a fluorine atom, and / or containing a functional group C5NH 10 containing, wherein the nitrogen atom substitutes the fluorine atom of the perfluoroaromatic compound, wherein in particular a residue is coupled via the nitrogen atom, wherein the residue preferably is a halide (F - , Cl - , Br - , I - ) or SO4 2- , HSO 4- , PO4 3- , HPO4 2 , H2PO 4- , SO3 2- , SO3H - , Phosphonate R-PO3H - , Carbonate CO3 2- , HCO 3- or an organic carboxylic acid anion, in particular CH3COO - , HCOO - , is.

The invention discloses a preparation method of a water photovoltaic power generation material and a power generation device thereof, and the water photovoltaic power generation material is a TpPa-SO3H-COF material or a TpPa-Py-COF material prepared by replacing p-phenylenediamine with 2, 5-diaminobenzene sulfonic acid or 2, 5-diaminopyridine in the process of preparing a TpPa-COF material. The method comprises the following steps: preparing a TpPa-SO3H-COF material solution or a TpPa-Py-COF material solution, preparing an organic filter membrane plated with a silver electrode, constructing a power generation membrane through an interfacial polymerization reaction, and finally additionally installing a copper wire to obtain the water photovoltaic power generation device. Two materials for preparing the water photovoltaic power generation device are explored from covalent organic frameworks (COFs) materials, and the electric signal output of voltage and current of the water photovoltaic power generation device is effectively improved through interfacial polymerization reaction construction.

The invention is directed to a process to prepare an aluminium salphen complex by reacting (i) a diamine compound selected from the group of an optionally substituted benzene-1,2-diamine, an optionally substituted 2,3-diaminopyridine and an optionally substituted 3,4-diaminopyridine, (ii) an optionally substituted salicylaldehyde or an optionally substituted 2-hydroxy-1-naphthaldehyde and (iii) aluminium diacetate chloride in a liquid reaction mixture also comprising an alcohol and a base compound.

The present invention provides a first-agent hair dye composition that dyes light-colored hair a vivid primary red color, exhibiting high red color saturation and excellent colorfastness. [Solution] A first hair dyeing agent composition containing one or more selected from (A) 1-hydroxyethyl-4,5-diaminopyrazole, (B) 2,6-diaminopyridine, and (C) 5-(2-hydroxyethylamino)-2-methylphenol or m-aminophenol, wherein the mass ratio of component (C) to component (B) [(C) / (B)] is 0.10 to 0.80.

The present disclosure relates to an isobenzofuran-1(3H)-one derivative, which is a kinase inhibitor, and a use thereof and, more specifically, to an isobenzofuran-1(3H)-one derivative having HPK1 inhibitory activity and MLK3 inhibitory activity and a pharmaceutical composition containing same for preventing or treating cancer, virus infectious diseases, Parkinson's disease, non-alcoholic steatohepatitis, or tuberculosis. In addition, the compound can be advantageously used as a composition for prevention or treatment of cancer as it is administered in combination with an anticancer agent or a cell therapy product.

To provide a method for treating a sexual dysfunction.SOLUTION: The present disclosure relates to a method for treating female or male sexual dysfunction, the method comprising orally administering to a female or male subject an effective amount of 3,4-diaminopyridine or a pharmaceutically acceptable salt thereof. For example, a method for treating sexual dysfunction in a subject in need thereof is provided, the method comprising orally administering to the subject an effective amount of 3,4-diaminopyridine phosphate.SELECTED DRAWING: None

The invention discloses a high-temperature and high-acid stable heavy metal chelating agent as well as a preparation method and application thereof, and belongs to the field of industrial wastewater treatment. The preparation method comprises the following steps: condensing 2, 6-diaminopyridine and o-phenylenediamine which are used as raw materials to obtain 2, 6-bis (benzimidazole-2-yl) pyridine; nitration and reduction are carried out, and amino groups are introduced; carrying out amidation reaction on the amination intermediate and 2-mercaptobenzothiazole-5-carboxylic acid, and introducing a thiol group; and carrying out nucleophilic substitution reaction on the obtained intermediate and bromohexadecane, and grafting a hydrophobic long chain to finally prepare the target chelating agent. Molecules of the chelating agent integrate a rigid heterocyclic ring, a thiol ligand and a hydrophobic chain, so that the chelating agent not only can efficiently and selectively chelate heavy metal ions under the conditions of high temperature and strong acid, but also can spontaneously gather after chelating and quickly settle through gravity to realize efficient solid-liquid separation, and has a wide application prospect.

The invention belongs to the technical field of photocatalysis, and particularly relates to a squaric acid-pyridine diamine polymer and a preparation method and application thereof.The preparation method includes the steps that squaric acid and 2, 6-diaminopyridine are subjected to a solvothermal reaction to form a Schiff base polymer, and the squaric acid-pyridine diamine polymer is obtained. The spectral response range of the D-A polymer is widened, the separation efficiency of electrons and holes is improved, and H2O2 in-situ generation is enhanced. The squaric acid-pyridine diamine polymer prepared by the method disclosed by the invention is used as a catalyst, the light absorption range of the squaric acid-pyridine diamine polymer is widened to the infrared range, and H2O2 can be prepared by utilizing a visible light source and pure water without the existence of a sacrificial agent.

The invention relates to the field of medicinal chemistry, and particularly discloses a novel TLR8 agonist intermediate as well as a preparation method and application thereof, which are suitable for process development of 4, 6-diaminopyridino [3, 2-d] pyrimidine TLR8 agonists. According to the preparation method, tert-butyl is adopted to replace 2, 4-dimethoxybenzyl to serve as an amino protecting group, so that the crystallization property of the intermediate is remarkably improved, column chromatography is avoided, the cost is reduced, and the process stability is improved. The preparation method of the TLR8 agonist intermediate comprises the steps of reduction, acylating chlorination, coupling, amination and the like, has the advantages of being easy and convenient to operate, high in yield, environmentally friendly and the like, and is particularly suitable for industrial production.

The application provides a ruthenium-poly-2,6-diaminopyridine (Ru-PDAP) catalytic material and a preparation method and application thereof, and belongs to the technical field of water treatment. The Ru-PDAP catalytic material provided by the application comprises porous poly-2,6-diaminopyridine (PDAP) and ruthenium nanoparticles (Ru) loaded on the surface and internal pores of the PDAP. The Ru-PDAP catalytic material provided by the application has a good cavity structure, the PDAP serves as an electron donor to provide an activation site for a periodate, and the mutual conversion of various valence states (0, 2+, 3+, 4+, 6+, 8+) of the Ru can provide more electrons for the oxidation and degradation of organic matters by the periodate, and has a good catalytic effect on the degradation of antibiotics by the periodate / hydrogen peroxide.

The present application relates to a kind of electric and thermal response hydrogen bond binder, preparation method and application, belong to binder material technical field.The structure formula of the adhesive is the polymer of six-arm initiator, diaminopyridine monomer, thymine monomer, methyl imidazole type ionic liquid.This hydrogen bond binder has multiple hydrogen bond action group, can give binder strong cohesive force, with electrostatic interaction group simultaneously, can controllably release hydrogen bond to improve adhesion, by active controllable free radical polymerization (ATRP) preparation binder, can accurately control and balance the adhesion / cohesion energy of polymer.The binder has electric / thermal response performance, to realize the application in different science and technology fields.

The application belongs to the field of medicine synthesis, and particularly relates to a preparation method of a URAT1 inhibitor intermediate. The method takes 2,3-diaminopyridine (salt) and 1-bromo-4-bromomethylnaphthalene as raw materials, stirs, monitors by HPLC, filters, paddles, and dries to obtain the product. The application can synthesize the product by only one reaction N 3 -[(4-bromonaphthalen-1-yl)methyl]-2,3-diaminopyridine (salt) is low in cost, simple, efficient, has a product yield of 65%-98%, a purity of 86-98%, and is suitable for industrial large-scale production.

The invention discloses a high-recovery spandex fiber and a preparation method thereof, and belongs to the technical field of elastic fibers. The spandex fiber of the present invention uses polytetrahydrofuran and MDI to prepare a prepolymer solution, and the prepolymer solution is reacted with a chain extender mixed solution to form a polyurethane urea solution, and high-resilience spandex is obtained by dry spinning of the polyurethane urea solution; wherein the chain extender mixed solution contains diethanolamine, p-phenylenediamine, diethylenetriamine, and also contains 2,6-diaminopyridine and / or 2,5-bis(aminomethyl)furans. The present invention can improve the performance of the obtained spandex fiber, improve the elongation at break and the elastic recovery rate of the fiber, and can improve the hygroscopic properties of the obtained spandex fiber, so as to improve the comfort of the fabric obtained by using the spandex fiber.

The present invention discloses a 1H-imidazo[4,5-B]pyridyl nitrogen mustard derivative and its preparation method and application, belonging to the technical field of pharmaceutical intermediates and anti-tumor drugs. Its structural formula is shown in Formula I: wherein R1, R2 and R3 are selected from any one of hydrogen, halogen or methyl. The present invention uses substituted 2,3-diaminopyridine and 4-[bis(β-chloroethyl)amino]benzaldehyde as raw materials, and obtains the target molecule in one step through a condensation reaction. At present, the synthesis of 1H-imidazo[4,5-B]pyridine compounds requires multi-step reactions, and separation and purification are cumbersome, while the synthesis step of the present invention only requires one step, and the separation method is simple. In vitro anti-tumor experiments show that the synthesized target compounds all have obvious anti-tumor effects, show strong pharmacological activity in inhibiting tumor cell proliferation, and have extensive research and development value in the field of anti-tumor drugs.

The invention discloses an irreversible thermochromic polydiacetylene material and application of the irreversible thermochromic polydiacetylene material in thermal runaway monitoring, and the irreversible thermochromic polydiacetylene material is prepared by the following steps: a) carrying out amidation coupling on 10, 12-25 carbon diyne acyl chloride and diaminopyridine to obtain bis (10, 12-25 carbon diyne) amidopyridine; and b) taking di (10, 12-25 carbon diyne) amidopyridine as a monomer, and carrying out ultraviolet irradiation in-situ topological polymerization to obtain the polydiacetylene material. The polydiacetylene material disclosed by the invention has irreversible thermochromism performance, is blue at room temperature, and can generate irreversible red purple or orange red conversion after being heated to 60-90 DEG C, that is, the material can still keep red purple or orange red after being cooled to room temperature. The polydiacetylene material can be used in the fields of temperature indication, transient thermal runaway monitoring and the like.