149 results about "Diamidopyridine" patented technology

The invention discloses a high strength and high toughness self-repairing thermoplastic polyurethane urea elastomer and a preparation method thereof. The self-repairing thermoplastic polyurethane ureaelastomer is synthesized by double chain extension of prepolymers generated from diisocyanate and polyether diols separately in the presence of 2,6-diaminopyridine and cysteamine. A pyridine ligand unit is introduced onto a main chain, and coordination bonds are formed between molecular chains through the coordination effect of metal ions, thereby forming interchain reversible molecular healing;at the same time, the coordination bonds act as dynamic crosslinking points and achieve the effects of limiting molecular chain slip and improving mechanical properties; a disulfide bond is introducedinto a macromolecular main chain through double chain extension, and the self-healing ability is improved in an association manner through a reversible exchange reaction of the main chain. The elastomer has the self-repairing efficiency being more than 85%, the tensile strength being not less than 8 MPa and the toughness being not less than 40 MJ / m<3>. The elastomer is capable of both improving mechanical properties and self-repairing performance, can maintain the integrity and functionality of materials against complex deformation, and has extremely high application value in the field of flexible electronic equipment.

A silver nanocomposite, a formation method for forming the silver nanocomposite, and an application method utilizing the silver nanocomposite. The silver nanocomposite includes a silver nanoparticle conjugated to a glycosaminoglycan (GAG) or glucose. The formation method includes chemically reacting silver nitrate with a reducing agent to form a silver nanoparticle conjugated to the reducing agent of a GAG or glucose. The application method may include topically applying the silver nanocomposite to a wound or burn as an anti-microbial with respect to an antibiotic-resistant genotype in the wound or burn, wherein the silver nanocomposite topically applied includes the silver nanoparticle conjugated to the GAG of 2,6-diaminopyridinyl heparin (DAPHP) or hyaluronan (HA). The application method may include applying the silver nanocomposite as a coating to plastic, a catheter, or a surgical tool, wherein the silver nanocomposite applied as the coating includes the silver nanoparticle conjugated to the GAG of DAPHP.

The invention belongs to the technical field of carbon nanomaterials, and discloses a green fluorescent carbon quantum dot, and a preparation method and an application thereof. The method comprises the following steps: (1) dispersing 2,3-diaminopyridine in an organic solvent to obtain a precursor solution; (2) reacting the precursor solution in a reaction vessel to obtain a solution containing thegreen fluorescent carbon quantum dot; and (3) separating and purifying the solution containing the green fluorescent carbon quantum dot to obtain the green fluorescent carbon quantum dot. The 2,3-diaminopyridine used as a reaction raw material undergoes a solvothermal one-step reaction to prepare the carbon quantum dot, so the preparation method has the advantages of fast reaction speed, few byproducts and intermediate products, easy obtaining and extremely small use amount of the raw material, low cost and good repeatability, and allows the quantum yield to reach up to 21%.

The invention discloses a macromolecular intumescent flame retardant with phosphorus and nitrogen and a synthesis method thereof. The synthesis method comprises the following steps: using acetonitrile as solvent and 3,9-dichloro-2,4,8,10-tetraoxa-3,9-diphosphaspiro-3,9-dioxa[5.5]undecane and 2,6-diaminopyridine as raw materials to react under the action of catalyst, and purifying the product to obtain poly(3,9-dichloro-2,4,8,10-tetraoxa-3,9-diphosphaspiro-3,9-dioxa[5.5]undecane)-2,6-diaminopyridine. The method of the invention is simple and is easy to control; the synthetized macromolecular intumescent flame retardant with phosphorus and nitrogen has better compatibility with the matrix and higher char forming characteristic; by adopting the method, the problem of migration, precipitationor volatilization in the machinings of the flame retardant and the polymer matrix can be solved basically; and the flame retardant does not contain halogen, thus the flame retardant is environmentally friendly and has good application prospect.

The invention belongs to the technical field of photocatalyst materials, and discloses a molecule modified carbon nitride photocatalyst as well as a preparation method and application thereof. The preparation method comprises the following steps that S1, dicyanodiamine and 2,6-diaminopyridine are mixed and dissolved in water; heating, stirring, dissolving and drying are performed to obtain a precursor; S2, the precursor obtained in the S1 is calcined to obtain modified graphite-phase carbon nitride; S3, the graphite-phase carbon nitride obtained in the step S2 is ground into powder; calcination is performed again; modified carbon nitride with high specific surface area is obtained. High-temperature calcination is firstly performed to obtain carbon nitride; then, secondary calcination is performed; oxygen gas in air is used for peeling oxidation, so that carbon nitride is peeled and oxidized; molecule doped carbon nitride with high specific surface area and high catalytic activity is prepared; the specific surface area is large (259.7m<2> / g); the reaction sites are many; high light absorption is realized on sunlight; high photocatalytic degradation capability is realized on organiccontaminants; when the photocatalyst is used for photocatalytic degradation on an aniline containing solution, the complete degradation can be realized within 1h.

The invention relates to a composite method of high-energy insensitive explosive 2,6-diamino-3,5-dinitro pyridine-1-oxide. In the method, 2,6-diamino pyridine is nitrified in a mixed acid or super acid nitrifying system; mixture is poured into trash ice to separate out yellow sediment; solid obtained by filtering is boiled by distilled water, and yellowish-brown solid is obtained by filtering; in acetic acid, or trifluoroacetic acid or organic acid solution, the nitrogen oxidation reaction of the 2,6-diamino-3,5-dinitro pyridine is realized at the temperature of 75-250 DEG C in the presence of peroxy acid and catalyst; and luminous yellow solid is obtained by filtering after reaction ends. The invention has moderate reaction condition, does not need special devices, has abundant raw material resources, low cost, simple technology, safe and reliable production, simple product aftertreatment and small harm on environment and satisfies the basic requirements of industrial scale-up production; in addition, the invention has high total yield of target products, obviously lowers cost and has stronger market competitiveness.

Disclosed herein is the use of aminopyridines, such as 3-aminopyridine, 4-aminopyridine or 3,4-diaminopyridine, in the management and treatment of cerebral palsy patients of all ages.

The present invention discloses a 2, 3-dichloropyridine preparation method comprising the following steps: (1) 2,3-dimethylamide pyridine is dissolved in water, then a caustic soda aqueous solution and a sodium hypochlorite aqueous solution are successively added, after the addition is completed, the mixture is heated for full reaction, after the reaction is completed, the system is adjusted to be neutral or acidic by use of hydrochloric acid, and water is removed by distillation to obtain a 2,3-diaminopyridine crude product; (2) the 2,3-diaminopyridine crude product is dissolved in hydrochloric acid, a catalyst is added, then a sodium nitrite aqueous solution is added dropwise, after the addition is complete, the2,3-diaminopyridine crude product is completely reacted, and after the reaction is completed, a 2, 3-dichloropyridine crude product is obtained by distillation; and (3) the 2, 3-dichloropyridine crude product is added into an organic solvent for complete dissolving, then cooled for recrystallization, crystals are filtered off and dried to obtain a 2, 3-dichloropyridine finished product. The method avoids the problem of very low tendency for side effects of 2-site chlorination, the production process is simple, the reaction is smooth and steady, production cost is low, product yield is high, and product purity is high.

A silica precursor having a selective adsorptivity with respect to cobalt ions is disclosed. The silica precursor includes a cross-linked 2,6-diamino pyridine group obtained by using 2,6-diamino pyridine, phosgene and 3-aminopropyltriethoxysilane.

The invention discloses an additive for wear resistance of lubricating oil, which comprises the following components in part by weight: 15 to 35 parts of antiwear agent, 6 to 29 parts of detergent dispersant and 12 to 26 parts of antioxidant preservative, wherein the antiwear agent consists of boric acid tributylester, phosphonic acid dibutyl ester, copper isooctoxyborate and cupric cyclohexoxylborate; the detergent dispersant consists of polybutene amine, polyisobutene carbamic acid ester and 2-aminopyridine; and the antioxidant preservative is boronized butanimide. The additive has wide use range, can be used in paraffin, naphthene and intermediate base oil, and also can be used in synthetic and semi-synthetic base oil. The additive has the advantages of effectively improving the wear resistance of the lubricating oil, strengthening the bearing capacity of the lubricating oil, making the lubricating oil have long service life, and having small dosage in the lubricating oil and simple and convenient preparation process.

The invention discloses a 3,4-diaminopyridinium oxynitride chiral catalyst and application thereof in Steglich rearrangement, and belongs to the technical field of asymmetric synthesis in organic chemistry. The 3,4-diaminopyridine oxynitride chiral catalyst is obtained by using 3-bromo 4-nitropyridine nitroxene oxynitride and D or L-prolinamide as raw materials and conducting chlorination and amination. The catalyst is used for asymmetric Steglich rearrangement of O-acyl dihydropyrazolone to obtain the alpha-quaternary carbon chiral C-acyl dihydropyrazolone, and high yield and excellent enantioselectivity are achieved. The catalyst is novel in structure, simple in synthesis method and excellent in catalytic rearrangement effect.

The invention discloses a hydrogen-bonded rare-earth metal europium complex fluorescent material and a preparation method thereof. The hydrogen-bonded rare-earth metal europium complex is prepared from a proton transfer compound formed by a rare earth metal element europium and 2,6-diamido-pyridine and pyridine-2,6-dioctyl phthalate in a hydrogen bond coordination manner. The hydrogen-bonded rare-earth metal europium complex fluorescent material has the characteristics of narrow fluorescence emission peak, good monochromaticity, strong fluorescence intensity, good thermal stability and the like, and is an ideal red fluorescent material.

The invention discloses 3,5-diaminopyridine and a preparation method of 3,5-dimethoxycarboxylaminopyridine. The preparation method comprises the following steps: using 3,5-dimethylpyridine to perform oxidation reaction so as to obtain 3,5-pyridinedicarboxylic acid; using 3,5-pyridinedicarboxylic acid to perform acyl chlorination and obtain 3,5-pyridinedicarbonyl chloride; using 3,5-pyridinedicarbonyl chloride to perform ammoniation reaction to obtain 3,5-pyridinedimethylformamide; and performing Hofmann degradation on the 3,5-pyridinedimethylformamide to prepare 3,5-diaminopyridine or 3,5-dimethoxycarboxylaminopyridine. In the invention, 3,5-dimethylpyridine is used as raw material to design the synthetic route of the target compound, the reaction conditions of each step are mild, the product purity and yield are obviously increased, the yield is more than 70%; and the aftertreatment of each step of the provided synthetic route is simple, the method is green and environmentally friendly, the oxidation product is solid manganese dioxide, the oxidation product can be recycled through filtering, and the compound 2 can be used to perform the next step without being separated.

Compounds of formula (I) and isomers, salts, solvates, chemically protected forms, and prodrugs thereof one of X1, X2 and X3 is N, and the others are CH; RN1 and RN2 together with the nitrogen atom to which they are attached form a nitrogen-containing heterocyclic ring having from 4 to 8 ring atoms; RN3 and RN4 together with the nitrogen atom to which they are attached form a nitrogen-containing heterocyclic ring having from 4 to 8 ring atoms and their use in treating diseases ameliorated by the inhibition of mTOR.

The invention discloses an adsorbent for separating NO in smoke. The adsorbent is prepared from, by mass, 1 part of template molecule, 2-20 parts of functional monomer and 10-25 parts of crosslinking agent wherein the temperate molecule is one of formic acid, acetic acid and oxalic acid, the functional monomer is one or more of acrylic acid, methylacrylic acid, acrylamide and 2,6-pyridinediamine, and the crosslinking agent is one or more of ethylene glycol dimethacrylate, N,N'-methylenediacrylamide and divinyl benzene. The adsorbent is prepared with the molecular imprinting technique, and has the advantages of being large in adsorption capacity and high in selectivity when being used for adsorbing NO in smoke; in addition, the adsorbent is low in recycling energy consumption and suitable for separating NO in smoke through a fixed-bed variable-temperature adsorption / desorption NO separation device.

The invention discloses a polysiloxane supramolecular elastomer with high mechanical properties and a self-repairing function as well as a preparation method and application thereof. The preparation method comprises the following steps of: carrying out a reaction on bis (3-aminopropyl)-terminated polydimethylsiloxane, 1, 6-hexamethylene diisocyanate and 2, 6-diaminopyridine as raw materials to obtain a polysiloxane block copolymer containing a ligand; and dissolving the polysiloxane block copolymer containing the ligand, dropwise adding a metal salt solution to obtain a polysiloxane supramolecular elastomer, and carrying out hot press molding and cold press molding to obtain a target product. The method is simple and mild in condition; reversible metal coordination bonds / ion clusters formed by thepreparation method of the invention endow the polysiloxane supramolecular elastomer with the self-repairing function at a proper temperature while enhancing and toughening a polysiloxane supramolecular network. The prepared polysiloxane supramolecular elastomer has huge application value in a flexible substrate material of wearable equipment.

The invention discloses a preparation method of three-dynamic cross-linked self-repairing polyurethane and a product thereof. The method comprises the following steps: adding diisocyanate, oligomericdihydric alcohol and diaminopyridine into a reaction system, heating to 70-90 DEG C by taking tetrahydrofuran as a solvent, and reacting for 3-6 hours; dropwise adding sultone or carboxylic acid lactone into the reaction system, and reacting for 1-3 hours at the temperature of 70-90 DEG C; and adding a metal salt into the reaction system, reacting for 6-12 hours at room temperature, pouring into apolytetrafluoroethylene mold, drying for 1-3 days at room temperature, and carrying out vacuum drying for 1-3 days at 40 DEG C to obtain the three-dynamic cross-linked self-repairing polyurethane. According to the preparation method, diaminopyridine respectively reacts with isocyanate groups, sultone or carboxylic acid lactone and metal ions to simultaneously introduce three dynamic reversible bonds including hydrogen bonds, zwitterions and metal coordination bonds into polyurethane to prepare the three-dynamic cross-linking self-repairing polyurethane, the preparation method is simple and easy to implement, and the repair efficiency can reach 98% under the mild condition of room temperature / 12 h or 40 DEG C / 0.5 h.

The invention discloses a cyanide-free chemical gold plating solution applied to the advanced wafer packaging field and a gold plating process thereof. The cyanide-free chemical gold plating solution is prepared from the following components: cyanide-free gold salt with the content of Au ions being 6-10 g / L, 10-60 g / L of a complexing agent, 10-60 g / L of conductive salt, 30-60 g / L of a buffer agent, 5-10 g / L of an anti-aging agent, 15-80 mg / L of an interfacial agent, 1-5 mg / L of a wetting agent, 50-80 mg / L of a reaction accelerator, and 0.2-5 mg / L of a stabilizer, wherein the reaction accelerator is a compound of 2,6-diaminopyridine and 3-pyridine methanol, and the mass concentration ratio of the 2,6-diaminopyridine to the 3-pyridine methanol is 2:1. The solution not only ensures the stability of the plating solution, but also enables a plated part to be easily spread on the surface of an electrode so as to achieve the purpose of uniform plating, and therefore the effect of void-free and seamless filling of wafer packaging micropores is further achieved.

Novel 2,6-diaminopyridine derivatives of formula wherein R1 and R2 are as defined below, are disclosed. These compounds inhibit cyclin-dependent kinases. These compounds and their pharmaceutically acceptable salts and esters have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors. This invention is also directed to pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment or control of breast, lung, colon and prostate tumors. Also disclosed are intermediates useful in the preparation of these novel 2,6-diaminopyridine derivatives.

The invention relates to a preparation method of high-energy insensitive explosive 2,6-diamino-3,5-dinitro pyridine-1-oxide. The method takes 2,6-diamino pyridine as a raw material; acyl group RCO-protection amino, peroxy acid R1COOOH / catalyst or sodium perborate oxidizing reaction realizes 2,6-diamino pyridine acylation and nitrogen oxidation reaction; a mixed acid or super acid nitrifying system is adopted to introduce nitryl on 3,5 site of 2,6-diacyl amino pyridine nitric oxide. The invention increases reaction safety, prevents nitrocompound from decomposing in the oxidation process and causes oxidation and subsequent nitratlon reaction to be easily carried out; in addition, the invention greatly lowers ubiquitous potential safety hazard in explosive synthesis, avoids use and maintenance of special equipment and devices and simplifies process flows; the invention has moderate reaction condition, does not need special devices, has abundant raw material resources, low cost, simple technology, safe and reliable production, simple product aftertreatment and small harm on environment, satisfies the basis requirements of industrial scale-up production.

The invention belongs to the technical field of photocatalytic materials, and discloses a platinum metal loaded carbon nitride film, and a preparation method and an application thereof. The preparation method provided by the invention comprises the following steps: S1, placing a carbon nitride precursor into a crucible, and placing a carrier above the crucible; S2, calcining the crucible of the step S1 so as to obtain a graphite-phase carbon nitride film loaded on the carrier; and S3, impregnating the graphite-phase carbon nitride film obtained in the step S2 into a platinum-containing compound solution, and carrying out reducing so as to obtain a platinum metal loaded graphite-phase carbon nitride film with high water flux. According to the invention, through high-temperature evaporationcoating to the carbon nitride precursor, carbon nitride is uniformly coated onto the carrier, wherein cyanoguanidine and 2,6-diaminopyridine are preferably selected to form a precursor; and through animpregnation-reduction method, platinum metal particles are loaded onto the surface of a carbon nitride film to obtain the carbon nitride film with high water flux, stronger visible-light absorptioncapability and excellent photocatalytic degradation activity to aniline sewage, wherein the carbon nitride film can completely degrade aniline in one hour.

A liquid-phase process is provided for the manufacture from glutaronitriles and related compounds of 2,6-diaminopyridine and related compounds, which are used industrially as compounds and as components in the synthesis of a variety of useful materials. The synthesis proceeds by means of a dehydrogenative aromatization process.

The invention discloses a synthesis method of 2-amino-4-fluoropyridine. The synthesis method comprises the following synthesis steps: 1, taking diaminopyridine as the raw material, carrying out oxidation reaction to prepare 2-aminopyridine N-oxide a; 2, subjecting the compound a to nitration reaction with mixed acid to obtain 2-amino-4-nitropyridine N-oxide b; 3, carrying out acylation reaction onthe compound b and an acylation reagent to obtain 2-acetamino-4-nitropyridine N-oxide c; 4, carrying out reduction reaction on the compound c to obtain 2-acetamino-4-aminopyridine d; 5, carrying outdiazo-reaction on the compound d and HBF4 to obtain diazonium fluoroborate e; and 6, carrying out Balz-Schiemann reaction on the compound e to introduce fluorine atoms and conducting hydrolysis deacetylation to obtain 2-amino 4-fluoropyridine. The method provided by the invention solves the problems of long synthesis route, complicated operation, serious pollution, high cost, low yield and the like in existing synthesis methods.

A method for preparing 2,6-diamino-3,5-dinitropyridine relates to a preparation method of nitropyridine, and solves the problems of low product purity, low yield and difficulty in industrialized production in the method for preparing 2,6-diamino-3,5-dinitropyridine by adopting the prior art. The first method comprises the steps as follows: preparing the sulfate of 2,6-diaminopyridine; mixing with fuming sulfuric acid and fuming nitric acid; and quenching, stirring, vacuum-filtering and drying to obtain 2,6-diamino-3,5-dinitropyridine. The second method comprises the steps as follows: mixing 2,6-diaminopyridine with fuming sulfuric acid and fuming nitric acid; and ice-quenching, vacuum-filtering and drying to obtain 2,6-diamino-3,5-dinitropyridin. The third method comprises the steps as follows: preparing the sulfate of 2,6-diaminopyridine; adding fuming sulfuric acid; and stirring, quenching and filtering to obtain 2,6-diamino-3,5-dinitropyridin. The methods have the advantages of high purity and high yield, and is suitable for the industrial production.

The invention relates to a nitramine explosive 1,3,5-trinitro-2,3-dihydro-1H-imidazo [4,5-b] pyridine-2-ketone and a preparation method thereof. The method comprises the steps of achieving a reaction close loop of 2,3-diaminopyridine and urea at a high temperature, extracting the mixture by boiled ethanol after the reaction is finished, filtering to obtain dark brown solid; achieving nitrification reaction on 2,3-dihydro-1H-imidazo [4,5-b] pyridine-2-ketone in different nitrification systems; pouring the mixture into trash ice after the reaction is finished, filtering and washing a filter cake to become neutral, and drying to obtain light yellow solid. The compound containing energy synthetized by the method is novel in structure, mild in reaction condition, simple in technology, safe and reliable to produce, simple to carry out post-treatment on the product, small in damage to the environment, does not need a special device, and meets the basic requirements of industrial amplification production.

This invention relates to dyeing compositions for the dyeing of keratin fibres comprising at least one oxidation base of the 2,5-diaminopyridine type, the use of the compositions for the dyeing of keratin fibres and a dyeing processes employing the compositions. Another object of the invention is to provide novel 2,5-diaminopyridine compounds for dyeing oxidation bases.

The invention provides a 2,6-diaminopyridine modified chitosan. A preparation method of the 2,6-diaminopyridine modified chitosan comprises the following steps: (1) dissolving chitosan into acetic acid solution to obtain chitosan acetic acid solution; (2) enabling ligand, water and glutaraldehyde aqueous solution to react under microwave radiation to obtain a mixture; (3) in the mixture of step (2), adding the chitosan acetic acid solution obtained in step (1), reacting under the microwave radiation, naturally cooling, adding NaOH aqueous solution for dipping, and carrying out suction filtration, washing and vacuum drying to obtain the 2,6-diaminopyridine modified chitosan. The invention also provides application of the 2,6-diaminopyridine modified chitosan in adsorption of amaranth and application of the 2,6-diaminopyridine modified chitosan for analyzing and detecting the amaranth in beverage. The preparation method disclosed by the invention is simple and feasible, and the obtained 2,6-diaminopyridine modified chitosan has good selective adsorption performance to food synthetic pigments, and can be applied to the analysis and detection field of the amaranth in the beverage.

A process is provided for the synthesis of a diaminopyridine, such as 2, 6-diaminopyridine and related compounds, which are used industrially as compounds and as components in the synthesis of a variety of useful materials. The synthesis proceeds by means of a chlorine-ammonia displacement in the presence of a copper source.

The invention discloses a preparation method of a precious metal-loaded porous organic framework atomic-scale catalyst for catalytic degradation of VOCs at normal temperature. The preparation method comprises the following steps: (a) preparing a carrier: adding 2,6-diaminopyridine and 1,3,5-benzenetricarbonyl trichloride into a dichloromethane solution containing triethylamine, conducting uniformstirring, putting the formed solution into an oil bath pot, and conducting heating for reaction to obtain a porous organic framework containing a pyridine-amide functional group; (b) conducting dipping for loading a precious metal, specifically, completely dipping the pyridine-amide porous organic framework into a precious metal salt solution, carrying out ultrasonic treatment and standing, then adding a sodium borohydride solution to reduce the precious metal, and conducting washing and drying to obtain a precious metal-loaded pyridine-amide porous organic framework atomic-scale active site catalyst semi-finished product; and (c) conducting calcining, specifically calcining the semi-finished product in a muffle furnace to obtain a finished product. The catalyst is high in atom dispersityand can form atomic-scale active sites, so that the catalytic efficiency is greatly improved.

The invention relates to a preparation method of Delafloxacin and intermediates thereof. The method comprises the following steps: firstly, taking 3-chloro-2,4,5-fluorobenzoic acid (compound 1) as a raw material and reacting the raw material with thionyl chloride to obtain a compound 2; secondly, condensing the compound 2 with N,N-dimethylamino ethyl acrylate to obtain a compound 3; thirdly, substituting the compound 3 and 3,5-difluoro-2,6-diaminopyridine to obtain a compound 4; fourthly, cyclizing the compound 4 by using an acid binding agent to obtain a compound 5; fifthly, reacting the compound 5 with 3-hydroxyazetidine hydrochloride to generate a compound 6; sixthly, hydrolyzing the compound 6 to obtain a compound 7; seventhly, salifying the compound 7 with meglumin to obtain the Delafloxacin.