The invention belongs to the field of organic synthesis and particularly relates to a preparation method of 2-methyl-3-bromopyridine. The preparation method includes the following steps that 1, diethyl malonate reacts with alkali metal to generate salt, then a methylbenzene solution of 2-chlorine-3-nitropyridine is added dropwise to be conducted a condensation reaction, and the 2-methyl-3-nitropyridine is obtained through decarboxylation under an acidic condition; 2, under the catalysis of Pd/C, methanol serves as a solvent, a hydrogenation reduction and suction filtration are conducted on the 2-methyl-3-nitropyridine, filtered liquid is condensed, and 2-methyl-3-aminopyridine is obtained; 3, the 2-methyl-3-aminopyridine reacts with acid to generate salt, the cooling is conducted to enable the temperature to be in -10 DEG C-0 DEG C, bromine is added dropwise, after the addition, then a sodium nitrite solution is added dropwise, after addition, pH of the solution is adjusted to be alkaline, then extracting, drying and concentration are conducted, and the 2-methyl-3-bromopyridine is obtained. The preparation method of the 2-methyl-3-bromopyridine has the advantages that the reaction condition is moderate, the operation is easy, the post-processing is simple, enlarged production is easy, and the preparation method is very suitable for industrial production; the catalysis effect is good, and the reaction yield ratio is high; the price of the raw material is low, and the production cost is low.