The invention relates to a ceramic PTC thermistor capable of resisting high pulse overload, and a manufacturing method thereof, wherein the raw materials comprise: 0.811-0.825 mol BaCO3, 0.175-0.189 mol CaCO3, 1.018-1.022 mol TiO2, 0.0026-0.0035 mol Y2O3, 0.00078-0.00096 mol Mn(NO3)2, 0.010-0.018 mol SiO2, 0.005-0.01 mol Al2O3, and 0.003-0.006 mol Si3N4, and ball-milling, pre-firing synthesis, secondary ball-milling mixing, spray granulation, pressing molding, sintering, silver electrode feeding, conducting wire welding and encapsulation are performed to prepare the product. According to the present invention, the product is particularly used as the load protection PTC thermistor of the starting circuits of high-power electric equipment such as electric automobile power-on pre-charging equipment and the like, wherein the resistance value is 1300-3000 omega, the high-voltage resistance is DC750V, the number of the times of power-on pulse resistance is not less than 5 each time, and thethermistor can be normally reused ten thousand times after being powered on for 1000 h.