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Determination of risk factors for cataract by aldose reductase genotype

A reductase and cataract technology, applied in the field of determining the risk rate of cataract through aldose reductase genotype, can solve the problem of low affinity

Inactive Publication Date: 2007-09-05
THE CHINESE UNIVERSITY OF HONG KONG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Fortunately, aldose reductase has a low affinity for glucose and little sorbitol is produced under euglycemic conditions

Method used

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  • Determination of risk factors for cataract by aldose reductase genotype
  • Determination of risk factors for cataract by aldose reductase genotype
  • Determination of risk factors for cataract by aldose reductase genotype

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Embodiment

[0049] Object and Diagnosis

[0050] The Diabetes Center of Prince of Wales Hospital in Hong Kong consecutively recruited 567 patients and diagnosed them according to World Health Organization standards (World Health Organization Technical Report Series (1985) 727). To increase the homogeneity of type 2 diabetes, those with diabetes diagnosed before age 35 and those with diabetes diagnosed for 3 years or less at the time of sample collection and who had been on insulin therapy were excluded. The presence of cataracts is indicated by direct ophthalmoscopy after pupil dilation, combined with best visual acuity sensitivity on Snellen's chart ≤ 20 / 70 in the same eye. Fundoscopy is performed by an ophthalmologist or a trained diabetes specialist.

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Abstract

This invention relates to methods for determining the risk of developing cataract in mammals, and, more specifically, in mammals, including humans, with non-insulin dependent diabetes. The methods are performed by determining the presence or absence of genetic markers in genomic DNA. The presence of a Z-2 allele, a microsatellite marker of the aldose reductase, is indicative of an increased risk for developing cataract. The presence of Z-4, a microsatellite allele of the aldose reductase gene, indicates a decreased risk for developing cataract. The methods comprise nucleic acid probes that hybridize to a nucleic acid encoding the microsatellite region of the mammalian aldose reductase gene. The probes may also be immobilized on a solid support to form a microarray. In addition, this invention is directed to methods for treating a mammal with a genetic predisposition for developing cataract; following a screening method that detects a Z-2 microsatellite marker of an aldose reductase gene the mammal is treated with an inhibitor of aldose reductase.

Description

[0001] This application is a divisional application of the international application PCT / CN02 / 00214, which entered the Chinese national phase on August 29, 2003, the application number is 02805722.8, and the title of the invention is "Determination of Cataract Risk Rate by Aldose Reductase Genotype". technical field [0002] The present invention relates to methods and compositions for determining the risk of developing cataracts in mammals, further including patients suffering from non-insulin dependent diabetes mellitus. The present invention is exemplified by the association of discrete microsatellite markers in the promoter region of mammalian aldose reductase genes with genetic predisposition to cataract development, especially in individuals with non-insulin dependent diabetes mellitus, including those with type II diabetes mellitus among the Chinese. The method includes detecting the microsatellite markers Z-2 and Z-4, which comprise alleles of the mammalian aldose redu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68C12Q1/26G01N33/50A61P27/12C12Q1/6883
CPCC12Q2600/156C12Q1/6883A61P27/12
Inventor 郭志良伍楚贤李少钦郭克伦陈重娥
Owner THE CHINESE UNIVERSITY OF HONG KONG
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