Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A detection method and technology for asthma tablets, which are applied in the field of detection of asthma tablets, can solve problems such as too simple quality control indicators, inability to control product quality, and influence on product efficacy, so as to control product quality, guide production well, and ensure reproducibility. Effect
Active Publication Date: 2010-06-09
贵州省科晖制药有限公司
View PDF0 Cites 0 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
Morphine in poppy shell is one of the active ingredients in the prescription, but it is also highly addictive. Codeine phosphate in poppy shell and ephedrine hydrochloride in ephedra are also active ingredients in the prescription. These three indicators The amount of content directly affects the curative effect of the product
Platycodon grandiflorum and licorice as raw materials, if not identified, will affect the quality of the product
However, the original standard for Asthma Tablets only provided qualitative identification methods for poppy shell and ephedra, without any content determination and identification indicators for bellflower and licorice. The quality control indicators were too simple to effectively control the quality of the product.
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
experiment example
[0020] Experimental example: content determination of morphine, codeine phosphate, and ephedrine hydrochloride
[0021] (1) Selection of mobile phase:
[0022] Mobile phase 1: 0.05mol / l potassium dihydrogen phosphate-methanol-acetonitrile-triethylamine (80:10:10:0.3);
[0023] Mobile phase 2: 0.05mol / l potassium dihydrogen phosphate-methanol-acetonitrile-triethylamine (75:7:18:0.4);
[0024] Mobile phase 3: 0.05mol / l potassium dihydrogen phosphate-methanol-acetonitrile-triethylamine (78:7:15:0.2);
[0025] Mobile phase 4: water-acetonitrile-phosphoric acid (90:10:0.1);
[0026] Mobile phase 5: 0.01mol / l potassium dihydrogen phosphate-acetonitrile-phosphoric acid (90:10:0.1);
[0027] Mobile phase 6: 0.01mol / l potassium dihydrogen phosphate-acetonitrile-phosphoric acid-triethylamine (90:5:0.2:0.2);
[0028] Mobile phase 7: 0.01mol / l potassium dihydrogen phosphate-acetonitrile-triethylamine-phosphoric acid (95:5:0.4:0.2)
[0029] Through the analysis of the above comparativ...
Embodiment
[0068] Asthma tablet detection methods include:
[0069] 1. Identification of Campanulaceae:
[0070] Weigh 0.5g of the fine powder of this product, put it in a stoppered test tube, add 2ml of 10% hydrochloric acid solution, bathe in water for 1h, take it out, centrifuge at 3500r / min for 10min, pour out the supernatant, adjust the pH to 9-10 with ammonia water, add 1ml of chloroform, Fully shake, 3000r / min centrifugal 10min, take chloroform layer as need testing solution; Another take 0.2g of bellflower contrast medicinal material, make contrast medicinal material solution with the same method; For the test, take 5 μl of each of the above two solutions, spot them on the same silica gel G thin-layer plate, use ethyl acetate: butanone: formic acid: water = 10:0.5:0.5:0.5 as the developer, develop, take out, and dry in the air , viewed under UV light (365nm). In the chromatogram of the test product, at the position corresponding to the chromatogram of the control medicinal mate...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
The present invention discloses a quality control method of asthma tablets, which includes the flowing steps: (1) chromatography conditions and system suitability experiment; (2) preparation of control solution; (3) preparation of test solution is as following: taking the product, removing the coating, porphyrizing, taking about 1g, placing into a 50ml volumetric flask, adding 1ml of ammonia testsolution and 25ml of chloroform precisely, weighing the weight, carrying out the ultrasonic treatment with the power of 260w and the frequency of 40KHz for 30 minutes, cooling, weighing the weight, using the chloroform to supplement the loss weight, shaking evenly, filtering, sucking 5ml of filtrate precisely, adding 2ml of 2 percent hydrochloric ethanol anhydrous, shaking evenly, drying up by evaporation in a water bath, adding 10ml of 0.1percent hydrochloric acid in the residual slag, full dissolving by ultrasound, filtering, and taking the subsequent filtrate; (4) weigh and suck the controlsolution and the test solution precisely and respectively to inject to an HPLC instrument for determination. The method adopts the HPLC to carry out the content determination of morphine, codeine phosphate and ephedrine hydrochloride in the prescription under a same system, which can not only ensure the efficacy of the products, but can also enable the quality of the products to be stable.
Description
technical field [0001] The invention belongs to the field of quality control of traditional Chinese medicine preparations, in particular to a detection method for asthma tablets. Background technique [0002] Asthma tablets are composed of poppy shell, bellflower, ephedra, and licorice four herbs, which have the effect of relieving cough and relieving asthma, and are used for cough and asthma. Poppy shell and ephedra are the main medicines in the prescription, mainly used to treat cough and asthma. Morphine in poppy shell is one of the active ingredients in the prescription, but it is also highly addictive. Codeine phosphate in poppy shell and ephedrine hydrochloride in ephedra are also active ingredients in the prescription. These three indicators The amount of the content directly affects the curative effect of the product. Platycodon grandiflorum and licorice as raw materials, if not identified, will affect the quality of the product. However, the original standard for...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more 
Login to view more