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Total chromocor extract of blumea riparia as well as pharmaceutical composition and preparing method thereof

A technology of total flavonoids and extracts, which is applied in the field of pharmaceutical compositions containing the effective parts of Aiinaxiang Diangui, can solve unrelated problems, and achieve the effects of small doses, broad application prospects, and stable quality

Inactive Publication Date: 2008-05-21
广西万寿堂药业有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above patents also do not involve the material basis of the hemostatic effect of Diangui Ainaxiang

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Example 1 Preparation of Total Flavonoids Extract from Diangui Ainaxiang

[0011] Take 30kg of Diangui Ainaxiang, chop, soak in water for 3 hours, extract twice, add water 10 and 8 times respectively, and extract for 1.5 hours and 1 hour respectively, filter, concentrate the filtrate, and the relative density of the concentrate is 1.10 (measured at 60°C), put on HPD100 macroporous adsorption resin column, the loading amount is medicinal material weight: macroporous resin weight=1.5:1, eluted with water, then eluted with 30% ethanol, and finally eluted with 60% ethanol , collect 60% ethanol eluate, concentrate after recovering ethanol, and dry to obtain 0.65 kg of total flavonoids extract of Ainaxiang osmanthus Dianensis; with rutin as reference substance, spectrophotometric determination shows that the total flavonoids content in the extract is 60% (Assay method refers to Chinese Pharmacopoeia 2005 edition one P246: Determination of total flavonoid content of Sophora ja...

Embodiment 2

[0012] Example 2 The preparation of the total flavonoids extract of Ai Naxiang from Yunnan

[0013] Take 30kg of Diangui Ainaxiang, chop, soak in water for 3 hours, extract twice, add water 10 and 8 times respectively, and extract for 1.5 hours and 1 hour respectively, filter, concentrate the filtrate, and the relative density of the concentrate is 1.13 (measured at 60°C), put on an AB8 macroporous adsorption resin column, the loading amount is the weight of medicinal material: weight of macroporous resin = 1:1, eluted with water, then eluted with 40% ethanol, and finally eluted with 70% ethanol , collect 70% ethanol eluent, concentrate after reclaiming ethanol, dry, and obtain 0.80kg of total flavonoids extract of Ai Naxiang Diangui; with rutin as reference substance, spectrophotometric determination, the total flavonoids content in the extract is 57% (Assay method refers to Chinese Pharmacopoeia 2005 edition one P246: Determination of total flavonoid content of Sophora japon...

Embodiment 3

[0014] Example 3 Efficacy Test of Total Flavonoids Extract from Diangui Ainaxiang

[0015] [sample]

[0016] The test product is an aqueous solution containing 100 mg of total flavonoids extract of Aiinaxiang yunnanensis per ml, which is equivalent to 4 g of the original medicinal material per ml. When used, it is diluted or concentrated, so that the administration volume of animals in each dosage group is equal. The doses in this test are expressed in g / kg of the original medicinal material.

[0017] [Experimental animals]

[0018] White mice: Kunming species, ♀♂ combined use, common grade, provided by the animal department of Guangxi Drug Control Institute, fed with pellet feed.

[0019] Guinea pig: ♀ sex, body weight 370-420g, common grade, purchased in the market. Adapt to the laboratory conditions for 1 week before testing.

[0020] Rabbit: Japanese big-eared white rabbit, weighing 1.8-3.0kg, for both ♀♂ and general grade, provided by the animal room of Guangxi Insti...

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PUM

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Abstract

The invention relates to an affective part of a vegetative medicine of Diangui blumea balsamifera and an extracting method thereof as well as a medicine composite containing the effective part of the Diangui blumea balsamifera. The method comprises the steps of: adopting big-pore resin to absorb, conducting ethanol grade washing and separation to obtain the total flavone extractive. The total flavone extractive of the Diangui blumea balsamifera is taken as the effective part to be solely used or used in the medicine composite for curing hemorrhage in gynae. The patient can conveniently take the medicine in small dosage reducing the per time dosage from 1g to 0.2g, moreover, the side effects are small and the curative effect is more distinct in addition that the quality is more stable. The invention is suitable for industrial production and has wide application prospect. The extraction rate of the total flavone extractive of the Diangui blumea balsamifera is 2 to 3 percent, and the content of the total flavone in the extractive is 50 to 60 percent. The products or the extractive of the invention can be made into troche, grain, oral liquid, pill, soft or hard capsule and other oral formulations by proper methods.

Description

technical field [0001] The present invention relates to the effective part of the herbal medicine Ainaxiang yunnanensis and its extraction method, and a pharmaceutical composition containing the effective part of Ainaxiang yunnanensis. Background technique [0002] Diangui Ainaxiang is the dried whole herb of Blumea riparia (BL.) DC in Compositae. It is a common medicinal material in Guangxi. Guangxi folks are used to treat women's menorrhagia, prolonged menstruation and postpartum lochia. It has a long history of use and has a definite curative effect. Currently, there are Diangui Ainaxiang Granules (formerly known as "Fuxuekang" Granules), which are made of Diangui Ainaxiang as the main ingredient, and are listed in the "National Compilation of Chinese Patent Medicine Standards Surgical Gynecology Subvolume". On page 590 of the first volume, the main functions are: promoting blood circulation and removing blood stasis, stopping bleeding and regulating menstruation. It is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61P7/04A61P15/00
Inventor 许振朝韦宏官谭文明肖伟覃唯法廖慧彬
Owner 广西万寿堂药业有限公司
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