Production method of stilbene glycoside extract

A technology of stilbene glycosides and ethanol, which is applied in the direction of medical preparations containing active ingredients, sugar derivatives, drug combinations, etc., can solve the problems of low yield, high cost, and long time, and achieve high yield and low cost. Low and time-consuming effects

Active Publication Date: 2008-06-11
XUANWU HOSPITAL OF CAPITAL UNIV OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The existing preparation method technology of stilbene glycoside extract adopts water extraction or ethanol extraction, concentration, and s...

Method used

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  • Production method of stilbene glycoside extract
  • Production method of stilbene glycoside extract
  • Production method of stilbene glycoside extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Take 20g of Radix Polygoni Multiflori, add 6 times the weight of 95% ethanol, heat and reflux to extract once, filter the extract, recover the ethanol from the filtrate and concentrate until it has no alcohol smell, add water, stir well, let stand for 4-12 hours, filter, and the filtrate Add ethyl acetate to extract twice, combine the extracts, recover ethyl acetate from the extracts and concentrate to a thick paste, dry under reduced pressure, and pulverize into fine powder to obtain 7.1 g of stilbene glycosides. After determination, the content of stilbene glycosides is greater than 55%, extraction rate 3.55%.

Embodiment 2

[0047] Take 20g of Radix Polygoni Multiflori, add 12 times the weight of 40% ethanol, heat and reflux to extract 5 times, each time for 1 hour, combine the extracts, filter, recover the ethanol from the filtrate and concentrate until it has no alcohol smell, add water, stir well, let stand for 4- After 12 hours, filter, add ethyl acetate to the filtrate and extract 4 times, combine the extracts, recover ethyl acetate from the extracts and concentrate to a thick paste, dry, and be ground into fine powder to obtain 7.2 g of stilbene glycosides. The content of styrene glycosides is greater than 55%, and the extraction rate is 3.6%.

Embodiment 3

[0049] Take 20g of Radix Polygoni Multiflori, add 8 times the weight and volume of 60% ethanol, heat and reflux to extract 3 times, 2 hours each time, combine the extracts, filter, recover the ethanol from the filtrate and concentrate until it has no alcohol smell, add water, stir well, and let it stand for 6 hours , filtered, the filtrate was extracted twice with ethyl acetate, the extracts were combined, the ethyl acetate was recovered from the extract and concentrated to a thick paste, dried under reduced pressure (60-90°C), and crushed into fine powder to obtain stilbene glycoside 7.25 g, after determination, the content of stilbene glycosides is greater than 55%, and the extraction rate is 3.62%.

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Abstract

The invention discloses a preparation method of stilbene glucoside, which comprises (1), adding polygonum multiflorum thumb with alcohol, heating and refluxing, filtering extract, recovering alcohol in the extract, concentrating until no alcohol smell left, obtaining concentrated solution or extract, (2), adding water into the concentrated solution or extract, mixing uniformly, standing, filtering and extracting the filtrate via acetic ester, (3), recovering acetic ester of extract liquid, concentrating to condensed ointment, drying and breaking to obtain stilbene glucoside. The inventive extract has stilbene glucoside content higher than 55%, with high yield, high product quality and simple process or the like.

Description

technical field [0001] The invention relates to a method for extracting active ingredients from plants, in particular to a method for extracting stilbene glycosides from Radix Polygoni Multiflori, belonging to the field of traditional Chinese medicine. Background technique [0002] Polygonum multiflorum is the dry tuber root of Polygonum multiflorum Thunb, a Polygonum multiflorum Thunb. According to its different processing methods, it can be divided into raw Shouwu and made Shouwu. Raw Shouwu is bitter, astringent, and flat in nature. It has the effects of moistening the intestines, detoxifying, and cutting off malaria. It is used for intestinal dryness, constipation, carbuncle, scrofula and other diseases. Shouwu is bitter, sweet, astringent, and warm in nature. It has the effects of nourishing liver and kidney, nourishing essence and blood, strengthening muscles and bones, and blackening hair. It is mainly used for deficiency of liver and kidney essence and blood, dizzin...

Claims

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Application Information

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IPC IPC(8): C07H15/18A61K31/7034A61K36/704A61P25/28A61K125/00
Inventor 李林王文魏海峰艾厚喜
Owner XUANWU HOSPITAL OF CAPITAL UNIV OF MEDICAL SCI
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