Human myocardium protecting gene and uses thereof

A myocardial protection and genetic technology, applied in gene therapy, genetic engineering, plant genetic improvement, etc.
CN101200721BInactive Publication Date: 2011-06-08ZHONGSHAN HOSPITAL FUDAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHONGSHAN HOSPITAL FUDAN UNIV
Publication Date
2011-06-08
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention belongs to the biotechnological field and relates to a human myocardial protection gene heat shock transcription factor (HSF1) and a sieving method and a purpose thereof. The present invention adopts the method of ''death trap'' that the gene which resists myocardial cell death is sieved from human cardiac gene, and the human myocardial protection gene heat shock transcription factor 1 is cloned from the obtained gene. The result of transfection cell and animal experiment shows that the obtained human myocardial protection gene has the function of resisting cell death and also has the function of resisting ischemia, protecting myocardial cell and preventing and remedying the heart failure occurrence and development inside the heart of a living organism. The present invention can prepare for the medicine for remedying the ischemic heart disease and preventing the cardiac insufficiency and provides a novel target gene for the further function research and the gene engineering medicine development, which has important meaning for the early prevention and treatment of the heart failure and the research and the development of the related medicines and measures.
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Description

technical field

[0001] The invention belongs to the field of biological technology and relates to a human cardioprotective gene, in particular to a human cardioprotective gene heat shock transcription factor (HSF1) and its screening method and application. Background technique

[0002] Heart failure is a group of complex clinical syndromes, which is the severe stage of most patients with organic heart disease, and the 5-year survival rate is similar to that of malignant tumors. Once heart failure occurs in heart disease patients, the 1-year mortality rate is 43%, and the 5-year mortality rate reaches 75%, seriously endangering human health. Epidemiological data show that the number of heart failure patients in the world is as high as 22.5 million, and there are 2 million new cases every year. The rapid aging of the population and the increase of various risk factors make ischemic heart disease the most common cause of heart failure. In developed countries, the increase in t...

Claims

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