Therapeutic peptides and vaccines

A technology of vaccines and therapeutic compositions, applied in the direction of antibody medical ingredients, pharmaceutical formulas, medical preparations containing active ingredients, etc., which can solve problems such as vaccine candidates failing to elicit sufficient immune responses

Inactive Publication Date: 2008-08-13
拉皮德医药股份公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Peptide-based vaccine candidate also fails to elicit adequate immune response

Method used

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  • Therapeutic peptides and vaccines
  • Therapeutic peptides and vaccines
  • Therapeutic peptides and vaccines

Examples

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Embodiment Construction

[0027] In contrast to previously studied products and methods, the products and methods disclosed herein exhibit unexpected potent anti-HIV activity and other therapeutic properties. In the following examples, some but not all embodiments of the invention are illustrated.

[0028] The present invention reveals a family of biologically active pentapeptides in the V2 region of gp120 with variable but homologous sequences that block coreceptor binding. In previous studies, it was considered that the V2 region does not play an important role in the binding and infectivity of gp120 to the receptor. Mutants lacking V2 are thought to be infectious (6, 7). In contrast to the V2 loop, the V3 loop has been widely proposed to contain the receptor-binding epitope of gp120 (7-9). It is also believed that such homologous sequences arise from regions other than V2 of gp120 where they may occur.

[0029] The present invention describes formulations comprising one or more peptides having CC...

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Abstract

The present invention discloses compositions of vaccines that broadly induce HIV therapeutics and antibodies that induce antibodies to different HIV clades, and also relates to the identification of HIV gp120-derived short peptide sequence immunogens and the generation of various The capacity of the therapeutic composition. The invention also discloses methods for selecting candidate peptide sequences that may be effective drugs for the treatment of Alzheimer's disease, psoriasis, multiple sclerosis and the cascade of inflammation associated with humans and related retroviruses such as the tropical Other HTLV-1-associated diseases with spastic paralysis.

Description

[0001] This application claims Provisional Application Serial No. 60 / 693,087 filed June 23, 2005; Provisional Application Serial No. 60 / 693,088 filed June 23, 2005 and Provisional Application Serial No. 60 / 693,089 filed June 23, 2005 priority. This application is also related to the application serial number ___ with the title of "Stabilized Alkyl Glycoside Composition and Method" filed on June 23, 2006, the contents of which are incorporated herein by reference. Background of the invention [0002] It is generally accepted that a vaccine capable of protecting against HIV-1 infection and AIDS requires an immunogen that induces high levels of antibodies with strong neutralizing activity against the original isolate of the virus, regardless of its geographic origin, subtype Or genotype specificity, which is not achieved by current vaccine candidates. Therefore, identification of epitopes that mediate broad neutralization is important for ideal vaccine design and development. O...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/21
Inventor C·珀特M·拉夫
Owner 拉皮德医药股份公司
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