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Hyper-concentrated placenta tissue hydrolysate freeze-drying capsules and its preparation method

A placenta, tissue fluid technology, applied in freeze-drying delivery, capsule delivery, drug combination and other directions, can solve the problem of placenta, such as large molecular weight

Inactive Publication Date: 2011-07-27
陈包容
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Therefore, aiming at the problem that the molecular weight of the placenta extracted by SFE technology is still relatively large, the inventor provides a freeze-dried capsule preparation of ultra-concentrated placenta tissue fluid extracted by bio-enzyme technology

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038]Put the placental tissue stock solution into the extraction kettle, pass in 30-40Mpa of carbon dioxide, and extract at 30-40°C for 8-12 hours; after one-stage decompression separation, the operating pressure is 8-12Mpa, and the operating temperature is 30-35 ° C; and then carry out two-stage decompression separation, the condition is that the operating pressure is below 6Mpa, and the operating temperature is 15-25 ° C to obtain the placenta extract. Then the placenta extract was treated with endonuclease TCCRAC (20 / 18) at 30°C for 24 hours to reduce the molecular weight of the main component to below 6000 Daltons. The obtained small molecule extract was freeze-dried at -40°C under a vacuum of 12 Pa to obtain a freeze-dried powder.

[0039] Weigh 80g of phospholipids, 40g of cholesterol and 33g of poloxamer (F68), dissolve with 1000ml of chloroform or dichloromethane to make liposome solution barium salt. Another 80g of extract and 240g of mannitol were passed through a ...

Embodiment 2

[0041] Put the placental tissue stock solution into the extraction kettle, pass in 20-30Mpa of carbon dioxide, and extract at 30-40°C for 8-12 hours; after one-stage decompression separation, the operating pressure is 8-12Mpa, and the operating temperature is 30-35 ° C; and then carry out two-stage decompression separation, the condition is that the operating pressure is below 6Mpa, and the operating temperature is 15-25 ° C to obtain the placenta extract. Then the placenta extract was treated with endonuclease CTGAAG (16 / 14) at 30° C. for 18 hours to reduce the molecular weight of the main component to below 6000 Daltons. The ultrafiltration membrane with a molecular weight cut-off of 6000 Daltons ( U.S. millipore company, standard ultrafiltration system) ultrafiltration extract, make ultrafiltrate through freeze-drying, obtain freeze-dried powder, carry out endonuclease treatment repeatedly with ultrafiltration retentate, carry out ultrafiltration again. Repeat until almost a...

Embodiment 3

[0044] Put the placental tissue stock solution into the extraction kettle, pass in 20-30Mpa of carbon dioxide, and extract at 30-40°C for 8-12 hours; after one-stage decompression separation, the operating pressure is 8-12Mpa, and the operating temperature is 30-35 ° C; and then carry out two-stage decompression separation, the condition is that the operating pressure is below 6Mpa, and the operating temperature is 15-25 ° C to obtain the placenta extract. Then the placenta extract was treated with endonuclease CTTGAG (16 / 14) at 30° C. for 24 hours to reduce the molecular weight of the main component to below 4000 Daltons. The extract was ultrafiltered with an ultrafiltration membrane with a molecular weight cut-off of 4000 Daltons (U.S. millipore company, standard ultrafiltration system), and the ultrafiltration retentate was repeatedly subjected to endonuclease treatment and then ultrafiltration. Repeat this until almost all the extract can pass through the ultrafiltration m...

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Abstract

The invention relates to a manufacture method of a hyperconcentration placental-peptide tissue-fluid freeze-dried capsule, which comprises the steps as follows: (a) placenta tissue stock solution is processed through CO2 supercritical fluid extraction to obtain placental peptide extracts; (b) biological enzyme is utilized to process the placental peptide extracts, and molecular weight is reduced to below 6000 daltons; (c) small molecule extracts which are obtained in the step (b) are processed through freeze drying, so as to obtain the freeze-dried powder; and (d) the freeze-dried powder is manufactured into the hyperconcentration placental-peptide tissue-fluid freeze-dried capsule by adopting the lipidosome preparation method. The capsule and the manufacture method eliminate the problem of inconvenient use and carrying in the prior injection products.

Description

technical field [0001] The invention relates to a health product containing placenta polysaccharide and a method for preparing the health product. Background technique [0002] The placenta Chinese medicine is called Ziheche, which has the functions of regulating human body functions, enhancing resistance, and nourishing vital energy, essence and blood. Placenta is a medicinal ingredient extracted from the placenta, which contains a variety of hormones and biological enzymes. In the past, the extraction of placenta mostly used the method of cooking and concentrating. Through research, the inventor has provided a method for extracting placenta by supercritical carbon dioxide extraction, please refer to Chinese patent 200410096974.0, the placenta extracted by this method has the active components in the extracted placenta will not be lost, and the placenta The advantage of placenta extraction is more thorough. [0003] The present inventor made injections from the placenta ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K9/19A61P37/04A61K35/50A61K9/127
Inventor 陈包容
Owner 陈包容