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Antiallergic lactic acid bacteria

An anti-allergic, Lactobacillus salivarius technology, applied in the direction of bacteria, etc.

Inactive Publication Date: 2012-05-23
PROMD BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Generally, eating products containing lactic acid bacteria (LAB) only has the effect of adjusting the health of the intestinal tract. Although tens of thousands of lactic acid bacteria strains exist in nature, only a few lactic acid bacteria strains have anti-allergic properties

Method used

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  • Antiallergic lactic acid bacteria
  • Antiallergic lactic acid bacteria
  • Antiallergic lactic acid bacteria

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1: Morphological and general properties of five strains of anti-allergic lactic acid bacteria

[0034] According to the results of 16S rDNA sequence analysis and API bacterial identification system analysis, the taxonomic characteristics of the strains were confirmed. It was found that Dongyu strain number PM-A0002 is Lactobacillus acidophilus; Dongyu strain number PM-A0005 is Lactobacillus plus type; Dongyu strain number PM-A0006 is Lactobacillus salivarius; Dongyu strain number PM-A0009 is about formula Lactobacillus; and Dongyu strain number PM-A0013 is Lactobacillus acidophilus. The characteristics of the five strains in morphology and general properties are listed in Table 2:

[0035] Table 2

[0036]

[0037]

Embodiment 2

[0038] Example 2: The effect of anti-allergic lactic acid bacteria on regulating Th1 type immunity by promoting the secretion of interferon gamma (using peripheral blood mononuclear cells as an in vitro efficacy verification platform)

[0039] Detect five strains of anti-allergic lactic acid bacteria: Lactobacillus acidophilus PM-A0002 strain, Lactobacillus gasseri PM-A0005 strain, Lactobacillus salivarius PM-A0006 strain, Lactobacillus johnsonii strain PM-A0009 or Lactobacillus acidophilus PM-A0013 The enhancement effect of strains on Th1 type immunity is to screen the strains with anti-allergic ability by measuring the secretion of interferon gamma after the co-cultivation of human peripheral blood mononuclear cells and anti-allergic lactic acid bacteria. Use the following experimental procedure:

[0040] 1. Take an appropriate amount of human blood, about 200ml each time.

[0041] 2. Take an equal proportion of Ficoll-paque and blood and centrifuge at 400g for 30-40 minute...

Embodiment 3

[0048] Embodiment 3: the effect of anti-allergic lactic acid bacteria on the Th1 type immune ability of the secretion regulation of interleukin (IL-12) (using dendritic cells as an in vitro efficacy verification platform)

[0049] Detect five strains of anti-allergic lactic acid bacteria: Lactobacillus acidophilus PM-A0002 strain, Lactobacillus gasseri PM-A0005 strain, Lactobacillus salivarius PM-A0006 strain, Lactobacillus johnsonii strain PM-A0009 or Lactobacillus acidophilus PM-A0013 The enhancement effect of the strain on Th1 type immunity is determined by measuring the secretion of interleukin-12 (IL-12) after the co-cultivation of human dendritic cells and anti-allergic lactic acid bacteria to screen the strains with anti-allergic ability. Use the following experimental procedure:

[0050] 1. Take an appropriate amount of human blood, about 200ml each time.

[0051] 2. Take an equal proportion of Ficoll-paque and blood and centrifuge at 400g for 30-40 minutes at 18-20°C...

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Abstract

The invention relates to a novellactic acid bacterium strain and a composition containing one or a plurality kinds of the novel lactic acid bacterium, wherein, the strain has the capacity to improve the antianaphylaxis property which is unknown in the prior art, and the composition is a food or a pharmaceutical composition. The invention also discloses a method for filtering and measuring the lactic acid bacterium strains and a method for adjusting and controlling the Th2 type immunologic reaction which is excessive due to the hypersusceptibility by intensifying the Th1 type immunologic reaction.

Description

technical field [0001] The invention relates to an anti-allergic lactic acid bacteria strain composition used in food or medicine, and its use in improving anti-allergic ability. Background technique [0002] In recent years, allergic diseases have been increasing year by year, whether in atopic dermatitis, allergic rhinitis, and bronchial asthma. At present, it is believed that the occurrence of allergic diseases may be related to the progress of civilization, including air pollution and the reduction of infections are some possible reasons for the increase of allergic diseases. The current treatment of asthma mainly relies on drug therapy: such as the use of steroids and drugs that inhibit the release of inflammatory substances from mast cells, bronchodilators and immunotherapy. However, drug treatment, including anti-inflammatory drugs and bronchodilators, still cannot really change the allergic immune response, so it can only be said to be a palliative method. The only...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N1/20
Inventor 苏伟志谢佩珊蔡宜钧吴奇璋陈怡君郭仲伟杨琼英
Owner PROMD BIOTECH