Method of detecting bias in enzyme electrode measurements

Abstract

A method of determining the concentration of an analyte in a fluid test sample that includes providing an electrochemical sensor adapted to measure the analyte in the test sample. The test sample sufficiently covers a counter and working electrode of the electrochemical sensor. A first potential is applied between the counter and working electrodes for a first predetermined time period and the current is measured and the time is recorded. After the first potential is removed or substantially reduced, a second potential is applied between the counter and working electrodes and the current is measured. The concentration of the analyte is determined in the test sample as a function of the current measured. An index is calculated and compared to at least one predetermined parameter to identify when a bias, if any, exceeds a threshold. An error signal or analyte concentration is displayed depending on the comparison.

Description

[0001] This application is a divisional application of the following application: application date February 10, 2004, application number 200410039619.X, title "method for measuring analyte concentration in liquid test sample". technical field [0002] The present invention relates to methods of using biosensors and, more particularly, to methods of detecting bias caused by partially filled electrochemical sensors in determining the concentration of an analyte in a liquid test sample. Background technique [0003] Quantitative determination of analytes in body fluids is important for the diagnosis and maintenance of certain physiological abnormalities. For example, lactate, cholesterol and bilirubin should be monitored for certain individuals. In particular, detection of glucose in body fluids is important for diabetic patients who must frequently check glucose levels in body fluids in order to control their dietary glucose intake. While the remainder of this disclosure will...

AI Technical Summary

Problems solved by technology

Since the amount of analyte (such as glucose) detected by the electrochemical sensor is directly proportional to the current flowing through the detector, incomplete coverage of the electrodes of the electrochemical sensor will lead to deviations in blood sample analyte (such as glucose concentration)

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