Gentamicin gel rubber preparation

Abstract

The invention discloses gel preparation containing gentamycin and poloxamer. The gel preparation contains aminoglycoside antibiotics and poloxamer. In the pharmaceutical composition of the medicines, poloxamer accounts for approximately 21% to 40% of the weight of the composition. Preferably, poloxamer accounts for approximately 23% to 28% of the weight of the composition, and optimally, poloxamer accounts for approximately 25%. The gel preparation can be used for treating Meniere diseases.

Description

field of invention [0001] The invention relates to a pharmaceutical composition containing gentamicin and a preparation method thereof. More specifically, the present invention relates to a new pharmaceutical dosage form—gentamicin gel preparation, which contains gentamicin and poloxamer. Background technique [0002] Meniere's disease is a markedly disabling inner ear disorder. The global incidence rate is 12 / 1000 people (Areberg IK, George G, Pillsburg HC III. The incidence and prevalence of Meniere's disease: a statistical analysis of limits. Otolaryngol Clin North Am, 1980; 13: 597-602.). The clinical manifestations are sudden onset of vertigo, accompanied by a sense of fullness in the affected ear and tinnitus. The frequency of attacks and the interval between attacks are indefinite, and the pattern of attacks is also changeable. During the intermittent period of the disease, patients may have hearing loss and tinnitus. The bilateral incidence is greater than 30% (B...

AI Technical Summary

Problems solved by technology

[0007] The main reasons for analyzing the above differences and confusion are: 1. The activity and pharmacokinetics of gentamicin after intratympanic administration are still unclear; tube, external auditory canal, or septate somewhere in the middle ear cavity that cannot be absorbed by the inner ear, these circumstances make each patient and each dose likely to be different

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