Application of digoxin in medicines for preventing and treating motion sickness and meniere disease

A technology for Meniere's disease and motion sickness, applied in the field of biomedicine, can solve problems such as blurred vision, memory impairment, and large side effects, and achieve the effect of reducing sensitivity

Pending Publication Date: 2021-12-14
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Aiming at the deficiencies in the prior art, this application solves the problem that the effective sites of existing drugs are still not very clear, and the side effects are also relatively large, especially the side effects such as central inhibition, blurred vision, and memory impairment. Drugs and other problems; provide a digoxin in the prevention and treatment of motion sickness, Meniere's disease drug application

Method used

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  • Application of digoxin in medicines for preventing and treating motion sickness and meniere disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A kind of application of digoxin in prevention and treatment of motion sickness and Meniere's disease medicine, the experimental animal adopted is Sprague-Dawley (SD) rat, body weight 200-220g, female, adaptive feeding for 3 days, then carry out rotation stimulation Induce motion sickness and the experiment of Meniere's disease two halo models, take the conditioned taste aversion as a model; Carry out the anti-halo experiment of digoxin again, take the conditioned taste aversion induced by the rotating stimulus as a model, the digoxin ( Amiloride, Aml) was purchased from Sigma-Aldrich Company of the United States, Saccharin sodium (Saccharin sodium) was produced by Tianjin North Food Co., Ltd., and SD rats were provided by the Experimental Animal Center of Nantong University. The steps were as follows:

[0029] Step 1: Allow the rats to drink freely with 0.15% sodium saccharin solution, and measure the drinking amount every 24 hours. Digoxin is given by intraperitoneal i...

Embodiment 2

[0034] A kind of application of digoxin in preventing and treating motion sickness and Meniere's disease medicine, the experimental animal adopted is Sprague-Dawley (SD) rat, body weight 200-220g, female, adaptive feeding 3 days, carry out rotation stimulation then Induce motion sickness and the experiment of two dizzy models of Meniere's disease, take the conditioned taste aversion as a model; Carry out the anti-halo experiment of digoxin again, take the conditioned taste aversion induced by the rotating stimulus as a model, the digoxin ( Amiloride, Aml) was purchased from Sigma-Aldrich Company of the United States, Saccharin sodium (Saccharin sodium) was produced by Tianjin North Food Co., Ltd., and SD rats were provided by the Experimental Animal Center of Nantong University. The steps were as follows:

[0035] Step 1: Allow the rats to drink freely with 0.15% sodium saccharin solution, and measure the drinking amount every 24 hours. Digoxin is given by intraperitoneal injec...

Embodiment 3

[0039] A kind of application of digoxin in preventing and treating motion sickness and Meniere's disease medicine, the experimental animal adopted is Sprague-Dawley (SD) rat, body weight 200-220g, female, adaptive feeding 3 days, carry out rotation stimulation then Induce motion sickness and the experiment of two dizzy models of Meniere's disease, take the conditioned taste aversion as a model; Carry out the anti-halo experiment of digoxin again, take the conditioned taste aversion induced by the rotating stimulus as a model, the digoxin ( Amiloride, Aml) was purchased from Sigma-Aldrich Company of the United States, Saccharin sodium (Saccharin sodium) was produced by Tianjin North Food Co., Ltd., and SD rats were provided by the Experimental Animal Center of Nantong University. The steps were as follows:

[0040] Step 1: Allow the rats to drink freely with 0.15% sodium saccharin solution, and measure the drinking amount every 24 hours. Digoxin is given by intraperitoneal injec...

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Abstract

The invention discloses an application of digoxin in medicines for preventing and treating motion sickness and meniere disease, an experimental animal adopted in an effect experiment is a Sprague-Dawley (SD) rat with the weight of 200-220 g, the rat is female and adaptive to be fed for 3 days, then an experiment of inducing motion sickness and meniere disease two-dizziness model through rotational stimulation is performed, and conditional taste aversion is taken as the model; digoxin anti-dizziness experiment is performed, and the change of the drinking amount of the rat to the 0.15% saccharin sodium solution two days after rotation stimulation is detected by taking the conditional taste aversion induced by rotation stimulation as a model; and digoxin is applied to antagonize the action of rotation stimulation and increased arginine vasopressin and halocorticoid aldosterone on the inner ear, antagonize excessive lymph generation in the inner ear, reduce vestibular stimulation sensitivity, inhibit the occurrence of motion sickness and inhibit the progress of the meniere disease.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of digoxin in medicines for preventing and treating motion sickness and Meniere's disease. Background technique [0002] When a person is passively exercising and receives abnormal vestibular stimulation or / and abnormal visual stimulation, motion sickness will occur, mainly manifested as pale complexion, cold sweat, salivation, apathy, abdominal discomfort, dizziness, nausea, and vomiting. At present, the detailed pathogenesis of motion sickness is still not very clear, and there is still a lack of effective drugs without side effects in the prevention and treatment. The most commonly used drug for prevention and treatment of motion sickness is the antihistamine Dimenhydrinate (tea dimenhydrinate), and the single drug with the best effect is the anticholinergic drug scopolamine, but the effective sites of the above drugs are not very clear. The si...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P27/16A61P25/14
CPCA61K31/7048A61P27/16A61P25/14
Inventor 周鑫姜正林徐丽华任畅
Owner NANTONG UNIVERSITY
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