Application of amiloride in medicines for preventing and treating motion sickness and meniere disease

A technology for Meniere's disease and motion sickness, applied in the field of biomedicine, can solve the problems of side effects (blurred vision, unclear effective site, lack of high-efficiency drugs without side effects, etc.)

Pending Publication Date: 2021-12-17
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Aiming at the deficiencies in the prior art, the present application solves the problem that the active part of the existing drugs is not very clear, and the side effects (blurred vision, memory impairment) are also relatively large, and have a strong central inhibitory effect. Unnecessary or even serious side effects such as damage to hearing and balance functions, and the lack of efficient drugs without side effects in the prevention and treatment of motion sickness; provides a kind of application of amiloride in the prevention and treatment of motion sickness and Meniere's disease

Method used

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  • Application of amiloride in medicines for preventing and treating motion sickness and meniere disease
  • Application of amiloride in medicines for preventing and treating motion sickness and meniere disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A kind of application of amiloride in prevention and treatment of motion sickness, Meniere's disease medicine, the experimental animal that described amiloride adopts in the treatment effect experiment of prevention and treatment motion sickness, Meniere's disease medicine is Sprague-Dawley (SD ) rats, weighing 200-220g, female, were fed adaptively for 3 days, and then carried out experiments on two dizzy models of motion sickness and Meniere's disease induced by rotational stimulation and aldosterone stimulation, using conditioned taste aversion as a model; Lowry's anti-dizziness experiment, using the conditioned taste aversion induced by rotating stimuli as a model, the steps are:

[0030] Step 1: 0.15% sodium saccharin solution allowed rats to drink freely, and the drinking amount was measured once every 24 hours. After detecting the drinking amount of 0.15% sodium saccharin solution in rats for two days, aldosterone was given by intraperitoneal injection on the 3rd d...

Embodiment 2

[0037] A kind of application of amiloride in prevention and treatment of motion sickness, Meniere's disease medicine, the experimental animal that described amiloride adopts in the treatment effect experiment of prevention and treatment motion sickness, Meniere's disease medicine is Sprague-Dawley (SD ) rats, weighing 200-220g, female, were fed adaptively for 3 days, and then carried out experiments on two dizzy models of motion sickness and Meniere's disease induced by rotational stimulation and aldosterone stimulation, using conditioned taste aversion as a model; Lowry's anti-dizziness experiment, using the conditioned taste aversion induced by rotating stimuli as a model, the steps are:

[0038] Step 1: 0.15% sodium saccharin solution allowed rats to drink freely, and the drinking amount was measured once every 24 hours. After detecting the drinking amount of 0.15% sodium saccharin solution in rats for two days, aldosterone was given by intraperitoneal injection on the 3rd d...

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Abstract

The invention discloses an application of amiloride in medicines for preventing and treating motion sickness and meniere disease. The application comprises the steps that an experimental animal adopted in an effect experiment is a Sprague-Dawley (SD) rat with the weight of 200-220 g, and the rat is female and adaptively fed for 3 days; then an experiment of inducing motion sickness and meniere disease two dizziness models through rotation stimulation and aldosterone stimulation is carried out, and conditional taste aversion is taken as the model; and an anti-dizzy experiment of amiloride is carried out, conditional taste aversion induced by rotation stimulation is taken as a model, and the pathogenesis of the meniere disease is directly related to the action of lymphatic hydrops in the inner ear and aldosterone in the inner ear, so that a research result further supports the action of treating the meniere disease by using the amiloride.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of amiloride in medicines for preventing and treating motion sickness and Meniere's disease. Background technique [0002] According to the different means of transportation, motion sickness can be divided into motion sickness, seasickness, airsickness, simulator sickness, and aerospace motion sickness. The main early manifestations are pale complexion, cold sweat, salivation, abdominal discomfort, and dizziness, which will eventually induce nausea and vomiting. . Although motion sickness can be gradually alleviated after leaving the sports environment, it obviously affects people's normal travel and work in special environments such as aviation, aerospace and navigation. At present, there is still a lack of highly effective drugs without side effects in the prevention and treatment of motion sickness. The existing effective anti-motion sickness ...

Claims

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Application Information

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IPC IPC(8): A61K31/4965A61P27/16A61P25/14
CPCA61K31/4965A61P27/16A61P25/14
Inventor 周鑫姜正林徐丽华任畅
Owner NANTONG UNIVERSITY
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