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Compositions and methods for treating, controlling, reducing, or ameliorating infections and sequelae thereof

A technology of glucocorticoids and receptor agonists, applied in the field of treatment, composition of inflammation, composition for reducing or improving infection and its sequelae, and control

Inactive Publication Date: 2009-09-02
BAUSCH & LOMB INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Chronic administration of glucocorticoids may also lead to drug-induced osteoporosis by preventing intestinal calcium absorption and inhibiting bone formation

Method used

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  • Compositions and methods for treating, controlling, reducing, or ameliorating infections and sequelae thereof
  • Compositions and methods for treating, controlling, reducing, or ameliorating infections and sequelae thereof
  • Compositions and methods for treating, controlling, reducing, or ameliorating infections and sequelae thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0221] Two mixtures I and II were prepared respectively by mixing the ingredients listed in Table 1. 5 parts by weight of Mixture I were mixed with 20 parts by weight of Mixture II for 15 minutes or more. The pH of the combined mixture was adjusted to 6.2-6.4 using 1 N NaOH to obtain the composition of the invention.

[0222] Table 1

[0223] Element

Embodiment 2

[0225] Two mixtures I and II were prepared respectively by mixing the ingredients listed in Table 2. 5 parts by weight of Mixture I were mixed with 20 parts by weight of Mixture II for 15 minutes or more. The pH of the combined mixture was adjusted to 6.2-6.4 using 1 N NaOH to obtain the composition of the invention.

[0226] Table 2

[0227] Element

Embodiment 3

[0229] Two mixtures I and II were prepared respectively by mixing the ingredients listed in Table 3. 5 parts by weight of Mixture I were mixed with 20 parts by weight of Mixture II for 15 minutes or more. The pH of the combined mixture was adjusted to 6.2-6.4 using 1 N NaOH to obtain the composition of the invention.

[0230] table 3

[0231] Element

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PUM

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Abstract

A composition for treating, controlling, reducing, ameliorating, or alleviating infections and their inflammatory sequelae comprises a dissociated glucocorticoid receptor agonist (''DIGRA'') and an anti-infective agent, such as an antibacterial, antiviral, antifungal, antiprotozoal agent, or a combination thereof. The composition can be formulated for topical application, injection, or implantation.

Description

[0001] cross reference [0002] This application claims priority to Provisional Patent Application 60 / 836,110, filed August 7, 2006, which is hereby incorporated by reference. Background of the invention [0003] The present invention relates to compositions and methods for treating, controlling, alleviating or ameliorating infection and its sequelae. In particular, the present invention relates to compositions comprising isolated glucocorticoid receptor agonists ("DIGRAs") and methods of using such compositions to treat, control, alleviate or ameliorate infections and their sequelae. Furthermore, the present invention relates to compositions and methods for treating, controlling, alleviating or ameliorating ocular infections and resulting inflammations using such DIGRAs. [0004] The interface between an organism and its environment is large, so there are many potential opportunities for the entry of toxic pathogens from the environment. The external tissues of the eye form...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4725A61K45/06A61P27/00A61P31/00A61P31/04A61P33/00
CPCA61K45/06A61K31/4709A61K31/4725A61P27/00A61P27/02A61P27/14A61P29/00A61P31/00A61P31/04A61P31/10A61P31/22A61P33/00A61P33/02A61P33/04A61K2300/00
Inventor 胡珍泽K·W·沃德G·菲利普斯R·凯尔波拉
Owner BAUSCH & LOMB INC
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