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Htsnps for determining a genotype of cytochrome P450 1a2, 2A6 and 2D6, PXR and UPD-glucuronosyltransferase 1A gene and multiplex genotyping methods using thereof

A single nucleotide polymorphism, haplotype technology, applied in biochemical equipment and methods, microbial determination/inspection, etc., can solve problems such as not much research

Inactive Publication Date: 2012-09-05
申载国
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are not many studies on genetic variants in the genes of Koreans, their corresponding haplotypes, and htSNP selection according to each haplotype

Method used

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  • Htsnps for determining a genotype of cytochrome P450 1a2, 2A6 and 2D6, PXR and UPD-glucuronosyltransferase 1A gene and multiplex genotyping methods using thereof
  • Htsnps for determining a genotype of cytochrome P450 1a2, 2A6 and 2D6, PXR and UPD-glucuronosyltransferase 1A gene and multiplex genotyping methods using thereof
  • Htsnps for determining a genotype of cytochrome P450 1a2, 2A6 and 2D6, PXR and UPD-glucuronosyltransferase 1A gene and multiplex genotyping methods using thereof

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Embodiment Construction

[0098] Hereinafter, exemplary embodiments of the present invention will be described with reference to the drawings, in which the same reference numerals denote the same elements, and repetitive descriptions will be avoided as much as possible.

[0099] The present invention can be used to determine the genotype of the CYP1A2 gene found in Koreans by analyzing the variants of the Korean CYP1A2 gene, select htSNP as the optimal tag group for each haplotype, and confirm its availability. In addition, the present invention can be used to determine a new haplotype of the human CYP1A2 gene.

[0100] The method of the present invention for selecting htSNP of human CYP1A2 gene is as follows:

[0101] (a) Collect biological samples from the subject;

[0102] (b) Extract nucleic acid from the sample collected in operation (a);

[0103] (c) PCR with primers, which uses the nucleic acid extracted in operation (b) as a template to amplify the human CYP1A2 gene or its fragments;

[0104] (d) Determi...

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Abstract

The present invention relates to htSNPs for determining a genotype of cytochrome P450 1A2 (CYP1A2), 2A6 (CYP2A6) and 2D6 (CYP2D6), PXR and UDP- glucuronosyltransf erase Ia (UGTlA) genes and a gene chiThe present invention relates to htSNPs for determining a genotype of cytochrome P450 1A2 (CYP1A2), 2A6 (CYP2A6) and 2D6 (CYP2D6), PXR and UDP- glucuronosyltransf erase Ia (UGTlA) genes and a gene chip using the same, and more particularly, to a selection method of htSNPs for determining a haplotype of human CYP1A2, CYP2A6, CYP2D6, PXR and UGTlA genes, a method of determining a genotype of the genp using the same, and more particularly, to a selection method of htSNPs for determining a haplotype of human CYP1A2, CYP2A6, CYP2D6, PXR and UGTlA genes, a method of determining a genotype of the genes by using the htSNPs and a gene chip therefor.es by using the htSNPs and a gene chip therefor.

Description

Technical field [0001] The device and method of the present invention relate to haplotype tag single nucleotide polymorphism (htSNP) and the genotype of cytochrome P450 1A2, 2A6 and 2D6, PXR and UDP-glucuronyltransferase 1A gene Gene chip, more specifically, relates to a method for determining the haplotypes of human CYP1A2, CYP2A6, CYP2D6, NR1I2 (=PXR) and UGT1A gene haplotype selection method of htSNP, a method for determining the genotype of the gene and a method for The method of gene chip. Background technique [0002] Due to genetic diversity, individuals will respond differently to the toxicity and effects of drugs. Therefore, it is necessary to consider the effects of important medicinal proteins with respect to genetic diversity in the initial development of drugs, because this can reduce the possibility of drug development failure. Haplotype is one of the factors that determine the genetic diversity between individuals. Haplotype refers to the combination of polymorp...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/68
CPCC12Q1/6827C12Q1/6883C12Q2600/156C12Q2600/172
Inventor 申载国张仁珍李相燮郑惠恩车仁浚金佑永芮晟洙金垠泳车恩暎孙知弘崔银贞金江美郑玄朱
Owner 申载国
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