Ubenimex fat emulsion injection and preparation method thereof

A technology of ubenimex and fat emulsion, which is applied in the field of medicine and biology, can solve the problems of increasing patient pain and medical costs, poor water solubility of ubenimex, and the drug is easily affected by food, etc., and achieves a simple and easy preparation process, Improve clinical application value, good water solubility effect

A technology of ubenimex and fat emulsion, which is applied in the field of medicine and biology, can solve the problems of increasing patient pain and medical costs, poor water solubility of ubenimex, and the drug is easily affected by food, etc., and achieves a simple and easy preparation process, Improve clinical application value, good water solubility effect

CN101601649BInactive Publication Date: 2011-05-04SHANDONG UNIV
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  • Ubenimex fat emulsion injection and preparation method thereof
  • Ubenimex fat emulsion injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A kind of ubenimex fat emulsion of embodiment 1, it consists of:

[0038] Ubenimex 100mg

[0039] Soybean oil for injection 10g

[0040] Medium chain oil 10g

[0041] Oleic acid 1.0g

[0042] Soy Lecithin 1.2g

[0043] Glycerin 2.2g

[0044] Add water for injection to 100ml

[0045] The preparation method of above-mentioned fat emulsion is as follows:

[0046] 1) mixing soybean oil for injection, medium chain oil and stabilizer oleic acid, stirring evenly to make an oil phase;

[0047] 2) Mix the emulsifier soybean lecithin and the isotonic regulator glycerin, add an appropriate amount of water, stir evenly, and make the water phase;

[0048] 3) The oil phase is poured into the water phase under stirring, and high-speed shearing is made into colostrum;

[0049] 4) Add Ubenimex to water dispersed with emulsifier, and shear at high speed to obtain a drug suspension;

[0050] 5) Add the drug suspension to the colostrum, shear at high speed to obtain the drug-loade...

Embodiment 2

[0053] A kind of ubenimex fat emulsion of embodiment 2, it consists of:

[0054] Ubenimex 300mg

[0055] Soybean oil for injection 10g

[0056] Medium chain oil 10g

[0057] Oleic acid 1.0g

[0058] Soy Lecithin 1.2g

[0059] Glycerin 2.2g

[0060] Add water for injection to 100ml

[0061] The preparation method is the same as in Example 1, and the number of times of high-pressure milk homogenization is 20 times, and the particle size of the obtained fat emulsion is 228.4nm.

Embodiment 3

[0062] Embodiment 3 A kind of Ubenimex fat emulsion, its composition is the same as that of Example 1, and its preparation method is the same as that of Example 1, but the pH regulator is sodium bicarbonate, and the number of times of high-pressure milk homogenization is 5 times, and the particle size of the obtained fat emulsion is 285.6nm, such as figure 1 shown.

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Abstract

The invention discloses a ubenimex fat emulsion injection, comprising ubenimex, oil for injection, emulsifier, stabilizer, isoosmotic adjusting agent and water, wherein, the concentration of the ubenimex is 0.05-10g / ml, the concentration of the oil for injection is 5-30g / ml, the concentration of the emulsifier is 0.8-3.0g / ml, the concentration of the stabilizer is 0.1-2.0g / ml, and the concentration of the isoosmotic adjusting agent is 2-3g / ml. Through measuring, the quality and the appearance of the fat emulsion injection of the invention are uniform, the average particle diameter is about 300nm, and the pH value is 5.0-9.0, thus, the fat emulsion injection can be used for injection. The ubenimex fat emulsion injection has obvious anti-tumor function. According to the characteristics of common fat emulsion injection, the ubenimex fat emulsion injection as an anti-tumor medicine also has the functions of slow releasing, targeting, providing organisms with energy and the like.

Description

technical field [0001] The invention relates to an ubenimex fat emulsion injection and a preparation method thereof, belonging to the field of medical biotechnology. Background technique [0002] At present, effective measures to conquer cancer include surgery, radiotherapy, chemotherapy, etc., but they all have their limitations. For example, radiotherapy and chemotherapy generally have toxic side effects such as killing healthy red and white blood cells, liver and kidney toxicity, and nervous system damage. Therefore, the development of effective anticancer drugs has become a long-term key research topic in the world's medical circles. When the fourth treatment mode of cancer - biological therapy received attention, Ubenimex API and capsules (trade name Baishixin) made a major breakthrough in this field. As a biological response modifier, Ubenimex has It has the characteristics of definite curative effect, clear mechanism of action, extremely low toxicity and convenient a...

Claims

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Application Information

Patent Timeline
04 May 2011
Publication
CN101601649B
IPC
A61K9/107; A61K31/198; A61K47/44; A61P35/00
Inventors
张娜; 孙晓利