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Vitamin D* solid dispersion peridium patch and method for preparing the same

A technology of solid dispersion and solid dispersion carrier, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas. The effect of uniform quality appearance

Active Publication Date: 2011-04-20
重庆市天龙牧业科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016]Due to the aforementioned reasons, the use of general film production methods cannot effectively solve the problems of denaturation and deterioration, and the produced D2 tablets Quantitative and qualitative detection cannot be carried out, resulting in uncontrollable quality, which will certainly limit its clinical application

Method used

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  • Vitamin D* solid dispersion peridium patch and method for preparing the same
  • Vitamin D* solid dispersion peridium patch and method for preparing the same
  • Vitamin D* solid dispersion peridium patch and method for preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] Vitamin D 2 0.3125g

[0072] PEG-6000 100g

[0073] Starch 2500g

[0074] Calcium hydrogen phosphate 2250g

[0075] Ethanol 75g

[0076] Magnesium Stearate 100g

[0077] Talc powder 50g

[0078] Make 10000 pieces

[0079] Prepared as follows:

[0080] 1) Weigh the prescribed amount of PEG-6000 and put it in an 80°C water bath for 40 minutes until it melts completely.

[0081] 2) Add prescribed amount of vitamin D while hot 2 , Stir quickly until the mixture is uniform, and at the same time, ultrasonic waves can be used for 5 minutes to accelerate the solid dispersion speed and dispersion rate.

[0082] 3) Put the homogeneously mixed liquid dispersion in the freezer of the refrigerator for quick freeze-drying.

[0083] 4) After freeze-drying into blocks, transfer to another wide-mouth container, and dry in a vacuum oven at 40°C for 5-6 hours.

[0084] 5) Pound the dried dispersion into powder with a glass rod, and pass through a 80-mesh sieve. Store in a dr...

Embodiment 2、3、4

[0091] Components used in the embodiment of table 1

[0092] Example

[0093] Embodiment 5, 6, 7

Embodiment 5、6、7

[0095] Components used in the embodiment of table 2

[0096] Example

5

6

7

Vitamin D 2

0.3125g

0.3125g

0.3125g

solid dispersion carrier

Polyethylene glycol 100g

Povidone 100g

Surfactant 100g

filler

Starch + calcium hydrogen phosphate 4450g

Powdered sugar 4450g

Dextrin 4450g

Adhesive

Starch slurry 50g

Starch slurry 50g

Cellulose 50g

humectant

Ethanol 75ml

Ethanol 75ml

Distilled water 75ml

lubricant

Magnesium stearate 100g

Magnesium stearate 100g

Magnesium Stearate 100g

Glidant

Talc powder 50g

Micropowder silica gel 50g

Hydrogenated Vegetable Oil 50g

disintegrant

Dry starch 250g

Sodium starch 250g

Cellulose 250g

[0097] In the foregoing embodiments, the solid dispersion carrier used can also be replaced by organic acid, sugar alcohol, cellulose, polyacrylic acid, and resin; the filler used can also ...

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PUM

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Abstract

The invention relates to Vitamin D2 solid dispersion coated tablet and the preparation method thereof, belonging to pharmaceutical preparation technical field. The tablet contains Vitamin D2 and pharmaceutical excipient, with Vitamin D2 as the active component. Every ten thousand tablets contain 0.3125g of Vitamin D2, 100g of PEG-6000, 2500g of starch, 2250g of phosphoric acid calcium hydrogen, 75ml of alcohol, 100g of magnesium stearate and 50g of talc. The invention has a simple preparation method, according to which Vitamin D2 is coated to produce tablets. The Vitamin D2 tablets prepared in the method has obvious treating effects and can be taken orally. The toxicity is low and the bioavailability is greatly enhanced. Besides, the tablet has the functions of sustaining, targeting, energy provision for human organism, etc.

Description

technical field [0001] The present invention relates to vitamin D 2 A solid dispersion coated tablet and a preparation method thereof belong to the technical field of pharmaceutical preparations. Background technique [0002] A lack of vitamin D in the body can cause rickets, tetany and rickets. Vitamin D mainly has the following physiological functions: (1) Improve the body's absorption of calcium and phosphorus, and make the levels of plasma calcium and phosphorus reach saturation. (2) promotes growth and bone calcification, and promotes healthy teeth; (3) increases phosphorus absorption through the intestinal wall and increases phosphorus reabsorption through the renal tubules; (4) maintains normal levels of citrate in the blood; (5) Prevents loss of amino acids through the kidneys. [0003] Vitamin D 2 It is mainly used for the treatment of rickets, tetany and rickets. Vitamin D 2 It is an essential vitamin for the human body and belongs to steroid hormones. Its ma...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/592A61K9/20A61K47/36A61K47/38A61K47/44A61P3/02
Inventor 刘娟
Owner 重庆市天龙牧业科技有限公司
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