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A novel combination of epimedium-derived-flavonoids-fractions for prevention of steroid-induced osteonecrosis

A technology of epimedium and icariin, applied in the field of Wushan epimedium extract, can solve problems such as poor postoperative prognosis

Active Publication Date: 2010-02-03
GUOYAOJITUAN TONGJITANG (GUIZHOU) PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Total joint replacement is the last option for the treatment of osteonecrosis, however postoperative outcomes are poor in steroid-treated patients with osteonecrosis (7, 13-14)

Method used

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  • A novel combination of epimedium-derived-flavonoids-fractions for prevention of steroid-induced osteonecrosis
  • A novel combination of epimedium-derived-flavonoids-fractions for prevention of steroid-induced osteonecrosis
  • A novel combination of epimedium-derived-flavonoids-fractions for prevention of steroid-induced osteonecrosis

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Experimental program
Comparison scheme
Effect test

Embodiment

[0136] compound

[0137] Seven prenyl flavonoid glycosides were extracted from Epimedium wushanense, and identified as Epimedin A(1), Vancouverin F(2), Epimedin A(3), Epimedin B(4) , epimedin C (5), icariin (6) and baohuoside-I (7), as shown in Figure 1.

[0138] In the HPLC spectrum, the percentages of the area under the curve (AUC) of each compound at 270 nm were 1.8%, 1.0%, 1.2%, 1.5%, 4.2%, 80.9% and 2.1%, respectively. The inventors of the present invention found that the study of the HPLC-UV-MS / MS spectra of the flavonoid fractions from Epimedium wushanense could rapidly identify 92.7% of the components ( FIGS. 1-3 ).

[0139] Synthesis of the pharmaceutical composition of the present invention

[0140] plant material

[0141] The leaves of Epimedium wushanense were collected from Lei Shan, Guizhou Province, China, which is a cultivation site with Good Agricultural Practice (GAP) certification for Epimedium wushanense, and authorized by the School of Chinese Materia M...

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Abstract

The present invention relates to novel pharmaceutical compositions comprising Epimedium wushanense Ying extracts, their methods of preparation, and their use in inhibiting thrombosis and lipid deposition. Also provided by the present invention is a method of preventing or treating steroid-associated osteonecrosis with the use of the pharmaceutical composition of the present invention. The preparation method of the present invention is stable and provides reproducible results, both in small scale extraction and large scale extraction.

Description

technical field [0001] The present invention relates to an extract of Epimedium wushanense, a pharmaceutical composition comprising the extract of Epimedium wushanense, a method for preparing a pharmaceutical composition containing the extract of Epimedium wushanense and their application, specifically for inhibiting thrombus Formation and lipid deposition, more specifically, for the prevention or treatment of steroid-induced osteonecrosis. Background technique [0002] Steroids are commonly used to treat a variety of medical conditions. Pulse steroids are often prescribed for severe infectious diseases such as Severe Acute Respiratory Syndrome (SARS) and Acquired Immunodeficiency Syndrome (AIDS), or for severe infectious diseases such as Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA ) and other chronic autoimmune diseases (1-4). [0003] Inevitably, steroid-induced osteonecrosis is frequently reported (5-9), which has recently been highlighted after the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/296A61K127/00A61K31/35A61K31/70C07H17/07C07H1/08A61P3/06A61P7/02A61P19/10
CPCC07H1/08C07H17/07A61K36/296A61K31/35A61K31/70A61P3/06A61P7/02A61P19/10
Inventor 秦岭王晓春张戈姚新生盛辉王新峦
Owner GUOYAOJITUAN TONGJITANG (GUIZHOU) PHARMA CO LTD
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