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Enrofloxacin double emulsion for livestock and preparation method thereof

A technology of enrofloxacin and double emulsion is applied in the field of veterinary enrofloxacin double emulsion and its preparation, and achieves the effects of good compliance, high bioavailability and reducing the number of administrations

Active Publication Date: 2011-05-25
BEIJING DABEINONG ANIMAL HEALTH TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The invention solves the problem that pigs cannot take enrofloxacin orally, improves the drug effect, prolongs the action time of the drug, and provides a good palatability, high efficiency and long-acting enrofloxacin oral preparation for veterinary clinic

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 1) Weigh 2.5g of enrofloxacin, add 20mL of distilled water, adjust the pH value to 12.0 with sodium hydroxide to dissolve, and take another 30mL of soybean oil and 2.5g of Span-80 and emulsify in a high-pressure milk homogenizer for 15min to obtain W / O colostrum;

[0024] 2) Take 50 mL of distilled water, add 2.5 g of Tween-80, 5 g of PEG-4000, 0.2 g of sodium sulfite, 0.1 g of ethylparaben, and 0.03 g of sodium saccharin to obtain an external aqueous phase solution;

[0025] 3) Put the obtained W / O type colostrum and the external aqueous phase solution into a high-pressure homogenizer or a colloid mill for emulsification, and then obtain the enrofloxacin double emulsion.

Embodiment 2

[0027] 1) Weigh 0.5g of enrofloxacin, add 5mL of distilled water, adjust the pH value to 12.0 with sodium hydroxide to dissolve, and take another 5mL of peanut oil and 0.5g of calcium stearate and emulsify in a high-pressure homogenizer for 15min to obtain W / Type O colostrum;

[0028] 2) Take 90 mL of distilled water, add 0.5 g of sodium lauryl sulfate, 0.5 g of sodium carboxymethyl cellulose, 0.2 g of sodium thionate, 0.1 g of ethylparaben, and 0.03 g of sodium saccharin to obtain an external aqueous phase solution ;

[0029] 3) Put the obtained W / O type colostrum and the external aqueous phase solution into a high-pressure homogenizer or a colloid mill for emulsification, and then obtain the enrofloxacin double emulsion.

Embodiment 3

[0031] 1) Weigh 2g of enrofloxacin, add 10mL of distilled water, adjust the pH value to 12.0 with potassium hydroxide and dissolve, take another 15mL of sesame oil and 3g of Span-60 and add them to a high-pressure homogenizer for emulsification for 15min to obtain the W / O type colostrum;

[0032] 2) Take 75mL of distilled water, add Maize-52 4g, PVP k30 2g, sodium sulfite 0.2g, methylparaben 0.15g, and sucrose 10g to obtain an external aqueous phase solution;

[0033] 3) Put the obtained W / O type colostrum and the external aqueous phase solution into a high-pressure homogenizer or a colloid mill for emulsification, and then obtain the enrofloxacin double emulsion.

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Abstract

The invention relates to an enrofloxacin double emulsion for livestock and a preparation method thereof, wherein the enrofloxacin double emulsion belongs to the field of antibiotic preparations for livestock. The W / O / W type double emulsion is prepared by using enrofloxacin as active ingredients and adding oil phase, emulsifier, stabilizer and the like. The enrofloxacin double emulsion for livestock can better cover the bitter taste of the enrofloxacin, improves the adaptation of oral drugs for livestock, can better control the diffusion rate of the drugs to play a role of slow release, and better adapts different clinical drugs requirements. Clinical tests show that the invention can overcome phenomena of food refusal and poor appetite of taste acuity animals of pigs and the like, therebyensuring the dosage, improving the medicine effect, and achieving the purpose of ideal treatment. Meanwhile, because of a certain slow release function, the frequency for medicine administration can be reduced, and the invention provides an efficient and long-acting enrofloxacin preparation for clinical veterinarian.

Description

technical field [0001] The invention belongs to the field of veterinary antibiotic preparations, and relates to a veterinary enrofloxacin double emulsion and a preparation method thereof. Background technique [0002] Enrofloxacin (Enrofloxacin), chemical name 1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinoline Phyloline carboxylic acid, also known as ethyl ciprofloxacin, enrofloxacin. It is the third generation of fluoroquinolones, and it is a bactericidal broad-spectrum antibacterial drug for animals. The absorption of oral administration and intramuscular injection is rapid and relatively complete, and the blood drug concentration reaches the peak within 0.5--2 hours. Enrofloxacin is eliminated through renal and non-renal means, about 15% - 50% of the original drug is excreted through urine. The metabolism in animals is mainly to remove the ethyl group and become ciprofloxacin. This product is a broad-spectrum bactericidal drug, which has sp...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/496A61K9/113A61P31/04
Inventor 田玲莫云刘澜周德刚葛冰张俊儒葛代兴邓利斌黄建茹丛日刚庞加春
Owner BEIJING DABEINONG ANIMAL HEALTH TECH
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