Application of sesame oil in preparing medicinal preparation for preventing glucocorticoid skin aging-like change

Abstract

The invention relates to an application of sesame oil in preparing a medicinal preparation for preventing glucocorticoid skin aging-like change. Researches show that the functions such as skin growthinhabitation, obvious epidermis layer thinning, reduction and breakage of elastic fibers and obvious reduction of the content of skin hydroxyproline of rats are caused by the application of glucocorticoid; and when glucocorticoid is rendered, and sesame oil is rendered simultaneously for prevention, the result shows that the above functions are obviously improved with the use of sesame oil. Therefore, the fact that sesame oil can be used for preparing the medicinal preparation for preventing glucocorticoid skin aging-like change is provided by the invention, thereby being used for preventing medical skin decrepitude and skin aging due to various reasons, whitening and beautifying, protecting skin elasticity, and keeping tender, delicate and smooth skin. When being used as medicine or health care food for preventing skin decrepitude, the sesame oil can be prepared into clinical or other acceptable medicinal preparations, such as anyone of pills, capsules, injections, tablets, pills, dissolved medicines, granular formulations and skin external preparations for clinical application. The sesame oil can also be used as an auxiliary material of glucocorticoid medical preparation, and canbe added into medical preparation of glucocorticoid to form a novel glucocorticoid medical preparation for clinical application.

Description

technical field [0001] The invention relates to the application of sesame oil in the preparation of pharmaceutical preparations for preventing and treating glucocorticoid skin aging-like changes. Background technique [0002] Glucocorticoids are clinically commonly used drugs. In the treatment of skin diseases, glucocorticoids are very important drugs. However, long-term application can lead to local skin atrophy, thinning and other aging-like lesions. There have been many reports on this. Observations have been made, but there is no good prevention and control strategy so far. Sesame has been considered as a healthy food since ancient times, and black sesame can be used as medicine. Compared with other vegetable oils, sesame oil has higher stability. The main reason is that sesame oil contains sesamin substances, which are a special type of endogenous antioxidant substances in sesame oil. In addition to having strong antioxidant properties , can also regulate lipid metabo...

AI Technical Summary

Problems solved by technology

However, whether it can prevent and treat glucocorticoid skin aging-like changes has never been reported. In our research on the prevention and treatment of glucocorticoid adverse reactions, we found that sesame oil has a good effect on the skin aging-like changes caused by glucocorticoids. Preventive effect, the application of prednisone acetate significantly thinned the skin epidermis of rats, the elastic fibers were reduced and broken, and the content of hydroxyproline in the skin was significantly reduced. When prednisone acetate was applied at the same time as sesame oil, the skin of rats could be seen to thicken , the percentage of elastic fiber area increases, and the skin aging-like changes are significantly reduced. This finding suggests that sesame oil can provide a good pharmaceutical preparation for us to overcome the skin aging-like lesions caused by glucocorticoids, and it also provides us with sesame oil. Lays the foundation for development into skin care and beauty products

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