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Injection for treating high fever syndrome of pigs and preparation method thereof

A porcine hyperthermia syndrome and injection technology, which is applied in the field of porcine hyperthermia syndrome injection and its preparation, can solve the problems of low cure rate, total herd destruction, high mortality, etc., and achieve the elimination of pathogenic viruses, reduce losses, The effect of relieving fever symptoms

Inactive Publication Date: 2011-06-15
ZHENGZHOU HOUYI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disease is highly contagious, with a high mortality rate and a low cure rate. In severe cases, the entire flock may even be wiped out, causing huge economic losses to the pig industry.
[0003] At present, there is no specific drug for porcine hyperthermia syndrome, and some antibiotics are often used in clinical treatment. In recent years, due to the large number of clinical drug-resistant strains, the treatment effect is often not ideal

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Accurately weigh 20 g of isatidis extract, 25 g of ephedra extract, 10 g of Houttuynia cordata extract, 15 g of levofloxacin hydrochloride, 15 g of isoprinosine, and 20 g of baicalin.

[0031] The preparation method is as follows:

[0032] (1) Mix Radix isatidis extract, Ephedra extract and Houttuynia cordata extract evenly, add 100ml of distilled water to dissolve, add 300ml of 95% ethanol, stir for 1.5 hours, and place overnight at 4°C;

[0033] (2) Filter the mixed solution obtained in step (1), and concentrate the filtrate to about 200ml at 60°C under reduced pressure;

[0034] (3) Accurately weigh 40ml of Tween-80, add to the concentrated solution obtained in step (2), heat to 60°C, and stir for 1 hour;

[0035] (4) levofloxacin hydrochloride and isoprinosine were dissolved with 30ml of distilled water respectively, and added in the mixed solution of step (3) gained;

[0036] (5) Baicalin was stirred with 80ml of distilled water to form a suspension, and 1mol / L N...

Embodiment 2

[0042] Accurately weigh 15g of Radix isatidis extract, 20g of ephedra extract, 5g of Houttuynia cordata extract, 10g of levofloxacin hydrochloride, 5g of isoprinosine, and 10g of baicalin.

[0043] The preparation method is as follows:

[0044] (1) Mix Radix isatidis extract, Ephedra extract and Houttuynia cordata extract evenly, add 70ml of distilled water to dissolve, add 210ml of 95% ethanol, stir for 1 hour, and place overnight at 4°C;

[0045] (2) Filter the mixed solution obtained in step (1), and concentrate the filtrate to about 140ml at 50°C under reduced pressure;

[0046] (3) Accurately weigh 10ml of Tween-80, add to the concentrated solution obtained in step (2), heat to 55°C, and stir for 1 hour;

[0047] (4) levofloxacin hydrochloride and isoprinosine were dissolved with 25ml and 10ml of distilled water respectively, and added in (3) gained mixed solution;

[0048] (5) Baicalin is stirred with 30 ml of distilled water to form a suspension, and 1mol / L NaOH solut...

Embodiment 3

[0054] Accurately weigh 30g of Radix isatidis extract, 40g of ephedra extract, 20g of Houttuynia cordata extract, 20g of levofloxacin hydrochloride, 20g of isoprinosine, and 30g of baicalin.

[0055] The preparation method is as follows:

[0056] (1) Mix Radix isatidis extract, Ephedra extract and Houttuynia cordata extract evenly, add 120ml of distilled water to dissolve, add 360ml of 95% ethanol, stir for 2 hours, and place overnight at 4°C;

[0057] (2) Filter the mixed solution obtained in step (1), and concentrate the filtrate to about 240ml at 80°C under reduced pressure;

[0058](3) Accurately weigh 100ml of Tween-80, add to the concentrated solution obtained in step (2), heat to 50°C, and stir for 2 hours;

[0059] (4) levofloxacin hydrochloride and isoprinosine were dissolved with 50ml of distilled water respectively, and added in (3) gained mixed solution;

[0060] (5) Baicalin is stirred with 100 ml of distilled water to form a suspension, and 1mol / L NaOH solution...

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Abstract

The invention discloses an injection for treating high fever syndrome of pigs and a preparation method thereof. Every 1,000ml of injection comprises the following raw materials: 15-30g of indigowoad root extract, 20-40g of Chinese ephedra herb extract, 5-20g of heartleaf houttuynia herb extract, 10-30g of baicalin, 5-20g of Isoprinosine and 10-20g of levofloxacin hydrochloride. The injection is used for preventing and treating viral diseases and bacterial disease of live pigs, especially has unique curative effect on high fever syndrome of pigs, caused by heavy infection, final decay, and thelike of the viral diseases. In addition, the invention adopts an injection method, thereby solving the problem that the treating aim is difficult to achieve because ill pigs are difficult to eat effective drug dose by adding drugs in feed.

Description

technical field [0001] The invention relates to a veterinary drug, in particular to an injection for treating porcine hyperthermia syndrome and a preparation method thereof. Background technique [0002] Porcine hyperthermia syndrome is essentially a swine disease caused by a variety of viruses, bacteria, and protozoa mixed infection caused by immunosuppressive swine diseases. There can be more than 15 kinds of pathogens, including swine fever virus, swine fever virus, circovirus, PRRS virus, pseudorabies virus, Eperythrozoon, toxoplasma, streptococcus, paratyphoid bacillus, mycoplasma, actinobacillus pleuropneumoniae, Haemophilus parasuis, Pasteurella, etc., or a mixed infection of these pathogens. Among them, the infection rate of classical swine fever virus is the highest and the most typical, and the mixed infection of toxoplasma, eperythrozoon, blue ear virus, circovirus, and classical swine fever virus is common. Symptoms of the disease are: coughing of pregnant sows...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/78A61K9/08A61P29/00A61P31/00A61P31/04A61P31/14A61K31/7076A61K31/7048A61K31/5383A61K31/167A61K31/133
Inventor 吴红云李建正郝志友董晓盈
Owner ZHENGZHOU HOUYI PHARMA
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