Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Sinomenine and luteolin composition and anti-angiogenic drug taking sinomenine and luteolin composition as active ingredient having synergistic action

A technology of luteolin and active ingredients, applied in the field of anti-angiogenesis drugs, can solve problems such as complex experimental procedures, huge combination space, and high cost

Inactive Publication Date: 2010-06-23
TSINGHUA UNIV
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the current field of drug research and development, the method of measuring the strength of synergy between drugs is mainly done through in vivo and in vitro experimental research. Due to the huge combination space, the experimental process is complicated and the cost is high.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Sinomenine and luteolin composition and anti-angiogenic drug taking sinomenine and luteolin composition as active ingredient having synergistic action
  • Sinomenine and luteolin composition and anti-angiogenic drug taking sinomenine and luteolin composition as active ingredient having synergistic action
  • Sinomenine and luteolin composition and anti-angiogenic drug taking sinomenine and luteolin composition as active ingredient having synergistic action

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] The inventors used the NIMS method to screen anti-angiogenesis drug combinations. There are 63 candidate drugs, and 63 candidate drugs form 63*(63-1) / 2=1953 drug combinations. The implementation effect is as follows:

[0065] The 63 drug candidates included two drug combinations known to have anti-angiogenic interactions: 5-fluorouracil+vinblastine, and 5-fluorouracil+rapamycin. Predicted by NIMS method, among all 1953 combinations, these two drug combinations known to have synergistic effects are all in the top three (see Table 1), and the results of the three gene networks are basically consistent. This example demonstrates the effectiveness of the NIMS method, which is capable of well finding drug combinations known to have synergistic effects.

[0066] Table 1. NIMS predictive ranking of known synergistic drug combinations among 1953 drug combinations

[0067]

[0068] Cell proliferation assay validation of NIMS method results

[0069] Taking sinomenine as an ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to an anti-angiogenic drug, a composition and an application of the composition as the active ingredient of the anti-angiogenic drug. The composition consists of sinomenine and luteolin. The drug is selected with a method for determining the synergistic action of medical composition based on biologic network (non-invasive microsphere NIMS method). Cell proliferation experimental detection proves that the composition really has active drug synergistic action.

Description

technical field [0001] The present invention relates to an anti-angiogenesis drug, a composition, and the application of the composition as an active ingredient of an anti-angiogenesis drug. The composition consists of sinomenine and luteolin. Background technique [0002] The development of drug combinations with synergistic effects is a new way to treat many diseases at present; the so-called synergistic effect (Synergistic effect) means that the effect of two drugs in combination is greater than the sum of the effects of the two drugs alone at the same dose. In the applicant's Chinese patent application No. 200610114226.X (authorized), a combination of pharmaceutical ingredients with synergistic effects is described, which is hereby cited in its entirety. However, in the current field of drug research and development, the method of measuring the synergy between drugs is mainly done through in vivo and in vitro experimental research. Due to the huge combination space, the...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/485A61K31/352A61P35/00
Inventor 李梢张宁波张博
Owner TSINGHUA UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com