Process for predicting the prognosis of squamous cell lung cancer

A technique for squamous cell and lung cancer, applied in the field of prediction of squamous cell lung cancer

Inactive Publication Date: 2010-11-03
VERIDEX LCC
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Despite potentially curative surgery, about 40% of patients relapse within 5 years

Method used

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  • Process for predicting the prognosis of squamous cell lung cancer
  • Process for predicting the prognosis of squamous cell lung cancer
  • Process for predicting the prognosis of squamous cell lung cancer

Examples

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Embodiment Construction

[0013] definition

[0014] The phrase "altered regulation" refers to an alteration in the abundance of a cellular component (eg, miRNA) relative to the abundance of the same cellular component in wild-type cells. The phrase "down-regulation" refers to a decrease in the abundance of the cellular component in question, whereas the phrase "up-regulation" refers to an increase in the abundance of the component.

[0015] Distinguishing squamous cell lung cancers based on differential miRNA regulation

[0016] Squamous cell lung cancer tissues were compared with wild-type tissues and fifteen differentially expressed miRNAs were identified (Table 1). Tissue samples include both cell lines and clinical samples. Total RNA was extracted from cell samples according to conventional techniques. For example, the mirVana Isolation Kit (Ambion) can be used for quick-frozen samples and the RecoverAll TM The Total Nucleic Acid Isolation Kit was used for formalin-fixed paraffin-embedded ...

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Abstract

Disclosed in this specification is a method for predicting the prognosis of squamous cell lung cancer by observing regulatory changes in select miRNA sequences. These sequences may include hsa-mir-146b, hsa-mir-191, hsa-mir-206, hsa-mir-299-3p, hsa-mir-155, hsa-mir-15a, hsa-mir-122a, hsa-mir-513, hsa-mir-184, hsa-mir-511, hsa- mir-100, hsa-mir-10a, hsa-mir-453, hsa-mir-379, hsa-mir-202, hsa-mir-21, hsa-mir-126, hsa-mir-494, hsa-mir-432, hsa-mir-370, and combinations of these sequences.

Description

[0001] Cross references to related patent applications [0002] This patent application claims priority and the benefit of co-pending US Provisional Patent Application Serial No. 60 / 983,756, filed October 30, 2007, which is hereby incorporated by reference in its entirety. [0003] References to Sequence Listings, Tables or Procedure Sheets [0004] This patent application refers to the "Sequence Listing" listed below, which is provided as an electronic file named "Sequence listing.txt" (6kb, created October 29, 2008), which is incorporated by reference in its entirety Incorporated into this article. technical field [0005] In one embodiment, the present invention relates to a method of providing a prognosis for squamous cell lung cancer by observing regulatory changes produced by selected microRNA (miRNA) sequences. By observing the upregulation or downregulation of specific sequences, both the presence of cancer cells and the prognosis of cancer can be determined. Ba...

Claims

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Application Information

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IPC IPC(8): C12Q1/68
CPCC12Q2600/178C12Q1/6886C12Q2600/118C12Q1/6851
Inventor M·拉波尼L·E·多西
Owner VERIDEX LCC
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