Process for predicting the prognosis of squamous cell lung cancer

Abstract

Disclosed in this specification is a method for predicting the prognosis of squamous cell lung cancer by observing regulatory changes in select miRNA sequences. These sequences may include hsa-mir-146b, hsa-mir-191, hsa-mir-206, hsa-mir-299-3p, hsa-mir-155, hsa-mir-15a, hsa-mir-122a, hsa-mir-513, hsa-mir-184, hsa-mir-511, hsa- mir-100, hsa-mir-10a, hsa-mir-453, hsa-mir-379, hsa-mir-202, hsa-mir-21, hsa-mir-126, hsa-mir-494, hsa-mir-432, hsa-mir-370, and combinations of these sequences.

Description

[0001] Cross references to related patent applications

[0002] This patent application claims priority and the benefit of co-pending US Provisional Patent Application Serial No. 60 / 983,756, filed October 30, 2007, which is hereby incorporated by reference in its entirety.

[0003] References to Sequence Listings, Tables or Procedure Sheets

[0004] This patent application refers to the "Sequence Listing" listed below, which is provided as an electronic file named "Sequence listing.txt" (6kb, created October 29, 2008), which is incorporated by reference in its entirety Incorporated into this article. technical field

[0005] In one embodiment, the present invention relates to a method of providing a prognosis for squamous cell lung cancer by observing regulatory changes produced by selected microRNA (miRNA) sequences. By observing the upregulation or downregulation of specific sequences, both the presence of cancer cells and the prognosis of cancer can be determined. Ba...

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