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Pharmaceutical composition for cancer treatment

A technology of composition and medicine, which is applied in the field of medicine to achieve the effect of convenient use, simple preparation method and good effect

Inactive Publication Date: 2010-12-22
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is no report that Avastin and chloroquine form a pharmaceutical composition for the treatment of cancer

Method used

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  • Pharmaceutical composition for cancer treatment
  • Pharmaceutical composition for cancer treatment
  • Pharmaceutical composition for cancer treatment

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1. preparation pharmaceutical composition of the present invention

[0019] Avastin (Roche company, batch number S20100023), is mixed with the Avastin solution of certain concentration with normal saline;

[0020] Chloroquine (SIGMA company. Batch number C6628-25G), is mixed with the chloroquine solution of certain concentration with normal saline;

[0021] According to the body weight, the dose of Avastin 7.6mg / kg+chloroquine 60mg / kg is mixed with Avastin solution and chloroquine solution before use.

[0022] Animal experiment

[0023] Experiment 1. The curative effect observation experiment of the pharmaceutical composition of the present invention on mouse melanoma

[0024] 60 C57 mice, provided by the Animal Experiment Center of the Second Military Medical University (the same below), male, with an average body weight of 20g, were randomly divided into six groups, 10 mice in each group, and were routinely inoculated with mouse melanoma cells B16 in the ...

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PUM

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Abstract

The invention relates to the field of medical technology, in particular to a pharmaceutical composition for cancer treatment, which consists of anti-angiogenesis drug Avastin and autophagy inhibitor chloroquine. When in use, Avastin and chloroquine are mixed according to respective dose, wherein the doses of Avastin and chloroquine are respectively 7.6mg / kg and 60mg / kg calculated according to weight. Animal experimental results show that the pharmaceutical composition can obviously inhibit the growth of skin cancer and liver cancer cells in mice, and the effect of inhabiting tumors is obviously higher than that of solely using Avastin or chloroquine, thus illustrating that the Avastin and the chloroquine have the function of synergistic inhibition on tumor growth, therefore, the pharmaceutical composition can be used for treating tumors.

Description

technical field [0001] The invention relates to the technical field of medicine, and is a pharmaceutical composition for treating cancer. Background technique [0002] Malignant tumor is the number one killer of human life and health. Tumors require a functional vascular network to provide oxygen, nourishment and remove metabolites. In addition to obtaining some blood vessels through fusion with host blood vessels, tumors must also build their own blood vessel system by forming a new blood vessel network, so that they can continue to grow and develop. Solid tumors do not grow more than 1mm without the vasculature to provide oxygen and nutrients 3 . In view of its important role in the occurrence and development of tumors, tumor blood vessels have become an important target for anti-tumor therapy. [0003] Vascular endothelial growth factor (VEGF) can directly act on vascular endothelial cells and stimulate them to undergo mitosis. Overexpression of VEGF has been confirm...

Claims

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Application Information

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IPC IPC(8): A61K39/395A61P35/00A61K31/4706
Inventor 卫立辛郭献灵李丁宋建瑞吴孟超
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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