Rumex gmelinii extract and application of effective part of rumex gmelinii to preparing antitumor medicament

An anti-tumor drug, a technology of Rumex vulgaris, which is applied in the directions of anti-tumor drugs, medical preparations containing active ingredients, and drug combinations, and can solve problems such as no therapeutic activity.

Inactive Publication Date: 2011-01-26
王振月
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no pharmacological study on the therapeutic activity of Rumex pilaris extract and its effective parts related to malignant tumors in the literature

Method used

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  • Rumex gmelinii extract and application of effective part of rumex gmelinii to preparing antitumor medicament
  • Rumex gmelinii extract and application of effective part of rumex gmelinii to preparing antitumor medicament
  • Rumex gmelinii extract and application of effective part of rumex gmelinii to preparing antitumor medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0155] Crush the root of Rumex trichomes through a 10-mesh sieve, accurately weigh 500 mg of medicinal material powder, add 70 ml of 50% ethanol to a Soxhlet extractor for extraction for 4 hours, filter the extract after cooling, and evaporate to dryness at 50-60 ° C under normal pressure; Obtained dry cream 210mg.

Embodiment 2

[0157] Take 50 g of dried roots of Rumex pilaris, crush them, add 8 times the amount of 50% ethanol, heat reflux extraction twice, each time for 4 hours, suction filter while hot, and combine the filtrates. Evaporate to dryness on a 60°C water bath to obtain 24 g of powder.

Embodiment 3

[0159] Take 500g of dry root powder of Rumex pilosula, add 8 times the amount of 75% ethanol, heat and reflux for extraction for 3 times, respectively for 2h, 2h, and 1h, suction filter while hot, and combine the filtrates. Evaporate to dryness on a water bath at 60°C, pass through AB-8 macroporous resin, collect water-eluted parts and dry under reduced pressure to obtain 32 g of dry paste. Its polysaccharide content is more than 60%.

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Abstract

The invention relates to a rumex gmelinii extract and application of an effective part of rumex gmelinii to preparing an antitumor medicament, determining a separation and enrichment process of the effective part of the rumex gmelinii. The animal transplanted tumor model and human tumor cell screening in vitro are used as screening means to research the extract of the rumex gmelinii and toluylene parts and amylase parts in the rumex gmelini, so that the invention proves that the rumex gmelinii extract can remarkably inhibit the growth of mouse transplanted tumors of S180, H22 and U14 and the growth of the human tumor cells of HepG-2, MCF-7, A549 and the like.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine. It specifically relates to the application of Rumex pilaris extract and its effective parts in the preparation of antitumor drugs. Background technique [0002] Malignant tumor is a major disease that endangers human health. According to WHO statistics, among the more than 5 billion people in the world, 6.9 million people die from malignant tumors every year on average, and 8.7 million new cases occur, and the number is still increasing year by year. It has become the second leading cause of death among various diseases after cardiovascular disease. Although great progress has been made in the treatment of malignant tumors, there is still a lack of ideal therapeutic drugs to meet clinical needs. Therefore, malignant tumors are regarded as refractory diseases, and scientists are still looking for safe and effective anti-tumor drugs. [0003] Rumex gmelini Turcz.ex Ledeb. is ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/70A61P35/00A61K125/00
Inventor 王振月侯素云王谦博唐先明高宁陈智岩
Owner 王振月
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