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Extract from oil palm leaves comprising phenolic acids

A palm tree and extract technology, applied in the field of oil palm tree leaf extract, can solve problems such as insufficient research or disclosure, insufficient antioxidant system, overloaded antioxidant system, etc.

Inactive Publication Date: 2011-07-13
NOVARTIS AG
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0018] 1. Overloading of the antioxidant system due to the production of a reactive oxygen metabolite; and / or
[0019] 2. Insufficient antioxidant system
[0044] In summary, the polyphenol-rich fractions of oil palm leaf extracts have been previously disclosed as antihypercholesterolemic and antihypertensive agents, but not studied Constituents containing (-)-catechin gallate, ferulic acid, and phenolic acids such as gallic acid and protocatechuic acid extracted from oil palm tree leaves have not been studied or disclosed. Use of an extract as an anti-oxidative stress preparation

Method used

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  • Extract from oil palm leaves comprising phenolic acids
  • Extract from oil palm leaves comprising phenolic acids
  • Extract from oil palm leaves comprising phenolic acids

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Embodiment Construction

[0064] The present invention relates to a composition comprising an extract of oil palm tree leaves, characterized in that said extract comprises (-)-catechin gallate, ferulic acid and phenolic acids such as gallic acid and protocatechin .

[0065] The oil palm tree leaves of the present invention include leaves of plants selected from the plant genus Oil palm including African oil palm or American oil palm.

[0066] The novel composition of the present invention comprises about 0.1% to about 95% by weight of (-)-catechin gallate, about 0.1% to about 95% by weight of ferulic acid and about 0.1% by weight to approximately 95% total phenolic acids such as gallic acid and protocatechuic acid.

[0067] In a preferred embodiment of the present invention, the composition comprises about 0.5% to about 10% by weight of (-)-catechin gallate, about 1% to about 5% of ferulic acid Acids and total phenolic acids such as gallic acid and protocatechuic acid in an amount of about 5% to abou...

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Abstract

Provided is a composition comprising an extract from oil palm leaves characterized in that the extract comprises (-)-catechin gallate, ferulic acid, and phenolic acids such as gallic acid and protocatechuic acid and a method for producing said extract comprising the steps of (a) extracting the dried or fresh oil palm leaves with a solvent, (b) filtering the extract obtained in (a), (c) contacting the filtered extract from (b) with an chromatographic medium which selectively adsorbs a fraction containing (-)-catechin gallate, ferulic acid, and phenolic acids, (d)eluting the said fraction from the chromatographic medium using a solvent, (e) drying the eluted fraction obtained in step (d). Also claimed is the use of the composition for reducing or preventing oxidative stress in mammals and poultry.

Description

technical field [0001] The present invention relates to oil palm tree leaf extracts having a therapeutic effect to reduce or avoid oxidative stress in humans and lower animals. In particular, the present invention relates to fractions of extracts rich in (-)-catechin gallate, ferulic acid and phenolic acids, such as gallic acid and protocatechin, which have the therapeutic effect. Background technique [0002] Oil palms (Elaeis) include two species of the palm family (Arecaceae), or palm family. The African oil palm (Elaeis guineensis) is native to West Africa, and the American oil palm (Elaeis oleifera) is native to tropical regions of Central and South America. The African oil palm tree is also widely grown in Malaysia and Indonesia for its oil-producing fruits. [0003] Mature oil palms are single-stemmed plants up to 20 meters tall, with pinnate leaves that can reach a length of 3 to 5 meters. A young tree produces about 30 leaves a year. The flowers of the oil palm...

Claims

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Application Information

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IPC IPC(8): A61K36/889A61P39/06A61P9/10A61K127/00
CPCA61K36/889A61P1/16A61P9/00A61P9/10A61P13/12A61P17/16A61P19/02A61P21/00A61P25/16A61P25/28A61P27/02A61P27/12A61P29/00A61P35/00A61P39/06A61P43/00
Inventor 彭宜零穆罕默德·法鲁斯·优思明·阿卜杜勒哈立德林彩君西蒂阿斯玛·汉巴里沙尔哈尔弗萨·谢里夫桑基莎·瑟拉斯南
Owner NOVARTIS AG
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