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System and method for characteristic parameter estimation of gastric impedance spectra in humans

A technology of characteristic parameters and impedance spectroscopy, used in applications, medical science, diagnosis, etc., can solve problems such as charge accumulation and current inability to flow through cells

Active Publication Date: 2012-01-04
CRITICAL PERFUSION
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] At low frequencies (below about 1 kHz), current may not be able to flow through the cell due to the capacitance of the cell membrane, resulting in charge accumulation at large membrane interfaces

Method used

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  • System and method for characteristic parameter estimation of gastric impedance spectra in humans
  • System and method for characteristic parameter estimation of gastric impedance spectra in humans
  • System and method for characteristic parameter estimation of gastric impedance spectra in humans

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Embodiment Construction

[0027] While preferred embodiments of the present invention have been shown and described herein, it will be obvious to those skilled in the art that these embodiments are provided by way of example only. Numerous variations, changes, and substitutions will readily occur to those skilled in the art without departing from the invention. It should be understood that various alternatives to the embodiments of the invention described herein may be employed in practicing the invention.

[0028] The present invention relates to systems and methods for characteristic parameter evaluation of gastric impedance spectroscopy. The systems and methods may use algorithms to obtain characteristic parameters from measured gastric impedance spectra. A monitoring device may be used to facilitate measurement of gastric impedance spectroscopy or other electrical or physiological parameters from a subject. The algorithm can transform the measured data, thus simplifying the data obtained and maki...

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Abstract

Impedance spectroscopy has been proposed as a method of monitoring mucosal injury due to hypoperfusion and ischemia In the critically ill The invention Includes an algorithm developed to calculate the characteristic electrical values best describing human gastnc impedance measurements A database of gastnc spectra was obtained from healthy volunteers, cardiovascular surgery and critically ill patients The gastnc spectrum forms two semi circles in the complex domain, divided into low frequency (F < 10kHz) and high frequency (F >1OkHz) A fitting algopthm was developed based on the Cole model, and central charactepstic parameters were calculated The parameters were validated using the normalized mean squared error and 0 7 % of the spectra were discarded From the expepmental data obtained in humans, the greatest changes observed as the gastnc mucosa becomes ischemic occur at low frequencies, which are specific and sensitive to tissue damage, and vary with the degree of hypoperfusion.

Description

[0001] cross reference [0002] This application claims priority to US Provisional Application No. 61 / 160409, filed March 16, 2009, which is hereby incorporated by reference in its entirety. Background technique [0003] Certain medical conditions can be monitored by measuring the impedance of tissue in a mammalian patient. This can be done by bringing electrodes into contact with the tissue, through which a low current can flow through the tissue. This technique is known for diagnostic and therapeutic applications. For example, electrical impedance spectroscopy (EIS) has been used for cytometry, volume change assessment, body composition analysis, tissue classification, and tissue monitoring. Impedance measurements can be used to detect cellular edema and other events related to the metabolism of tissue cells. [0004] Electrical impedance spectroscopy measures electrical impedance spectroscopy of superficial tissue by contacting a conductive probe with a tissue sample. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/053
CPCA61B5/4255A61B5/42A61B5/4238A61B5/053
Inventor N·E·贝尔特兰J·J·M·德弗尔特M·M·古迪尼兹E·萨克里斯添
Owner CRITICAL PERFUSION
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