Application of salinomycin and derivatives thereof in preparing drugs for preventing or treating brain glioma

A technology for brain glioma and its derivatives, which is applied in the direction of drug combinations, antineoplastic drugs, and active ingredients of heterocyclic compounds, and can solve the problems of lack of specific killing of glioma stem cells and the 2-year survival rate of patients is less than 30%. , to achieve strong selective killing of glioma stem cells, good medicinal prospects, and strong pharmacological effects

Inactive Publication Date: 2012-03-28
SOUTHWEST HOSPITAL OF CHONGQING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although a series of advances have been made in the field of comprehensive treatment of malignant glioma in the past 10 years, the 2-year survival rate of patients is still less than 30%.
[0018] 2. At present, there is still a lack of drugs that can specifically kill glioma stem cells
[0020] Salinomycin (salinomycin) is a monocarboxylic acid polyether animal-specific antibiotic (the structure is as follows). It is currently used as an anti-coccidial agent for chickens and a growth promoter for piglets and fattening pigs. There is no precedent for its application in the treatment of glioma Or reports that can prove its effectiveness and feasibility

Method used

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  • Application of salinomycin and derivatives thereof in preparing drugs for preventing or treating brain glioma
  • Application of salinomycin and derivatives thereof in preparing drugs for preventing or treating brain glioma
  • Application of salinomycin and derivatives thereof in preparing drugs for preventing or treating brain glioma

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0033] In order to better understand the essence of the present invention, the drug efficacy test and results of salinomycin will be used to illustrate its new use in the field of pharmacy.

[0034] 1. Experimental materials

[0035] (1) cell line

[0036] The mouse glioma cell line GL261 was donated by Professor Bian Xiuwu of the Institute of Pathology, Southwest Hospital, Third Military Medical University (also available for purchase), and purchased from the American type culture collection (ATCC)

[0037] (2) Experimental animals

[0038] Six-week-old male C57BL / 6 mice of SPF grade, weighing (22±2) g, were purchased and raised in the Animal Experiment Center of Third Military Medical University.

[0039] (3) Main reagents and antibodies

[0040]

[0041]

[0042] (4) Main instruments and equipment

[0043]

[0044]

[0045] (5) Preparation of main reagents

[0046] 1. DMEM / F12 basal medium: Dissolve DMEM / F12 bagged powder in 900ml triple-distilled water, st...

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Abstract

The invention provides the application of salinomycin and derivatives thereof in preparing drugs for preventing or treating brain glioma, relates to the new pharmaceutical use of known salinomycin and derivatives thereof and develops a new application area. The salinomycin and derivatives thereof show strong pharmacological actions, have a strong effect of selectively killing brain glioma stem cells, and have good pharmaceutical prospects.

Description

technical field [0001] The present invention relates to the application of salinomycin and its derivatives in the preparation of drugs for preventing or treating brain tumors, more specifically, the application of drugs for preventing or treating brain gliomas. Background technique [0002] Malignant tumors are major diseases that endanger human health, and the global cancer situation will become increasingly serious. In the next 20 years, the number of new patients will increase from the current 10 million per year to 15 million, and the number of deaths from cancer will also increase from 6 million to 10 million per year. According to the statistics of the Ministry of Health, the incidence of malignant tumors in my country is 130.3-305.4 / 100,000 for men and 39.5-248.7 / 100,000 for women. In recent years, there are 1.6 to 1.7 million new cancer patients in my country every year, and the total number is estimated to be about 4.5 million. The mortality rate of malignant tumo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/35A61P35/00
Inventor 陈图南冯华李飞叶雷钱忠明
Owner SOUTHWEST HOSPITAL OF CHONGQING
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