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Cdc45l peptides and vaccines including the same

A HLA-A24, antigen technology, applied in the field of drugs for the treatment and prevention of tumors, can solve the problem that the usefulness of CDC45L has not been fully investigated

Active Publication Date: 2012-05-16
ONCOTHERAPY SCI INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the usefulness of CDC45L as a target for cancer immunotherapy has not been fully investigated

Method used

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  • Cdc45l peptides and vaccines including the same
  • Cdc45l peptides and vaccines including the same
  • Cdc45l peptides and vaccines including the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0385] Materials and methods

[0386] cDNA microarray analysis

[0387] Gene expression profiles were generated using cDNA microarray analysis as previously described (Nakamura T et al., Oncogene 2004; 23:2385-400, Taniwaki M et al., Int J Oncol 2006; 29:567-75). Raw data for microarray analysis are available upon request from Prof. Y. Nakamura (The University of Tokyo, Graduate School of Medicine). Tissue samples from lung cancer and adjacent noncancerous normal lung tissue were obtained from surgical specimens, and all patients provided informed consent to participate in the study.

[0388] mouse

[0389] Six-week-old female non-obese diabetic (NOD) / severe combined immunodeficiency (SCID) mice were purchased from Charles River Laboratories Japan. The mice were bred at the Animal Resources and Development Center of Kumamoto University, and their operation complied with the animal care guidelines of Kumamoto University.

[0390] Cell lines and HLA expression

[0391] CD...

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Abstract

The present invention provides isolated peptides or the fragments derived from SEQ ID NO: 18, which bind to an HLA antigen and induce cytotoxic T lymphocytes (CTL). The peptides may include one of the above mentioned amino acid sequences with substitution, deletion, or addition of one, two, or several amino acids sequences. The present invention also provides pharmaceutical compositions including these peptides. The peptides of the present invention can be used for treating cancer.

Description

technical field [0001] priority [0002] This application claims the benefit of US Provisional Application No. 61 / 217,133, filed May 26, 2009, the entire contents of which are hereby incorporated by reference. [0003] The present invention relates to the field of biological sciences, more specifically to the field of cancer treatment. Specifically, the present invention relates to novel peptides that are extremely effective as cancer vaccines, and drugs for treating and preventing tumors. Background technique [0004] Lung cancer is the most common form of cancer, accounting for 1.35 million of the 10.9 million new cases of cancer each year. It is also the leading cause of death from cancer-related diseases, accounting for 1.18 million of the 6.7 million cancer-related deaths worldwide (NPL 1). Despite recent improvements in systemic therapies such as chemotherapy and molecularly targeted therapies, the prognosis of patients with advanced lung cancer remains poor (NPL 2...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/09A61K39/00A61P35/00C07K14/47C07K16/18C12N5/078C12N5/0783C12N5/10
CPCA61K39/0011A61K2039/5158C07K14/4748A61P35/00A61K39/4644A61K39/4611A61K2239/38A61K2239/55A61K39/46432A61K2239/31A61K39/464838C07K16/28A61K39/395C07K16/24A61K38/19C07K16/30C07K14/475C07K14/54A61K38/18
Inventor 西村泰治富田雄介中村佑辅角田卓也
Owner ONCOTHERAPY SCI INC
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