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Application of thioredoxin to preparing medicament for curing pyemia and preventing multiple-organ dysfunction syndrome (MODS) caused by pyemia

A technology of thioredoxin and MODS, which is applied in the field of treating or preventing MODS caused by sepsis, and achieves the effects of good bioavailability, reduced respiration rate, and small molecular weight

Inactive Publication Date: 2012-07-11
陶凌
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, whether rhTrx can be used to treat MODS in animals has been rarely reported at home and abroad.

Method used

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  • Application of thioredoxin to preparing medicament for curing pyemia and preventing multiple-organ dysfunction syndrome (MODS) caused by pyemia
  • Application of thioredoxin to preparing medicament for curing pyemia and preventing multiple-organ dysfunction syndrome (MODS) caused by pyemia
  • Application of thioredoxin to preparing medicament for curing pyemia and preventing multiple-organ dysfunction syndrome (MODS) caused by pyemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0047] 1. Establish animal MODS model and research protocol

[0048] Adult miniature piglets were treated with lipopolysaccharide (LPS, 2.0 mg / kg), the damage of multiple organs of the body was detected, and the survival time of the animals was observed. Among them, the bedside monitor was used to monitor the vital signs of the animals throughout the whole process after LPS treatment, and 1, 2, 4, and 6 hours after LPS, three items of heart damage, seven items of liver function, two items of kidney function, blood routine, etc. were detected. For serological indicators, 12ml of blood was drawn each time, and X-ray plain films were taken to observe lung damage at 6 hours.

[0049] 1) Establishment of porcine MODS model and Trx treatment: Male miniature pigs with a body weight of 15 to 20 kg were divided into random groups, with 6-8 animals in each group. The animals were fasted for 12 hours, had free access to water, and were sedated by intramuscular injection of pentobarbital...

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Abstract

The invention discloses application of human-derived small-molecule antioxidant anti-inflammatory thioredoxin (Trx) to preparing a medicament for curing pyemia and preventing a multiple-organ dysfunction syndrome (MODS) caused by the pyemia. The Trx can remarkably relieve pyemia syndromes, protect organs of animals suffering from pyemia diseases and prevent the MODS including preventing respiratory distress, reducing heart damage, lung damage, liver damage and kidney damage, and the like. When an infection source possibly causing the pyemia enters animal bodies, the Trx is injected into the animal bodies, so that the MODS is avoided, and the survival rate of the animals is increased.

Description

technical field [0001] The present invention relates to the field of application of small molecular protein drugs to treat diseases, more specifically, relates to the application and mechanism of human thioredoxin in treating or preventing MODS caused by sepsis by playing an organ protection function. Background technique [0002] Sepsis is a common and fatal disease, the essence of which is a malignantly enlarged inflammatory response. Although the inflammatory response has been known for decades, its original definition has varied wildly. Until 1992, the American College of Chest physicians (ACCP) and the Society for Critical Care Medicine (SCCM) uniformly defined it as Systemic Inflammatory Response Syndrome (SIRS) ), and on this basis, sepsis, severe sepsis and septic shock are derived. With the further development of sepsis, it will often cause insufficiency of various organs of the body, resulting in multiple organ dysfunction syndrome (Multiple Organ Dysfunction Syn...

Claims

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Application Information

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IPC IPC(8): A61K38/44A61P7/00A61P29/00A61P43/00
Inventor 陶凌屈延许爱斌刘静祎
Owner 陶凌
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