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Preparation method of artemisinin slow-release body

An artemisinin, slow-release technology, applied in the fields of botanical equipment and methods, chemicals for biological control, animal repellents, etc., can solve the problem of high cost, cost reduction, and short effective time of artemisinin for algal inhibition. and other problems to achieve the effect of suppressing outbreaks, prolonging suppression time, and reducing costs

Inactive Publication Date: 2013-07-31
HOHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Technical problem to be solved: In order to overcome the short effective time and high cost of directly adding artemisinin to inhibit algae, the purpose of the present invention is to provide a kind of artemisinin slowing down Method for preparing algae-inhibiting dosage form by releasing body, prolonging the effective time of algae-inhibiting and reducing cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] Weigh 0.2g of artemisinin and dissolve it in 1.5mL of ethyl oleate, add 1mL of co-solvent absolute ethanol, then add 1mL of emulsifier OP-10, make a 50mL solution with distilled water, then add 0.3g of sodium alginate and mix well, Draw the above mixed solution with a syringe and drop it into 100mL glacial acetic acid solution containing 0.75g chitosan and 3g calcium chloride with a glacial acetic acid content of 3%vt to form microspheres, add 1.5mL glutaraldehyde after cooling to room temperature, Suction filtration, washing with petroleum ether and distilled water for 5-8 times; drying for 36h-72h to obtain artemisinin sustained-release body. Use artemisinin slow-release body to carry out acute toxicity experiment to aseptic culture Microcystis aeruginosa, set up three parallel groups, observe once every 24 hours, observe continuously for one week, when the artemisinin slow-release body weighed is 2g, its The 96h inhibition rate of Microcystis aeruginosa reached 75%. ...

Embodiment 2

[0010] Weigh 0.1g of artemisinin and dissolve it in 1mL of ethyl oleate, add 0.5mL of co-solvent absolute ethanol, then add 1mL of emulsifier OP-10, make a 50mL solution with distilled water, then add 0.6g of sodium alginate and mix well, Draw the above mixed solution with a syringe and drop it into 100mL of glacial acetic acid solution containing 0.5g of chitosan and 4g of calcium chloride with a glacial acetic acid content of 3%vt to form microspheres, add 2mL of glutaraldehyde after cooling to room temperature, and pump Filter, rinse with petroleum ether and distilled water for 5-8 times; dry for 36h-72h to obtain artemisinin sustained-release body. Use artemisinin slow-release body to carry out acute toxicity experiment to aseptic culture Microcystis aeruginosa, set up three parallel groups, observe once every 24 hours, observe continuously for one week, when the artemisinin slow-release body weighed is 2g, its The 96h inhibition rate of Microcystis aeruginosa reached 80%....

Embodiment 3

[0012] Weigh 0.3g of artemisinin and dissolve it in 2mL of ethyl oleate, add 1.5mL of co-solvent absolute ethanol, then add 1.5mL of emulsifier OP-10, make a 50mL solution with distilled water, then add 0.9g of sodium alginate and mix well , use a syringe to draw the above mixed solution and drop it into 100mL glacial acetic acid solution containing 0.25g chitosan and 4g calcium chloride with a glacial acetic acid content of 3% vt to form microspheres, add 1.5mL glutaraldehyde after cooling to room temperature , filtered with suction, washed 5-8 times with petroleum ether and distilled water; dried for 36h-72h to obtain artemisinin sustained-release body. Use artemisinin slow-release body to carry out acute toxicity experiment to aseptic culture Microcystis aeruginosa, set up three parallel groups, observe once every 24 hours, observe continuously for one week, when the artemisinin slow-release body weighed is 2g, its The 96h inhibition rate of Microcystis aeruginosa reached 8...

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Abstract

A preparation method of an artemisinin slow-release body comprises the following steps, using ethyl oleate to dissolve artemisinin, adding a cosolvent, then adding an emulsifier, and adding the emulsified artemisinin into solution of sodium alginate; dripping the solution into glacial acetic acid solution containing chitosan and calcium chloride to form microspheres; in a system, enabling volume percentage of glacial acetic acid to be 2%-5%, and enabling mass content of chitosan and mass content of calcium chloride to be 0.25%-1.5% and 1%-4% respectively; after cooling to the room temperature, adding a cross-linking agent which is glutaraldehyde or glyceraldehyde, enabling the dosage of the cross-linking agent to be 1%-4% of the mass of the reaction system; perform suction filtration, andusing petroleum ether and distilled water to wash for 5-8 times; and obtaining the artemisinin slow-release body after drying for 36h-72h, and enabling the drying temperature not to be higher than 45DEG C. The preparation method of the artemisinin slow-release body can effectively prolong the restraining time of blue algae through the artemisinin in a water body, reduces cost, can be applied to natural water bodies including pools, reservoirs, lakes and the like, and refrains algal burst.

Description

technical field [0001] The invention belongs to the field of water body eutrophication control, and relates to a preparation method of an artemisinin slow-release body, in particular to a slow-release body made of an algae-inhibiting substance artemisinin and applied to the field of algae suppression in real water bodies. It provides a new technical approach to inhibit algae in natural water bodies. Background technique [0002] Microcapsule technology is a kind of micro-packaging technology, which is a method of covering dispersed solid, liquid or gas with natural or synthetic polymer film-forming materials to form tiny particles. The preparation technology of microcapsules began in the 1930s and developed rapidly in the mid-1970s. Microcapsules have broad application prospects in the field of drug controlled release because of their excellent controlled release properties such as long-acting, high-efficiency, targeting, and low side effects; It has become a research hots...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N43/90A01N25/04A01P13/00
Inventor 倪利晓任高翔于东盛胡淑珍储祥林李勇朱亮
Owner HOHAI UNIV
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