'Zn red benzoyl peroxide' gelation for treating acne vulgaris and preparation method thereof

A technology of zinc red benzoyl peroxide and benzoyl peroxide, applied in the field of preparation of the medicine, can solve the problems of high price and the like, and achieve the effects of being beneficial to storage, less adverse reaction and significant curative effect

Active Publication Date: 2013-06-05
杨光明 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing first-generation benzoyl peroxide "Bansai" from France and the second-generation benzoyl peroxide "Bimison" from the United States are available for treatment. "Bansai" was first developed by the French in the 1950s A gel containing 5% benzoyl peroxide, the preparation is currently entrusted by Galderma Pharmaceuticals of France to Shanghai Bairun Pharmaceutical Technology Co., Ltd. for patent production, and its production technology and raw materials are all provided by the French; and "must" "Maison" is the last century. On February 25, 1995, the Americans filed a patent application with the China Medical Administration. Its main ingredients contain 5% benzoyl peroxide and 3% erythromycin. Benzoyl peroxide "Bansai" gel was successfully added with erythromycin, and after "Bimeson" gel was put into the domestic market, the academic circle of skin cosmetology believed that it was a great development in the history of acne vulgaris treatment, but there was a fly in the ointment Unfortunately, due to its high price, and 33% to 38% of local adverse reactions occurred, especially in dry skin or cold and dry seasons, some patients stopped the drug because of intolerance, thus limiting the wide clinical application

Method used

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  • 'Zn red benzoyl peroxide' gelation for treating acne vulgaris and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] According to 100 grams of preparation, weigh the net material as follows:

[0036] Sodium Carboxymethyl Cellulose 2g Zinc Sulfate 2g 70% Benzoyl Peroxide 3.65g

[0037] Polyoxyethylene Lauryl Ether 6g Sodium Lauryl Sulfate 0.5g Erythromycin 3g

[0038] Glycerin 10ml Distilled water 65ml Propylene glycol 20ml

[0039] The preparation method is as follows:

[0040] ①Put 2g of sodium carboxymethylcellulose + 10ml of glycerin into a measuring cup, and stir clockwise until no drug particles;

[0041] ②Put 65ml of distilled water in another measuring cup, heat it to 38°C, pour it into the cup ① while stirring, and stir until it becomes translucent gel;

[0042] ③Take 2g of zinc sulfate and 3.6g of 70% benzoyl peroxide, grind the two into fine powder in turn, pass through a 100-mesh sieve, slowly pour into cup ①, and stir until uniform;

[0043] ④ Put 6g of polyoxyethylene lauryl ether + 5ml of propylene glycol into another cup, heat to 38°C, stir until dissolved, after co...

Embodiment 2

[0047] Weigh the raw materials and the steps are the same as in Example 1, and the temperature is heated to 42°C.

[0048]Method of use and effect: Dip a proper amount of ointment with a cotton swab or finger, and apply it on the affected area. For generalized acne, papules, pustules or nodular cysts, the application is not limited to the skin lesions, but the entire affected area of ​​acne All should be applied with medicine, 1-2 times a day, once in the morning and evening after washing the face for facial rash, 3-4 weeks is a course of treatment, and for some cases, two courses of treatment will be used to see the obvious effect. The pustular type has the best effect. In a few cases, apply the ointment once before going to bed, and it disappears the next morning. The papular acne disappears in 1-2 weeks, and the acne disappears in 3-4 weeks. It fades gradually within 8 weeks (this product needs to be stored in airtight and refrigerated storage).

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Abstract

The invention relates to a 'Zn red benzoyl peroxide' gelation for treating acne vulgaris and a preparation method thereof. A gelling agent is prepared from medicaments such as sodium cellulose glycolate, zinc sulfate, 70% benzoyl peroxide, polyoxyethylene dodecyl aether, erythromycin, glycerol, distilled water and propylene glycol. The gelation provided by the invention is uniform and refine, is not dry and liquified, and has good skin absorption, quick response, small adverse reaction, and good adaptation compliance for local external use, and is effective in treatment.

Description

technical field [0001] The invention relates to a "zinc red benzoyl peroxide" gel for treating acne vulgaris, and also relates to a preparation method of the medicine. Background technique [0002] Acne is a common and frequently-occurring disease among teenagers, and it also occurs in middle age. It not only affects the appearance, but also affects the health of the body. The existing first-generation benzoyl peroxide "Bansai" from France and the second-generation benzoyl peroxide "Bimison" from the United States are available for treatment. "Bansai" was first developed by the French in the 1950s A gel containing 5% benzoyl peroxide, the preparation is currently entrusted by Galderma Pharmaceuticals of France to Shanghai Bairun Pharmaceutical Technology Co., Ltd. for patent production, and its production technology and raw materials are all provided by the French; and "must" "Maison" is the last century. On February 25, 1995, the Americans filed a patent application with t...

Claims

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): A61K9/00A61K33/30A61K47/38A61P17/10A61K31/327A61K31/7048
Inventor杨光明谭拥军
Owner杨光明