In-situ gel sustained-release preparation of Ranunculus ternatus Thunb., and its preparation method

A technology of in-situ gel and sustained-release preparations, which is applied in the direction of pharmaceutical formulations, non-central analgesics, and medical preparations of non-active ingredients, which can solve problems that cannot meet clinical needs and achieve excellent erosion effects

Inactive Publication Date: 2012-07-25
INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, only "Cat's Claw Capsules" has been listed on the market, which is far from meeting the clinical needs.

Method used

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  • In-situ gel sustained-release preparation of Ranunculus ternatus Thunb., and its preparation method
  • In-situ gel sustained-release preparation of Ranunculus ternatus Thunb., and its preparation method
  • In-situ gel sustained-release preparation of Ranunculus ternatus Thunb., and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0147] The ethanol extract of Cat's Claw is: 50g of Cat's Claw is crushed, passed through a 80 mesh sieve, added 500ml of absolute ethanol, boiled for 1.5h, takes the filtrate, extracts twice in the same way, merges the filtrate three times, evaporates to dryness, and adds 200ml water, and ultrasonically disperse the extract evenly in water to make a milky yellow suspension, which is to obtain the aqueous solution of cat's claw ethanol extract.

[0148] Add 1% sodium alginate and 1% HPMC to the prepared aqueous solution of cat's claw ethanol extract; stir for 24 hours to fully swell the sodium alginate and HPMC. Add 1mol / L CaCl2 solution, every 10ml in situ gel needs to add 1ml CaCl 2 , made into a gel.

Embodiment 2

[0150] The in-situ gel preparation of the cat's claw powder: 20 mg of cat's claw powder (passed through a 100-mesh sieve, 0.15 mm); dispersed in 100 ml of deionized water.

[0151] Add cat's claw powder to an aqueous solution of 1% sodium alginate and 1% HPMC; stir for 24 hours to fully swell the sodium alginate and HPMC. Add 1mol / L CaCl2 solution, every 10ml in situ gel needs to add 1ml CaCl2 to make a gel.

Embodiment 3

[0153] Crush 50g of cat's claw, pass through a 80-mesh sieve, add 500ml of water, boil for 1.5h, take the filtrate, extract twice more in the same way, combine the three filtrates, concentrate to 200ml, and obtain the cat's claw aqueous solution.

[0154] Add 1% sodium alginate and 1% HPMC to the cat's claw water solution; stir for 24 hours to fully swell the sodium alginate and HPMC.

[0155] Add 1mol / L CaCl2 solution, every 10ml in situ gel needs to add 1ml CaCl 2 , made into a gel.

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PUM

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Abstract

The invention discloses an in-situ gel sustained-release preparation of Ranunculus ternatus Thunb. Its preparation method includes dispersing extract or crude powder of Ranunculus ternatus Thunb. as active component in aqueous solution. Adjuvant composition of the aqueous solution includes sodium alginate 0.1-3%, and hydroxypropyl methylcellulose 0.1-3%. The invention is favorable for pertinent intervention treatment of refractory, recurrent and multidrug-resistant tuberculosis, shortens cavity closure time, accelerates distal focus absorption, reduces recurrence and dissemination, and greatly improves curative rate of pulmonary tuberculosis.

Description

technical field [0001] The invention relates to an in-situ gel sustained-release preparation, in particular to an in-situ gel sustained-release preparation of the traditional Chinese medicine cat's claw and a preparation method thereof. Background technique [0002] The traditional Chinese medicine cat's claw grass is the dry tuber root of the Ranunculaceae plant (Ranuneulus ternatus Thunb.). Alias: Sansancao (Zhejiang), Cat's Claw (Henan), Cat's Claw (Henan), Jianiaojiao (Anhui), Golden Flower Grass (Guangxi). As a very useful herbal medicine, it has been found to have a good anti-tumor effect in recent years and has become a research hotspot. Cat's claw is warm in nature, sweet and pungent in taste, and has the effects of reducing swelling and dissipating stagnation, clearing away heat and detoxifying. It has the functions of anti-tuberculosis and other bacteria, anti-tumor, anti-inflammation, and improving the body's immunity. [0003] At present, only "Cat's Claw Caps...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61K47/38A61K9/06A61P31/06A61P31/04A61P35/00A61P29/00A61P37/04A61K125/00
Inventor 朱春燕胡春晖冯翰洲
Owner INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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