Method for detecting ethyl urethane content of cigarette sidestream smoke via LC-MS/MS combination

Abstract

The invention discloses a method for detecting ethyl urethane content of cigarette sidestream smoke via LC-MS / MS combination. A fishtail hood and a glass fiber filter disc are utilized to collect ethyl urethane of cigarette sidestream smoke; ethanol is applied to extraction of the glass fiber filter disc and cleaning of the fishtail hood; and an extraction liquid is diluted and then purified by a solid phase extraction small column, and finally eluted via dichloromethane, an eluant is detected by an efficient liquid chromatogram / tandom mass spectrometer, and the content of the ethyl carbamate of the cigarette side flow smoke. The method is simple and convenient to operate, has a good separation effect and accurate determination, and is short in sample analysis time and high in detection sensitivity.

Description

technical field

[0001] The invention belongs to the technical field of tobacco and chemistry, and in particular relates to a method for detecting the content of ethyl carbamate in cigarette sidestream smoke by using high-performance liquid chromatography-tandem mass spectrometry. Background technique

[0002] During the combustion process of cigarettes, various physical and chemical reactions such as distillation, dry distillation, pyrolysis, synthesis, and condensation have occurred, forming a large number of nascent compounds, and the composition of the smoke is very complex. Sidestream smoke is the smoke substance released directly from the cigarette burning cone into the air and diffused from the cigarette paper. Most of the sidestream smoke occurs during the smoldering process of the cigarette, and a small part is generated during the smoking process. , Therefore, the types of compounds in mainstream and sidestream smoke are basically the same, but the content is quite ...

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