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Medicament compound preparation formed by mixing olmesartan medoxomil with benzene sulfonic acid amlodipine and hydrochlorothiazide

A technology of olmesartan medoxomil and amlodipine, applied in the field of medicine, can solve the problems of large tablets, difficult to take large tablets and the like

Inactive Publication Date: 2012-12-26
ZHUHAI EBANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the large number of excipients present in In the formulation of the drug, the tablet is relatively large, and such a large tablet is generally difficult to take, especially in elderly patients

Method used

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  • Medicament compound preparation formed by mixing olmesartan medoxomil with benzene sulfonic acid amlodipine and hydrochlorothiazide
  • Medicament compound preparation formed by mixing olmesartan medoxomil with benzene sulfonic acid amlodipine and hydrochlorothiazide
  • Medicament compound preparation formed by mixing olmesartan medoxomil with benzene sulfonic acid amlodipine and hydrochlorothiazide

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0056] The present invention will be described in more detail in the following examples, but the scope of the present invention is not limited thereto.

[0057] Composition of each piece

[0058]

[0059]

[0060] The mixing of the above raw materials requires the following steps

[0061] Mix olmesartan medoxomil, amlodipine besylate and hydrochlorothiazide, silicified microcrystalline cellulose, and croscarmellose sodium with a mixer. The powders were mixed through a 1.9mm sieve. The sieved powder was mixed again with a mixer. Magnesium stearate was added and blended again to make the final blended ingredients. After mixing, use a shallow concave die to compress the tablet, and select the appropriate pressure and tablet weight. The film coating material is Opadry II dissolved in purified water, and the coating equipment is selected for spray coating.

[0062] Stability test

[0063] The tablets were placed in a HDPE bottle sealed with a desiccant for an accelerate...

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Abstract

The invention relates to a medicament compound preparation formed by mixing olmesartan medoxomil with benzene sulfonic acid amlodipine and hydrochlorothiazide. Both the olmesartan medoxomil and amlodipine are unstable compounds, and are difficultly prepared into mixed medicaments with stable active ingredients. According to the invention, the adjuvant of the olmesartan medoxomil and amlodipine compound preparation is regulated, so that the amounts of degradation products and impurities of the olmesartan medoxomil are effectively reduced. The invention provides a method for preparing the fixed-dose compound preparation which takes the olmesartan medoxomil, the amlodipine and hydrochlorothiazide as the active ingredients.

Description

technical field [0001] The invention relates to a compound preparation of olmesartan medoxomil, amlodipine besylate and hydrochlorothiazide, which solves the problem of adjusting the preparation auxiliary materials of the compound recipe of olmesartan medoxomil and amlodipine, and effectively reduces the degradation products of olmesartan medoxomil and the amount of impurities, which belong to the technical field of medicine. Background technique [0002] The mixture of olmesartan medoxomil and amlodipine has good curative effect in treating and preventing hypertension or hypertension caused by diseases. [0003] At present, more and more clinical data and escalating solid dosage requirements also prove the hypothesis of the combination of olmesartan medoxomil and amlodipine. However, both olmesartan medoxomil and amlodipine are chemical compounds, and it is difficult to make a stable mixed drug with active ingredients. Therefore, to realize this technology, it is necessar...

Claims

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Application Information

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IPC IPC(8): A61K31/549A61K31/4422A61P9/12A61P9/10A61P9/06A61P13/12A61K31/4178
Inventor 吴浩山李翱
Owner ZHUHAI EBANG PHARMA
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