Metronidazole mucilage and preparation method thereof

The technology of metronidazole glue and metronidazole is applied in the directions of pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc. Sensitivity and other problems, to achieve the effect of favorable treatment and rehabilitation protection, rapid onset time, comfortable subjective feeling

Active Publication Date: 2014-05-07
上海瑞圣生物医学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Metronidazole is a commonly used drug to treat vaginitis and senile vaginitis in menopausal women and patients after uterine and ovarian surgery. Its dosage forms include vaginal effervescent tablets and vaginal suppositories. Sensitive flaws
[0003] The basic principle of vaginal effervescent tablets is that the acid-base substances contained in the tablets undergo a neutralization reaction in the presence of moisture in the vaginal environment, and at the same time release carbon dioxide gas to form a drug-containing foam to disperse the drug. The vaginal suppository is in the process of melting from solid to liquid In addition to the temperature factor, moisture is also a necessary condition. For patients with insufficient vaginal fluid secretion, middle-aged and elderly women, and women with physiological innate and acquired insufficient secretion, the above dosage forms may affect drug dispersion due to insufficient environmental moisture, which is obviously inappropriate. , it is clinically hoped to replace it with other drugs that overcome the above-mentioned defects

Method used

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  • Metronidazole mucilage and preparation method thereof
  • Metronidazole mucilage and preparation method thereof
  • Metronidazole mucilage and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Dissolve 7.5g of metronidazole in 800ml of water and put it into a container; mix 40g of glycerol, 10g of propylene glycol, 10g of polyoxyethylene polyoxypropylene copolymer and 30g of polyethylene oxide 8000, and stir until the material dissolves into a colloid Solution state; in another container, dissolve 0.7g chlorhexidine acetate and 0.1g disodium EDTA with 200ml water and mix them into the above colloidal solution, stir well, adjust the pH to 6.0, place it for 12 hours and subpackage to obtain metronidazole Azole glue finished product.

Embodiment 2

[0022] Dissolve 75g of metronidazole with 8000ml of water and put it in a container; mix 300g of glycerol, 200g of propylene glycol, 100g of polyoxyethylene polyoxypropylene copolymer and 300g of polyethylene oxide 8000, and put it in a homogenizer to homogenize Dissolve the material into a colloidal solution; in another container, dissolve 7g of chlorhexidine acetate and 1g of disodium EDTA with 2000ml of water and mix them into the above-mentioned colloidal solution, stir well, adjust the pH to 7.0, place it for 10 hours, and then pack it separately. Get metronidazole mucilage.

Embodiment 3

[0024] Dissolve 1g of metronidazole with 800ml of water and put it in a container; mix 50g of glycerol, 100g of polyoxyethylene polyoxypropylene copolymer and 1g of polyethylene oxide 6000, and stir until the material dissolves into a colloidal solution; In another container, 10 g of chlorhexidine hydrochloride and 0.5 g of disodium EDTA were dissolved in 200 ml of water and mixed into the above-mentioned colloidal solution, adjusted to a pH of 6.5, fully stirred to obtain a metronidazole glue.

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Abstract

The invention discloses a metronidazole mucilage which is characterized by comprising the following components in parts by weight: 1000 parts of water, 1-10 parts of metronidazole, 10-300 parts of glycerol and / or propylene glycol, 0.1-10 parts of chlorhexidine, 1-100 parts of polyethylene oxide, 5-100 parts of polyoxyethylene polypropylene oxide copolymer and 0.05-0.5 parts of EDTA (Ethylene Diamine Tetraacetic Acid) disodium. The invention also discloses a preparation method of the metronidazole mucilage, comprising the steps of dissolving metronidazole by using water, adding other components, and fully and uniformly mixing to form a colloidal solution. The metronidazole mucilage disclosed by the invention has the due efficacy of metronidazole drugs and is capable of simulating cervix uteri, vagina mucus and moist local ecological environment of healthy women, suitable for the treatment and the rehabilitation protection of female reproductive tract infections, menopause vaginitis and reproductive tract infection after the uterus ovarian surgery and capable of overcoming the defect that the dispersion of traditional vaginal effervescent tablets, vaginal suppositories and lotions may be influenced due to insufficient environmental moisture.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, in particular to a metronidazole mucilage; in addition, the invention also relates to a preparation method of the metronidazole mucilage. Background technique [0002] Metronidazole is a commonly used drug to treat vaginitis and senile vaginitis in menopausal women and patients after uterine and ovarian surgery. Its dosage forms include vaginal effervescent tablets and vaginal suppositories. sense of flaws. [0003] The basic principle of vaginal effervescent tablets is that the acid-base substances contained in the tablets undergo a neutralization reaction in the presence of moisture in the vaginal environment, and at the same time release carbon dioxide gas to form a drug-containing foam to disperse the drug. The vaginal suppository is in the process of melting from solid to liquid In addition to the temperature factor, moisture is also a necessary condition. For patients with insufficient vagin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K31/4164A61K47/34A61P15/02
Inventor 王晓明
Owner 上海瑞圣生物医学科技有限公司
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