Metronidazole mucilage and preparation method thereof
The technology of metronidazole glue and metronidazole is applied in the directions of pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc. Sensitivity and other problems, to achieve the effect of favorable treatment and rehabilitation protection, rapid onset time, comfortable subjective feeling
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Embodiment 1
[0020] Dissolve 7.5g of metronidazole in 800ml of water and put it into a container; mix 40g of glycerol, 10g of propylene glycol, 10g of polyoxyethylene polyoxypropylene copolymer and 30g of polyethylene oxide 8000, and stir until the material dissolves into a colloid Solution state; in another container, dissolve 0.7g chlorhexidine acetate and 0.1g disodium EDTA with 200ml water and mix them into the above colloidal solution, stir well, adjust the pH to 6.0, place it for 12 hours and subpackage to obtain metronidazole Azole glue finished product.
Embodiment 2
[0022] Dissolve 75g of metronidazole with 8000ml of water and put it in a container; mix 300g of glycerol, 200g of propylene glycol, 100g of polyoxyethylene polyoxypropylene copolymer and 300g of polyethylene oxide 8000, and put it in a homogenizer to homogenize Dissolve the material into a colloidal solution; in another container, dissolve 7g of chlorhexidine acetate and 1g of disodium EDTA with 2000ml of water and mix them into the above-mentioned colloidal solution, stir well, adjust the pH to 7.0, place it for 10 hours, and then pack it separately. Get metronidazole mucilage.
Embodiment 3
[0024] Dissolve 1g of metronidazole with 800ml of water and put it in a container; mix 50g of glycerol, 100g of polyoxyethylene polyoxypropylene copolymer and 1g of polyethylene oxide 6000, and stir until the material dissolves into a colloidal solution; In another container, 10 g of chlorhexidine hydrochloride and 0.5 g of disodium EDTA were dissolved in 200 ml of water and mixed into the above-mentioned colloidal solution, adjusted to a pH of 6.5, fully stirred to obtain a metronidazole glue.
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