Metronidazole mucilage and preparation method thereof

The technology of metronidazole glue and metronidazole is applied in the directions of pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc. Sensitivity and other problems, to achieve the effect of favorable treatment and rehabilitation protection, rapid onset time, comfortable subjective feeling
CN102895177BActive Publication Date: 2014-05-07上海瑞圣生物医学科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
上海瑞圣生物医学科技有限公司
Publication Date
2014-05-07

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Abstract

The invention discloses a metronidazole mucilage which is characterized by comprising the following components in parts by weight: 1000 parts of water, 1-10 parts of metronidazole, 10-300 parts of glycerol and / or propylene glycol, 0.1-10 parts of chlorhexidine, 1-100 parts of polyethylene oxide, 5-100 parts of polyoxyethylene polypropylene oxide copolymer and 0.05-0.5 parts of EDTA (Ethylene Diamine Tetraacetic Acid) disodium. The invention also discloses a preparation method of the metronidazole mucilage, comprising the steps of dissolving metronidazole by using water, adding other components, and fully and uniformly mixing to form a colloidal solution. The metronidazole mucilage disclosed by the invention has the due efficacy of metronidazole drugs and is capable of simulating cervix uteri, vagina mucus and moist local ecological environment of healthy women, suitable for the treatment and the rehabilitation protection of female reproductive tract infections, menopause vaginitis and reproductive tract infection after the uterus ovarian surgery and capable of overcoming the defect that the dispersion of traditional vaginal effervescent tablets, vaginal suppositories and lotions may be influenced due to insufficient environmental moisture.
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Description

technical field

[0001] The invention relates to a pharmaceutical preparation, in particular to a metronidazole mucilage; in addition, the invention also relates to a preparation method of the metronidazole mucilage. Background technique

[0002] Metronidazole is a commonly used drug to treat vaginitis and senile vaginitis in menopausal women and patients after uterine and ovarian surgery. Its dosage forms include vaginal effervescent tablets and vaginal suppositories. sense of flaws.

[0003] The basic principle of vaginal effervescent tablets is that the acid-base substances contained in the tablets undergo a neutralization reaction in the presence of moisture in the vaginal environment, and at the same time release carbon dioxide gas to form a drug-containing foam to disperse the drug. The vaginal suppository is in the process of melting from solid to liquid In addition to the temperature factor, moisture is also a necessary condition. For patients with insufficient vagin...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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