Application of Ruyizhenbao pill/tablet to treatment of vascular dementia

A technology of vascular dementia, treasure, applied in the field of medicine

Active Publication Date: 2014-06-25
GANSU CHEEZHENG TIBETAN MEDICINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the treatment of vascular dementia or related diseases with Ruyi Zhenbao pills / tablets

Method used

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  • Application of Ruyizhenbao pill/tablet to treatment of vascular dementia
  • Application of Ruyizhenbao pill/tablet to treatment of vascular dementia
  • Application of Ruyizhenbao pill/tablet to treatment of vascular dementia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] [Example 1] Making of VD Rat Model and Experimental Animal Grouping

[0071] 250 adult healthy male SD rats were first trained in the MG-3 Y-shaped maze, and the rats that were too slow in response or particularly sensitive to electrical stimulation were eliminated (31 rats were eliminated). 20 rats were randomly selected as the sham operation group, and the remaining 199 rats were used to make VD animal models by permanent ligation of bilateral common carotid arteries. Rats were fasted for 12 hours before operation, rats were weighed, intragastric administration of metoprolol (0.5mg / kg), half an hour later intraperitoneal injection of 1% pentobarbital sodium (4.5ml / kg) for anesthesia, preoperative orbital Bloodletting 3ml, the rat was fixed in a supine position, the skin was prepared, disinfected, a median incision was made in the neck, the pulsation of the common carotid artery could be seen after blunt separation of the sternohyoid and sternocleidomastoid muscles, an...

Embodiment 2

[0073] [Example 2] Behavioral experiment

[0074] 1 Effect of Ruyi Zhenbao Tablets on Learning and Memory of VD Rats

[0075] Rats in each group were tested with MG-3 Y-type maze to test their memory performance. The Y-maze consists of three identical arms, called arms I, II, and III. Electric grids with a diameter of 0.2 cm, a length of 14 cm, and a distance of 1 cm are laid on the bottom of the maze, which can be stimulated by electricity. A 15W signal light is installed on the top of each arm, and the light is used as a signal for electric shock to train rats to distinguish light stimulation and safe range. During the experiment, the light at the end of one arm was shining brightly. At this time, the grid at the bottom of the arm had no current passing through it, which was a safe area. The lights of the other two arms were not lit, and the power grid at the bottom was energized, which was an unsafe area. Safe and non-safe areas change randomly. Before the experiment, p...

Embodiment 3

[0090] [Example 3] Transmitter content determination experiment

[0091] 1 Effect of Ruyi Zhenbao Tablets on Monoamine Transmitters in the Brain of VD Rats

[0092] Preparation of brain homogenate samples:

[0093] After the experiment, the rats were decapitated directly, and the whole brains of the rats (cerebrum and diencephalon were retained) were peeled off on an ice platform, and weighed. Add perchloric acid at the ratio of 0.1 g brain (wet weight) to 1 ml 5% perchloric acid, put it into a glass homogenate tube, and homogenize under ice bath. The homogenate was collected in a 1.5ml centrifuge tube, centrifuged at -4°C for 20min at 12000r / min, and the supernatant was sampled for detection.

[0094] Chromatographic conditions:

[0095] Column: ZORBAX Eclipse Plus-C 18 , 150×4.6mm, 5μm.

[0096] The mobile phase is 0.1mol / L KH 2 PO 4 Buffer-methanol (volume ratio 9:1). The flow rate is 0.7ml / min, the injection volume is 20ul, the column temperature is 35°C, the exci...

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PUM

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Abstract

The invention provides application of a Ruyizhenbao pill / tablet to the treatment of vascular dementia, wherein the Tibetan drug is prepared by the following raw materials: nacre, agilawood, travertine, lapis micae aureus, carthamus tinctorius, crab, clove, pitted fructus terminaliae billericae, myristica fragrans, cardamun, phyllanthus emblica, amomum tsao-ko, ajowan, sandalwood, semen nigellae, lignum dalbergiae odoriferae, piper longum, pitted myrobalan, galangal, liquorice cream, cinnamon, olibanum, costustoot, semen cassiae, cornu bubali or cornu bubali concentrated powder, ambrette, lagotis brachystachya, radix inulae racemosae, muskone, calculus bovis factitius or in-vitro cultured calculus bovis.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a new application of Tibetan medicine Ruyi Zhenbao pills / tablets. Background technique [0002] Vascular dementias (vascular dementias, VD), also known as multi-infarct dementia, is the second leading cause of senile dementia, accounting for 10% to 50% of dementia. VD is a syndrome rather than a single disease. Different vascular pathological changes can cause VD symptoms, including large and small arterial lesions, diffuse ischemic white matter lesions, embolism of cardiac shedding emboli, and hemodynamic changes , bleeding, hematological factors and genetic diseases, etc. Pathophysiological mechanisms related to VD include focal ischemic damage, white matter lesions, other ischemia-related factors, and functional factors. In short, it is long-term hypertension, arteriosclerosis, recurrent lacunar infarction, or multiple infarctions caused by other reasons, leading to ventriculomegaly,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9064A61K9/20A61P25/28A61K35/56A61K35/413A61K35/32A61K33/06A61K35/612A61K35/618
Inventor 陈维武吴屾陈丽娟张国霞
Owner GANSU CHEEZHENG TIBETAN MEDICINE CO LTD
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