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Tumor chemotherapy early curative effect evaluation method based on ultrasonic backscatter radio-frequency analysis

An ultrasonic backscatter and radio frequency analysis technology, applied in the field of ultrasonic medicine, can solve the problems of inability to provide early chemotherapy effect and effective evaluation of tumors in time, and achieve the effect of improving the utilization rate of medical resources

Inactive Publication Date: 2013-04-17
SOUTH CHINA UNIV OF TECH
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Problems solved by technology

However, the existing inspection methods cannot provide timely and effective evaluation of the effect of chemotherapy in the early stage of tumors.

Method used

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  • Tumor chemotherapy early curative effect evaluation method based on ultrasonic backscatter radio-frequency analysis
  • Tumor chemotherapy early curative effect evaluation method based on ultrasonic backscatter radio-frequency analysis
  • Tumor chemotherapy early curative effect evaluation method based on ultrasonic backscatter radio-frequency analysis

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Embodiment 1

[0042] Taking breast cancer tissue as an example, the entire evaluation process of the early efficacy evaluation method for tumor chemotherapy based on ultrasonic backscatter radio frequency analysis is described in detail. The entire process is as follows: figure 1 shown.

[0043] 1. Obtain the ultrasound echo radio frequency RF signal of the tumor area before and after chemotherapy

[0044] A 128-element broadband linear array ultrasound probe (frequency range 5-14MHz) is used to scan the tumor area before and after chemotherapy respectively. The propagation of ultrasound is affected by the microstructure of the tumor, and the echo is received by the same linear array probe, which is amplified by radio frequency and time-gained. Compensation, and then through A / D conversion, delay synthesis, and then obtain the ultrasonic echo radio frequency RF signal.

[0045] 2. Demodulate to get B-type map

[0046] Such as image 3 As shown, the ultrasonic echo RF signal is logarithmi...

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Abstract

The invention discloses a tumor chemotherapy early curative effect evaluation method based on ultrasonic backscatter radio-frequency analysis, comprising the following steps: (1) scanning a tumor area to be detected by a broad-band ultrasonic linear probe, and using the same probe to obtain echo radio-frequency RF signals before and after chemotherapy respectively; (2) demodulating and obtaining a B-type diagram; (3) selecting an interesting area ROI of tumors in the B-type diagram, and intercepting backscatter radio-frequency RF signals; (4) calculating the power amplitude spectrum of the ROI; (5) calculating centroid frequency; (6) obtaining plane reflection signal as reference signal at a focal point, and calculating the centroid frequency; and (7) calculating the score of curative effect according to the centroid frequency of the reference signal before and after chemotherapy obtained from the above steps, and evaluating the early curative effect of tumor. The method provides a concept of evaluating the chemotherapy effect of tumor according to the change of tumor microstructure in the early period of chemotherapy, and provides objective basis for evaluating the curative effect of tumor chemotherapy.

Description

technical field [0001] The invention belongs to the technical field of ultrasonic medicine, and in particular relates to an early curative effect evaluation method of tumor chemotherapy based on ultrasonic backscattered radio frequency analysis. Background technique [0002] The incidence of tumors is very high now, and chemotherapy is an important means of treating tumors. In clinical medicine, the main means of evaluating the effect of chemotherapy is: general patients undergo imaging examinations such as CT, ultrasound or MRI after three courses of chemotherapy. Measure the long and short diameters of the tumor, compare them with the images before chemotherapy, compare the changes in the long and short diameters, and judge the changes in tumor size to determine the efficacy of chemotherapy. However, imaging examinations such as CT, MR, and ultrasound are all macroscopic morphological examinations that provide morphological information. Therefore, this method of observing ...

Claims

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Application Information

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IPC IPC(8): A61B8/08
Inventor 林春漪周建华黄庆华姚若河
Owner SOUTH CHINA UNIV OF TECH
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