Application of humulus lupulus effective parts applied to preparation of medicine for preventing and improving depression and clinical symptoms

A technology of effective parts and clinical symptoms, applied in the field of natural plant extraction and application, can solve the problems of prevention and improvement of depression that have not been reported yet

Inactive Publication Date: 2013-06-19
BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In recent years, reports on the pharmacological effects of hop extracts or compounds contained therein have mostly focused on antibacterial, antitumor, antioxidative, sedative, and estrogen-like effects. Clinical applications are mainly in tuberculosis, leprosy, and endocrine disorders. However, the effect of active parts of hops with alpha acid, beta acid and flavonoids on the prevention and improvement of depression and its clinical symptoms has not been reported yet.

Method used

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  • Application of humulus lupulus effective parts applied to preparation of medicine for preventing and improving depression and clinical symptoms
  • Application of humulus lupulus effective parts applied to preparation of medicine for preventing and improving depression and clinical symptoms
  • Application of humulus lupulus effective parts applied to preparation of medicine for preventing and improving depression and clinical symptoms

Examples

Experimental program
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Effect test

Embodiment 1

[0023] The preparation of embodiment 1 effective fraction of hops

[0024] Grind the dried hops, add 6 times of 50% ethanol to reflux and extract 4 times, the time of each extraction is 4, 3, 2, 1 hour in turn, combine the extracts, filter, concentrate under reduced pressure until there is no alcohol smell, add 95% Add ethanol while stirring until the ethanol concentration is 50%, let it stand overnight, take the supernatant, concentrate under reduced pressure until there is no ethanol smell, put it on the D101 macroporous resin column for adsorption, wash with 20% and 95% ethanol respectively After removing, collecting 95% ethanol eluate, recovering the organic solvent under reduced pressure, and drying under reduced pressure, the effective fraction of hops is obtained.

Embodiment 2

[0025] The preparation of embodiment 2 effective parts of hops

[0026] Grind the dried hops, add 10 times of 80% ethanol to reflux and extract for 3 times, the time of each extraction is 4, 3, 2 hours in turn, combine the extracts, filter, concentrate under reduced pressure until there is no alcohol smell, add 95% ethanol, Stir while adding until the ethanol concentration is 70%, let it stand overnight, take the supernatant, concentrate under reduced pressure until there is no ethanol smell, put it on the AB-8 type macroporous resin chromatographic column for adsorption, wash with 10% and 95% ethanol respectively After removing, collecting 95% ethanol eluate, recovering the organic solvent under reduced pressure, and spray drying to obtain the effective fraction of hops.

Embodiment 3

[0027] The preparation of embodiment 3 effective parts of hops

[0028] Grind the dried hops, add 12 times of 95% methanol to reflux and extract 3 times, each extraction time is 4, 3, 2 hours in turn, combine the extracts, filter, concentrate under reduced pressure until no alcohol smell, add 95% ethanol, Stir while adding until the ethanol concentration is 80%, let it stand overnight, take the supernatant, concentrate under reduced pressure until there is no ethanol smell, put it on HP-20 type macroporous resin chromatographic column for adsorption, wash with 30% and 95% methanol respectively The 95% methanol eluate was collected, concentrated under reduced pressure to recover the organic solvent, and freeze-dried to obtain the effective fraction of hops.

[0029] The effective fractions of hops obtained in Examples 1 to 3 are used in the following experiments to verify their effects.

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Abstract

The invention relates to a method of preparation of humulus lupulus (humulus lupulus L) effective parts, in particular to an application of the humulus lupulus effective parts applied to preparation of pharmaceutic preparation for preventing and improving depression and various clinical symptoms caused by the depression. The active constituents of the humulus lupulus effective parts are mainly composed of alpha acid, beta acid and flavone. According to animal experiments, the humulus lupulus effective parts can reduce autonomic movement intensity of a mouse, increase turning number of the fore limbs of the mouse stirring a reel to rotate, shorten immovability time of the mouse, and reduce the temperature dropping of the mouse caused by antagonism reserpine, and therefore the humulus lupulus effective parts can be used for preventing and improving the depression and the various clinical symptoms caused by the depression.

Description

technical field [0001] The invention relates to the extraction and application of natural plants, in particular to the application of the effective part of hops (Humunus Lupulus L) for preparing antidepressant and its clinical symptoms. Background technique [0002] Depression is a common mental illness, mainly manifested as low mood, loss of interest, pessimism, slow thinking, lack of initiative, self-blame, poor diet and sleep, etc. In severe cases, suicidal thoughts and behaviors may appear. The incidence of depression is very high, almost 1 in 7 adults suffer from depression. Depression has become the second most important disease causing serious burden to human beings. In my country, the incidence rate of depression is about 3% to 5%. White-collar workers living in big cities have become a group with high incidence of this disease under the environment of high pressure and high competition. Therefore, from the perspective of physical health and living habits, the deve...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/60A61P25/24
Inventor 续洁琨张维库
Owner BEIJING UNIV OF CHINESE MEDICINE
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