Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

dilated vaginal suppositories

A vaginal suppository and swelling value technology, applied in the directions of suppository delivery, absorbent pads, pharmaceutical formulations, etc., can solve the problems of low curative effect, strong discomfort, contaminated clothing, etc., and achieve the effect of overcoming poor compliance and strong discomfort

Active Publication Date: 2016-01-13
哈尔滨田美药业股份有限公司
View PDF10 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The above-mentioned vaginal suppositories are all committed to solving the problem of more accurately providing medicine to the disease site and contaminating clothes with medicinal liquid, but generally speaking, there are still the following deficiencies: 1. The active ingredient is not in sufficient contact with the vaginal epithelium and mucosal wall, let alone selectivity Contact; 2, the vagina is an open organ, and the medicine is easily slipped off or flows out of the medicine liquid after melting or dissolving in the vagina, causing contamination of the clothes, and the prior art solutions all adopt the method of blocking, but the effect is not satisfactory, The problem of not being easy to clean has not been completely solved
3. Poor user compliance and strong discomfort
4. No good quality control methods
5. The weight difference is not easy to control, and the content uniformity cannot meet the requirements of the Pharmacopoeia
6. The curative effect of some active ingredients is lower than that of systemic administration
7. The sliver swells irregularly, and the contradiction that the sliver swells rapidly when it encounters water and cannot absorb too much liquid medicine cannot be solved

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • dilated vaginal suppositories
  • dilated vaginal suppositories
  • dilated vaginal suppositories

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Such as figure 1 As shown in the expanded vaginal suppository 11 of the present invention, the drug-containing matrix layer 12 is in a semi-enclosed state and surrounds the sterile expanded tampon 13 and the permeable medicated gauze 14 that wraps it. combine figure 2 As shown, there is an axial keel 14 on the surface of the sterile expanded tampon 13, and a backguy 15 at the tail. After the expansion vaginal suppository 11 expands in the vagina 16, the pull-out end 17 expands earlier, and combines image 3 Shown is the state of the expanded vaginal suppository 11 after expansion.

Embodiment 2

[0047] Such as Figure 4 As shown, it is the state before the expansion vaginal suppository 21 of the present invention is put into the vagina 22 before it expands. When encountering the liquid in the vagina 22, it can rapidly expand as Figure 5 As shown in the expanded state, it can be seen that the expansion range of the pull-out end 23 of the inflatable vaginal suppository 21 is greater than that of the entry end, and several annular protrusions 24 are close to the vaginal wall, which is beneficial to the absorption of drugs and avoids drug absorption. The liquid flows out, and the multiple ring-shaped protrusions are adsorbed respectively, instead of passively intercepting and easily slipping or flowing out of the liquid medicine after melting or dissolving in the vagina, the medicine is divided, adsorbed and intercepted by different expansion parts of the first expansion carrier 31, clean thorough.

Embodiment 3

[0049] Such as Image 6 As shown in the expansive vaginal suppository 31, the protective layer is three non-woven fabrics 32 of different volumes, which are respectively placed on the pull-out end and the entry end of the expansion carrier before expansion. After expansion, as shown in FIG. Figure 7 As shown, the non-woven fabric 32 can limit the expansion range of the expansion carrier 33 .

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to an expandable vaginal suppository. The expandable vaginal suppository also includes a first expansion carrier, and a suppository layer composed of an active ingredient and a matrix covers at least one end of the first expansion carrier. The vaginal suppository has a pH value of 3.0- The expansion value of the first expansion carrier is 1-30 when saturated with water absorption. The expansion vaginal suppository of the present invention can be fully and selectively fully contacted with the vaginal epithelium and the mucous membrane wall, and the bioavailability of the active drug is increased by 20-40% on average; the different positions of the suppository body can expand in different ranges to make the tampon vaginal suppository The problem of not being easy to clean has been completely solved, and problems such as poor user compliance and strong discomfort have been overcome.

Description

technical field [0001] The invention relates to an expanding vaginal suppository for delivering medicinal ingredients, in particular to a vaginal suppository which can be expanded according to a predetermined expansion value. Background technique [0002] Vaginal suppository refers to a solid preparation made of a drug and a suitable base for vaginal administration. Vaginal suppositories are generally duckbill-shaped, spherical or oval, etc., and can be made into ordinary suppositories or sustained-release suppositories. Vaginal suppositories are commonly prepared with water-soluble or water-miscible bases. The drug and matrix in the suppository should be mixed evenly, and the shape of the suppository should be complete and smooth; it should be non-irritating after being inserted into the cavity, and should be able to melt, soften or dissolve, and mix with the secretion to gradually release the drug to produce local or systemic effects ; There should be appropriate hardnes...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/02
CPCA61F13/2074A61F13/202A61F13/2028A61K9/0034A61K9/02
Inventor 邱学良邱明世
Owner 哈尔滨田美药业股份有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com