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Production technology for extracting oxytetracycline dihyclorate by utilizing hydrochloric acid and oxalic acid

A technology of oxytetracycline base and production process, which is applied in the field of production process of extracting oxytetracycline base, can solve the problems of rising production cost of oxytetracycline base, rising price of oxalic acid, lower competitiveness, etc., and achieve reduction of raw material procurement expenses , Improving market competitiveness and reducing production costs

Active Publication Date: 2015-06-03
INNER MONGOLIA KAISHENG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the production process of oxytetracycline base, due to the use of a large amount of oxalic acid, the price of oxalic acid continues to rise and remain high, resulting in an increase in the production cost of oxytetracycline base (raw material drug), which makes enterprises compete in the production industry of oxytetracycline base Power decreases year by year

Method used

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  • Production technology for extracting oxytetracycline dihyclorate by utilizing hydrochloric acid and oxalic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1: a kind of production technology that hydrochloric acid and oxalic acid are used to extract oxytetracycline alkali, it comprises the following steps: (1) fermentation; (2) acidification filtration; (3) decolorization crystallization; (4) drying, mixing powder packaging Prepare the finished product of oxytetracycline base;

[0022] Wherein, step (1) fermentation comprises:

[0023] a. Preparation of slant spores: conditions for culturing spores: culture slant spores at 36°C, humidity 55%, culture time 96h;

[0024] b. Primary seed tank cultivation: the cultivation temperature is 30.5°C, the equipment is sealed, and the air is stirred. After about 26 hours of fermentation, it is transferred into the secondary seed tank;

[0025] c. Secondary seed tank cultivation: the cultivation temperature is 30.5°C, mechanical stirring, sterile air, fermentation for 20 hours, and transfer to the third-stage fermenter;

[0026] d. Three-stage fermenter fermentation: the i...

Embodiment 2

[0035] Embodiment 2: a kind of production technology that hydrochloric acid and oxalic acid are used to extract oxytetracycline alkali, it comprises the following steps: (1) fermentation; (2) acidification filtration; (3) decolorization crystallization; (4) drying, mixing powder packaging Prepare the finished product of oxytetracycline base;

[0036] Wherein step (1) fermentation comprises:

[0037] a. Preparation of slant spores: conditions for culturing spores: culture slant spores at 37°C, humidity 60%, culture time 120h;

[0038] b. Primary seed tank cultivation: the cultivation temperature is 31.5°C, the equipment is sealed, and the air is stirred. After about 28 hours of fermentation, it is transferred to the secondary seed tank;

[0039] c. Secondary seed tank cultivation: the cultivation temperature is 31.5°C, mechanical stirring, sterile air, fermentation for 28 hours, and transfer to the third-stage fermenter;

[0040] d. Fermentation in a three-stage fermenter: th...

Embodiment 3

[0049] Embodiment 3: a kind of production technology that hydrochloric acid and oxalic acid are used to extract oxytetracycline alkali, it comprises the following steps: (1) fermentation; (2) acidification filtration; (3) decolorization crystallization; (4) drying, mixing powder packaging Prepare the finished product of oxytetracycline base;

[0050] Wherein, step (1) fermentation comprises:

[0051] a. Preparation of slant spores: culture conditions for spores: culture slant spores at 36.5°C, humidity 58%, culture time 110h;

[0052]b. Primary seed tank cultivation: the cultivation temperature is 31°C, the equipment is sealed, and the air is stirred. After about 27 hours of fermentation, it is transferred to the secondary seed tank;

[0053] c. Secondary seed tank cultivation: the cultivation temperature is 31°C, mechanical stirring, sterile air, fermentation for 24 hours, and transfer to the third-stage fermenter;

[0054] d. Three-stage fermenter fermentation: the inocula...

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Abstract

The invention discloses a production technology for extracting oxytetracycline dihyclorate by utilizing hydrochloric acid and oxalic acid. The production technology comprises the following steps of: (1) fermenting; (2) acidizing and filtering; (3) decoloring and crystallizing; (4) drying, mixing and packaging to prepare an oxytetracycline dihyclorate product, wherein the step (2) is as follows: acidizing a fermentation liquor, namely adding oxalate to the fermentation liquor prepared in the step (1) to adjust the PH value of the fermentation liquor to 2.10-2.20; and then adding hydrochloric acid to the fermentation liquor, and adjusting the PH value of the fermentation liquor to 1.80-2.0. The production technology has the advantages that adjustment is carried out by an extraction and acidification process; the production cost of a company is greatly reduced by the hydrochloric acid and the oxalate; the purchasing cost of raw materials is reduced; the production cost can be saved by **-** each month; the production cost is reduced; and the market competitiveness of an enterprise is improved.

Description

technical field [0001] The invention relates to a production process for extracting oxytetracycline base, in particular to a production process for extracting oxytetracycline base by combining hydrochloric acid and oxalic acid. Background technique [0002] Oxytetracycline is a broad-spectrum antibiotic prepared by soil Streptomyces. Some protozoa (such as: coccidia) have inhibitory effect. Now it is mainly used in livestock and poultry medicine and feed additive. [0003] In the production process of oxytetracycline base, due to the use of a large amount of oxalic acid, the price of oxalic acid continues to rise and remain high, resulting in an increase in the production cost of oxytetracycline base (raw material drug), which makes enterprises compete in the production industry of oxytetracycline base Power is decreasing year by year. Utility model content [0004] The object of the present invention is to provide a kind of greatly reducing the production cost of oxyte...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12P15/00C07C237/26C07C231/24
Inventor 李建昭
Owner INNER MONGOLIA KAISHENG BIOTECH