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Application of centipede pseudo-ginseng extract product in preparation of medicine against intestinal adhesion and medicine thereof

A technology of extract and intestinal adhesion, which is applied in the field of medicinal use of centipede panax notoginseng extract and its pharmaceutical composition to achieve the effect of preventing intestinal adhesion

Inactive Publication Date: 2013-11-06
WUHAN DAO YI TANG PHARMA RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the effect of centipede notogins

Method used

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  • Application of centipede pseudo-ginseng extract product in preparation of medicine against intestinal adhesion and medicine thereof
  • Application of centipede pseudo-ginseng extract product in preparation of medicine against intestinal adhesion and medicine thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1: Preventive effect of Centipede Panax notoginseng extract on intestinal adhesion in rats

[0016] 1.1 Experimental materials

[0017] 1.1.1 Animals: SD rats, half male and half female, weighing 180-200 g, provided by the Experimental Animal Center of Huazhong University of Science and Technology, license number: SCXK (E) 2010-0009.

[0018] 1.1.2 Drugs:

[0019] The medicine of the present invention, centipede notoginseng extract (total saponin content about 60%) is prepared by conventional water decoction method, taking centipede notoginseng medicinal material, adding 2 to 8 times the mass of water to decoct 3 to 5 times, each time for 1 to 4 hours , filter, combine the filtrates, concentrate the filtrate to a liquid with a relative density of 1.04 to 1.1 at 60°C, let it cool, add ethanol to make the alcohol content 40 to 80%, stir well, let it stand for 12 hours, filter, and recover ethanol. Volatile until no alcohol smell, get extract, add water to dissol...

Embodiment 2

[0040] Example 2: 30 Cases of Postoperative Intestinal Adhesion Prevented by Centipede Panax notoginseng Extract

[0041] 2.1 Experimental materials

[0042] 2.1.1 Medicine: the medicine of the present invention, centipede notoginseng extract, prepared by conventional water decoction method, the total saponin content is about 60%, the centipede notoginseng extract powder and micropowder silica gel (accounting for about 0.4% of the total amount) are mixed evenly, and the 60-mesh sieve, pack into capsules, and obtain the centipede notoginseng extract capsules.

[0043] 2.1.2 Objects: 60 cases of various abdominal operations were selected and randomly divided into the treatment group and the control group, 30 cases each. There was no significant difference in the general conditions of the two groups, which were comparable.

[0044] 2.2 Treatment methods

[0045] 2.2.1 Dosing regimen

[0046] 12 hours after the operation, the administration group took orally the capsules of cen...

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Abstract

The application relates to an application of a centipede pseudo-ginseng extract product in the preparation of a medicine against intestinal adhesion and a medicine thereof. The application discloses an application of a centipede pseudo-ginseng extract product in the preparation of a medicine for preventing or treating intestinal adhesion and a pharmaceutical composition thereof. The centipede pseudo-ginseng extract product contains centipede Panax Notoginseng Saponins. The centipede pseudo-ginseng extract product is prepared by a water decoction method. It proves through pharmacological testing and clinical tests that the centipede pseudo-ginseng extract product has a good effect of preventing intestinal adhesion and has high-efficiency and low-toxicity advantages.

Description

technical field [0001] The present invention relates to the medical use of centipede notoginseng extract and its pharmaceutical composition. Background technique [0002] Intestinal adhesion is a common complication after abdominal and pelvic surgery. According to reports, the proportion of intestinal adhesion in varying degrees after abdominal surgery is as high as 80-90%. Studies have shown that intestinal adhesion is related to the inflammatory exudation of the abdominal cavity and the weakening of intestinal motility. The inflammatory reaction leads to inflammatory exudation and fibrin deposition, and then the deposits are transformed into fibrinous tissue to form adhesions. Adhesion is a repair response of the body's immune system to damaged and ischemic tissue, but excessive adhesion can lead to serious complications - intestinal obstruction. Therefore, it is of great clinical significance to develop new drugs for the prevention and treatment of intestinal adhesion wi...

Claims

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Application Information

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IPC IPC(8): A61K36/71A61P1/00A61P29/00A61P37/02
Inventor 廖一帆江哲遒邴飞虹
Owner WUHAN DAO YI TANG PHARMA RES INST
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