A local anesthetic composition comprising bupivacaine and application thereof

A technology of local anesthesia and bupivacaine, applied in the field of medicine, can solve problems such as long recovery time, hemodynamic instability, complete motor nerve block, etc., and achieve the effect of improving safety and accuracy

Inactive Publication Date: 2016-03-16
QINGDAO CENT HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when the conventional dose (15mg) of bupivacaine is used for spinal anesthesia, although it can produce satisfactory labor pain effect, it also has the disadvantages of hemodynamic instability, complete motor nerve block and long recovery time.

Method used

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  • A local anesthetic composition comprising bupivacaine and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The freeze-dried powder injection preparation of embodiment 1 anesthesia composition

[0020] Bupivacaine: 3.0mg,

[0021] Sufentanil: 1 mu g;

[0022] Corydalin: 30 mu g;

[0023] Indomethacin: 15 mu g;

[0024] Ropivacaine: 0.1mg

[0025] Dissolve the corresponding anesthetic composition components and 100 mg glucose in water for injection according to the prescription amount, add activated carbon for adsorption, decarbonize and filter, 0.22 mu M microporous membrane filtration, the obtained filtrate is then divided into sterile vials according to the aforementioned dosage specifications under aseptic conditions, and freeze-dried in a vacuum to obtain a freeze-dried powder; then seal the ampoule with a plastic aluminum cap vial , labeling, and ethylene oxide sterilization to obtain the freeze-dried powder injection.

[0026] The vacuum freeze-drying method is as follows: 1. Quickly freeze and pre-freeze at ultra-low temperature of -40°C~-60°C for 2 hours to ...

Embodiment 2

[0027] The freeze-dried powder injection preparation of embodiment 2 anesthesia composition

[0028] Bupivacaine: 3.0mg,

[0029] Sufentanil: 3 mu g;

[0030] Corydalin: 20 mu g;

[0031] Indomethacin: 20 mu g;

[0032] Ropivacaine: 0.3mg

[0033] Dissolve the corresponding anesthetic composition components and 100 mg glucose in water for injection according to the prescription amount, add activated carbon for adsorption, decarbonize and filter, 0.22 mu M microporous membrane filtration, the obtained filtrate is then divided into sterile vials according to the aforementioned dosage specifications under aseptic conditions, and freeze-dried in a vacuum to obtain a freeze-dried powder; then seal the ampoule with a plastic aluminum cap vial , labeled to obtain the freeze-dried powder injection.

[0034] The vacuum freeze-drying method is as follows: 1. Quickly freeze and pre-freeze at ultra-low temperature of -40°C~-60°C for 2 hours to form fine crystals; 2. Then raise t...

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Abstract

The invention relates to the field of medicine, in particular to a medicine composition with anesthesia effect in operation. It consists of 1.0-3.0mg of bupivacaine, 1-5 mu g sufentanil, 15-30 mu g of tetrahydropalmatine, 15-30 mu g of indomethacin and 0.1-0.5 mg of ropivacaine. The anesthetic composition preferably consists of 3.0 mg of bupivacaine, 3 mu g sufentanil, 20 mu g of tetrahydropalmatine, 20 mu g of indomethacin and 0.3 mg of ropivacaine.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a medicine composition with anesthesia effect in operation. Background technique [0002] With the improvement of living standards, my country has gradually entered an aging society, and the proportion of elderly patients among surgical patients is gradually increasing. In China, most lower abdomen and lower extremity operations are performed under spinal anesthesia. The use of spinal anesthesia in elderly patients can improve the success rate of anesthesia and reduce the incidence of block insufficiency. [0003] However, due to the decline of organ function, the stress ability of elderly patients is poor, and some of them are in a state of tension and anxiety. They often cannot bear the strong stimulation brought by surgical trauma, and the regulation function of their autonomic nervous system declines. Sudden deterioration or even accidents. Therefore, under spinal anesthesia and epi...

Claims

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): A61K31/4535A61P23/02A61K31/445A61K31/4375A61K31/405
Inventor王寿世冯梅刁玉晶
OwnerQINGDAO CENT HOSPITAL